On the relation between entanglement and subsystem Hamiltonians

We show that a proportionality between the entanglement Hamiltonian and the Hamiltonian of a subsystem exists near the limit of maximal entanglement under certain conditions. Away from that limit, solvable models show that the coupling range differs in both quantities and allow to investigate the effect.Comment: 7 pages, 2 figures version2: minor changes, typos correcte

Phase-sensitive quantum effects in Andreev conductance of the SNS system of metals with macroscopic phase breaking length

The dissipative component of electron transport through the doubly connected SNS Andreev interferometer indium (S)-aluminium (N)-indium (S) has been studied. Within helium temperature range, the conductance of the individual sections of the interferometer exhibits phase-sensitive oscillations of quantum-interference nature. In the non-domain (normal) state of indium narrowing adjacent to NS interface, the nonresonance oscillations have been observed, with the period inversely proportional to the area of the interferometer orifice. In the domain intermediate state of the narrowing, the magneto-temperature resistive oscillations appeared, with the period determined by the coherence length in the magnetic field equal to the critical one. The oscillating component of resonance form has been observed in the conductance of the macroscopic N-aluminium part of the system. The phase of the oscillations appears to be shifted by $\pi$ compared to that of nonresonance oscillations. We offer an explanation in terms of the contribution into Josephson current from the coherent quasiparticles with energies of order of the Thouless energy. The behavior of dissipative transport with temperature has been studied in a clean normal metal in the vicinity of a single point NS contact.Comment: 9 pages, 7 figures, to be published in Low Temp. Phys., v. 29, No. 12, 200

Magnetotransport in a two-dimensional electron system in dc electric fields

We report on nonequilibrium transport measurements in a high-mobility two-dimensional electron system subject to weak magnetic field and dc excitation. Detailed study of dc-induced magneto-oscillations, first observed by Yang {\em et al}., reveals a resonant condition that is qualitatively different from that reported earlier. In addition, we observe dramatic reduction of resistance induced by a weak dc field in the regime of separated Landau levels. These results demonstrate similarity of transport phenomena in dc-driven and microwave-driven systems and have important implications for ongoing experimental search for predicted quenching of microwave-induced zero-resistance states by a dc current.Comment: Revised version, to appear in Phys. Rev.

Non-linear magnetotransport in microwave-illuminated two-dimensional electron systems

We study magnetoresistivity oscillations in a high-mobility two-dimensional electron system subject to both microwave and dc electric fields. First, we observe that the oscillation amplitude is a periodic function of the inverse magnetic field and is strongly suppressed at microwave frequencies near half-integers of the cyclotron frequency. Second, we obtain a complete set of conditions for the differential resistivity extrema and saddle points. These findings indicate the importance of scattering without microwave absorption and a special role played by microwave-induced scattering events antiparallel to the electric field.Comment: 4 pages, 4 figure

Shifts of the nuclear resonance in the vortex lattice in YBa2_2Cu3_3O7_7

The NMR and NQR spectra of $^{63}$Cu in the CuO$_2$ plane of YBa$_2$Cu$_3$O$_7$ in the superconducting state are discussed in terms of the phenomenological theory of Ginzburg-Landau type extended to lower temperatures. We show that the observed spectra, Kumagai {\em et al.}, PRB {\bf 63}, 144502 (2001), can be explained by a standard theory of the Bernoulli potential with the charge transfer between CuO$_2$ planes and CuO chains assumed.Comment: 11 pages 7 figure

Development and Bias Assessment of a Method for Targeted Metagenomic Sequencing of Marine Cyanobacteria

Prochlorococcus and Synechococcus are the most abundant photosynthetic organisms in oligotrophic waters and responsible for a significant percentage of the earth's primary production. Here we developed a method for metagenomic sequencing of sorted Prochlorococcus and Synechococcus populations using a transposon-based library preparation technique. First, we observed that the cell lysis technique and associated amount of input DNA had an important role in determining the DNA library quality. Second, we found that our transposon-based method provided a more even coverage distribution and matched more sequences of a reference genome than multiple displacement amplification, a commonly used method for metagenomic sequencing. We then demonstrated the method on Prochlorococcus and Synechococcus field populations from the Sargasso Sea and California Current isolated by flow cytometric sorting and found clear environmentally related differences in ecotype distributions and gene abundances. In addition, we saw a significant correspondence between metagenomic libraries sequenced with our technique and regular sequencing of bulk DNA. Our results show that this targeted method is a viable replacement for regular metagenomic approaches and will be useful for identifying the biogeography and genome content of specific marine cyanobacterial populations

Density Matrices for a Chain of Oscillators

We consider chains with an optical phonon spectrum and study the reduced density matrices which occur in density-matrix renormalization group (DMRG) calculations. Both for one site and for half of the chain, these are found to be exponentials of bosonic operators. Their spectra, which are correspondingly exponential, are determined and discussed. The results for large systems are obtained from the relation to a two-dimensional Gaussian model.Comment: 15 pages,8 figure

