Cummulative incidence of peripheral arterial occlusive disease in patients with schizophrenia and comparison patients.

<p>Cummulative incidence of peripheral arterial occlusive disease in patients with schizophrenia and comparison patients.</p

Construction and optimization of PPRE reporter constructs.

<p>(A) The schematic diagram of PPRE reporter constructs. Two PPRE oligonucleotides were annealed and ligated to form various tandem repeats of PPRE. The resulting products were analyzed by 8% polyacrylamide gels (left panel). Eight reporter constructs containing various numbers of PPREs were shown on the right. (B) Effect of rosiglitazone on the inducibility of PPRE reporter constructs. HepG2 cells were transiently transfected with PPRE constructs and pcDNA3.1/lacZ DNA, and treated without or with 0.5 µM rosiglitazone. Luciferase and β-galactosidase activities were determined 24 hours later. Luciferase activities are expressed as induction fold, which is presented as comparison with RLU related to untreated cells. β-Galactosidase activities are expressed as OD420. Values are mean ± standard error of three independent assays. **<i>p</i><0.01, ***<i>p</i><0.001, compared with untreated cells. (C) <i>In vitro</i> imaging. HepG2 cells were transiently transfected with PPRE constructs containing 5 tandem repeats of PPRE and treated without or with 0.5 µM rosiglitazone. Luciferase activity was imaged at 24 h by IVIS system. The color overlay on the image represents the photon/sec emitted from the cells, as indicated by the color scale. Quantification of photon emission from the cells was shown at the bottom. Values are mean ± standard error of three independent assays. ***<i>p</i><0.001, compared with mock. Photos are representative images.</p

The adjusted hazard ratio of tuberculosis in different risk factors.

<p>The adjusted hazard ratio of tuberculosis in different risk factors.</p

Incidence rate and adjusted hazard ratio of pulmonary embolism between ACOS and non-ACOS cohorts stratified by sex, age, comorbidity (no/yes), and drug used (no/yes).

<p>Incidence rate and adjusted hazard ratio of pulmonary embolism between ACOS and non-ACOS cohorts stratified by sex, age, comorbidity (no/yes), and drug used (no/yes).</p

Process of selecting subjects for study cohorts.

<p>Process of selecting subjects for study cohorts.</p

A bar graph representing the SUV_max from 4D-PET and 4D-PET_ICT for each patient.

<p>The percentage difference between 4D-PET and 4D-PET_ICT is indicated on the top of each bar.</p

Incidence and adjusted hazard ratio of peripheral arterial disease by sex, age and comorbidity for Schizophrenia patients compared to controls.

<p>Incidence and adjusted hazard ratio of peripheral arterial disease by sex, age and comorbidity for Schizophrenia patients compared to controls.</p

Cummulative incidence comparison of dementia for patients with (dashed line) or without (solid line) Irritable bowel syndrome.

<p>Cummulative incidence comparison of dementia for patients with (dashed line) or without (solid line) Irritable bowel syndrome.</p

Incidence and hazard ratio of peripheral arterial occlusive disease for schizophrenia patients with treatment compared with non-schizophrenia subjects.

<p>Incidence and hazard ratio of peripheral arterial occlusive disease for schizophrenia patients with treatment compared with non-schizophrenia subjects.</p

PPAR-dependent bioluminescence in living mice and individual organs after chitosan administration.

<p>(A) Time course. Transgenic mice were subcutaneously injected saline (mock) or chitosan, and images at indicated periods. Results are expressed as relative intensity, which is presented as comparison with the luminescent intensity relative to mock. Values are mean ± standard error (<i>n</i>=6 per group). (B) <i>Ex vivo</i> imaging and quantification of photon emission from individual organs. Transgenic mice were subcutaneously injected saline (mock) or chitosan, and sacrificed 3 days later for organ imaging. Values are mean ± standard error (<i>n</i>=6 per group). *<i>p</i><0.05, ***<i>p</i><0.001, compared with mock. The color overlay on the image represents the photon/sec emitted from the organs, as indicated by the color scale. Photos are representative images.</p