Meta-analysis for the association of rs1883832 with coronary artery disease in Chinese population.

<p>Abbreviation: CAD, coronary artery disease; OR, odds ratio; M-H, Mantel-Haenszel method.</p

The SNP rs1883832 in CD40 Gene and Risk of Atherosclerosis in Chinese Population: A Meta-Analysis

<div><p>Background</p><p>The complications of atherosclerosis such as coronary and cerebrovascular disease, are the most prevalent causes of mortality and morbidity worldwide. A single nucleotide polymorphism (SNP) rs1883832 (-1C/T) in CD40 gene has been recently suggested to contribute to the susceptibility to atherosclerosis in Chinese population; however, previous genetic association studies yielded inconsistent results.</p><p>Methods</p><p>A meta-analysis of eligible studies reporting the association between rs1883832 and atherosclerosis in Chinese population was carried out.</p><p>Results</p><p>Pooling 7 eligible case-control studies involving 2129 patients and 1895 controls demonstrated a significant association between rs1883832 and atherosclerosis under dominant model [odds ratio (OR) = 1.631, 95% confidence interval [CI] [1.176, 2.260] in Chinese population with evident heterogeneity. Meta-regression analysis indicated that the heterogeneity could be completely explained by disease category. In subgroup analysis, rs1883832 conferred ORs of 2.866 (C/C versus T/T, 95%CI [2.203, 3.729]) and 1.680 (C/T versus T/T, 95%CI [1.352, 2.086]) for coronary artery disease (CAD) under co-dominant model without heterogeneity. Similar results were obtained for acute coronary syndrome (ACS) (C/C versus T/T, 3.674, 95%CI [2.638, 5.116]; C/T versus T/T, 1.981, 95%CI [1.483, 2.646]). The other genetic models including dominant, recessive and additive models, yielded consistent results without heterogeneity for CAD and ACS, respectively. However, a protective role was found for C allele in ischemic stroke (IS) under recessive model (0.582, 95%CI [0.393, 0.864]) and additive model (0.785, 95%CI [0.679, 0.909]) with reduced heterogeneity.</p><p>Conclusions</p><p>This meta-analysis provided evidence of association of rs1883832 C allele with an overall increased risk of atherosclerosis but distinct effect of C allele on CAD (including ACS) and IS in Chinese population, respectively.</p></div

The PRISMA recommended flow-diagram depicting the methodology of article selection for this meta-analysis.

<p>The PRISMA recommended flow-diagram depicting the methodology of article selection for this meta-analysis.</p

Sensitivity analysis.

<p>Abbreviation: OR, odds ratio; 95%CI, 95% confidence interval; IS, is chemic stroke; CAD, coronary artery disease.</p

Meta-analysis for the association of rs1883832 with atherosclerosis.

<p>Included publications: CAD: Li Y, 2007; Wang CP, 2009; Tian CX, 2010; Yan JC, 2010; Wang M, 2011; IS or CI:</p><p>Ma Y, 2013; Zhang BK, 2013.</p><p>Likelihood ratio test: LR = 23.82, P<0.001.</p><p>Pooled C allele frequency: 46.8% (41.1%–52.5%), P heterogeneity<0.001, I² = 91.5%.</p><p>Abbreviation: ACS, acute coronary syndrome; CAD coronary artery disease; IS, ischemic stroke; CI, cerebral infarction;</p><p>OR, odds ratio; 95% CI, 95% confidence interval.</p

Meta-analysis for the association of rs1883832 with acute coronary syndrome.

<p>Included publications: Li Y, 2007; Tian CX, 2010; Yan JC, 2010; Wang M, 2011.</p><p>Likelihood ratio test: LR = 62.64, P<0.001.</p><p>Abbreviation: ACS, acute coronary syndrome; OR, odds ratio; 95%CI, 95% confidence interval.</p

Meta-analysis for the association of rs1883832 with ischemic stroke.

<p>Included publications: Ma Y, 2013; Zhang BK,2013.</p><p>Likelihood ratio test: LR = 22.04, P<0.001.</p><p>Pooled C allele frequency: 49.9% (31.9%–67.8%), P heterogeneity<0.001, I² = 98.4%.</p><p>Abbreviation: IS, ischemic stroke; OR, odds ratio; 95%CI, 95% confidence interval.</p

The characteristics of the studies included in the meta-analysis for the association of rs1883832 with atherosclerosis.

<p>Abbreviation: PCR-RFLP, polymerase chain reaction-restriction fragment length polymorphism; ACS, acute coronary syndrome; CAD coronary artery disease;</p><p>SA, stable angina; IS, ischemic stroke; CI, cerebral infarction.</p><p>Symbols: ‘*’ indicates the study on coronary artery disease; ‘^#’ indicates the study on ischemic disease.</p

Meta-analysis for the association of rs1883832 with atherosclerosis and ischemic stroke in Chinese population.

<p>Abbreviation: IS, ischemic stroke; M-H, Mantel-Haenszel method.</p

Distribution of genotypes and alleles in the individual study.

<p>Abbreviation: HWE, Hardy-Weinberg equilibrium.</p