Blood lipid profiles and peripheral blood mononuclear cell cholesterol metabolism gene expression in patients with and without methotrexate treatment

<p>Abstract</p> <p>Background</p> <p>Methotrexate (MTX) is the most commonly prescribed disease-modifying antirheumatic drug (DMARD) in rheumatoid arthritis. ATP-binding cassette transporter-A1 (ABCA1) and 27-Hydroxylase (HY27) are known antiatherogenic proteins that promote cellular cholesterol efflux. In THP-1 macrophages, MTX can promote the reversal of cholesterol transport, limit foam cell formation and also reverse COX-2 inhibitor-mediated downregulation of ABCA1. Despite its antiatherogenic potential <it>in vitro</it>, the impact of clinical use of low-dose MTX on cholesterol metabolism in humans is unknown. Objective of the study was to examine whether clinical MTX use is associated with altered blood lipids and/or <it>ABCA1/HY27 </it>expressions.</p> <p>Methods</p> <p>In all, 100 rheumatoid arthritis subjects were recruited from a medical center in central Taiwan. Plasma lipid profiles and peripheral blood mononuclear cell <it>HY27 </it>and <it>ABCA1 </it>expressions were compared between subjects taking MTX (MTX+) and other disease-modifying antirheumatic drugs (DMARDs) (MTX-). Dietary intake was assessed by a registered dietician.</p> <p>Results</p> <p>Though no difference observed in the blood lipids between MTX+ and MTX- subjects, the expressions of <it>ABCA1 </it>and <it>HY27 </it>were significantly elevated in MTX+ subjects (n = 67) compared to MTX- subjects (n = 32, p < 0.05). ABCA expression correlated with MTX doses (r = 0.205, p = 0.042), and MTX+ subjects are more likely to have increased <it>HY27 </it>compared to MTX- subjects (OR = 2.5, p = 0.038). Prevalence of dyslipidemia and overweight, and dietary fat/cholesterol intake were lower than that of the age-matched population. Although no differences were observed in the blood lipids, the potential impacts of MTX on cholesterol metabolism should not be overlooked and the atheroprotective effects from MTX induced <it>HY27 </it>and <it>ABCA1 </it>expressions may still be present in those persons with pre-existing dyslipidemia.</p> <p>Conclusions</p> <p>We demonstrated novel findings on the increased gene expressions of atheroprotective protein <it>HY27 </it>and <it>ABCA1 </it>in human peripheral blood mononuclear cells (PBMCs) with clinical use of low-dose MTX. Whether MTX induced <it>HY27 </it>and <it>ABCA1 </it>expressions can protect against cardiovascular disease in patients with chronic inflammation through the facilitation of cholesterol export remains to be established. Further studies on the impacts of low-dose MTX on hypercholesterolemic patients are underway.</p

Calibration and performance of a secondary emission chamber as a beam intensity monitor

We report on a study of the behavior of a secondary emission chamber (SEC). We show the dependence of the SEC signal on the charge and velocity of the primary beam for beams of protons, and heavy ions including Helium, Neon, Chlorine and Iron. We fill the SEC with a selection of different gases including Hydrogen, Helium, Nitrogen, Argon, and air, studying the SEC response when it is acting as an ion chamber. We also investigate the behavior of the SEC at intermediate pressures between 10{sup -8} torr and atmospheric pressure. The SEC uses thin conducting foils as the source and collector of electrons in a vacuum chamber. When charged particles traverse the vacuum chamber, they pass through a series of thin conducting foils, alternating anode and cathode. Ionization produced in the cathode foils travels across the intervening gap due to an applied high voltage and is collected on the anode foils. Electron production is very inefficient because most of the ionization in the foils remains trapped within the foil due to the short range of most delta-rays and the work function of the foil. It is this inefficiency that allows the SEC to operate at high dose rates and short pulse duration where the standard ion chambers cannot function reliably. The SEC was placed in the NSRL ion beam to receive a variety of heavy ion beams under different beam conditions. We used these ion beams to study the response of the SEC to different species of heavy ion, comparing with proton beams. We studied the response to beam of different energies, and as a function of different counting rate. We compared the behaviour of the SEC when operating under positive and negative high voltage. The SEC can operate as an ion chamber if it is filled with gas. We measured the response of the SEC when filled with a variety of gases, from Hydrogen to Helium, Nitrogen, Argon and air. The performance of the SEC as an ion chamber is compared with the standard NSRL ion chamber, QC3. By evacuating the SEC and filling it with Nitrogen through an adjustable leak valve, we were able to measure the response of the SEC to beam as a function of gas pressure. Many interesting features of the SEC were revealed in these tests