Assessing the suitability of medial sural artery perforator flaps in tongue reconstruction – An outcome study - Fig 2

<p>(a) Intraoperative photograph demonstrating a subtotal hemiglossectomy defect. (b) Intraoperative harvest of a large MSAP flap from an overweight patient. The MSAP flap was of a suitable size for reconstruction of a subtotal glossectomy defect. (c) Photograph demonstrating the inset of the MSAP flap with good contouring and restoration of tongue form.</p

Demographics of patients.

<p>Demographics of patients.</p

Flap details.

<p>Flap details.</p

Outcomes and complications.

<p>Outcomes and complications.</p

Assessment of donor site scar.

<p>Assessment of donor site scar.</p

Postoperative photograph of a hemiglossectomy defect reconstructed with a MSAP flap.

<p>Postoperative photograph of a hemiglossectomy defect reconstructed with a MSAP flap.</p

Synthesis of Two-Dimensional (Cu–S)<i>_n</i> Metal–Organic Framework Nanosheets Applied as Peroxidase Mimics for Detection of Glutathione

Facilely synthesized peroxidase-like nanozymes with high catalytic activity and stability may serve as effective biocatalysts. The present study synthesizes peroxidase-like nanozymes with multinuclear active sites using two-dimensional (2D) metal–organic framework (MOF) nanosheets and evaluates them for their practical applications. A simple method involving a one-pot bottom-up reflux reaction is developed for the mass synthesis of (Cu–S)n MOF 2D nanosheets, significantly increasing production quantity and reducing reaction time compared to traditional autoclave methods. The (Cu–S)n MOF 2D nanosheets with the unique coordination of Cu(I) stabilized in Cu-based MOFs demonstrate impressive activity in mimicking natural peroxidase. The active sites of the peroxidase-like activity of (Cu–S)n MOF 2D nanosheets were predominantly verified as Cu(I) rather than Cu(II) of other Cu-based MOFs. The cost-effective and long-term stability of (Cu–S)n MOF 2D nanosheets make them suitable for practical applications. Furthermore, the inhibition of the peroxidase-like activity of (Cu–S)n MOF nanosheets by glutathione (GSH) could provide a simple strategy for colorimetric detection of GSH against other amino acids. This work remarkably extends the utilization of (Cu–S)n MOF 2D nanosheets in biosensing, revealing the potential for 2D (Cu–S)n MOFs