RISK and BIOSAFETY OF MODERN BIOTECHNOLOGIES Trans-disciplinary approach. Study guide for students majoring in "molecular biology and biotechnology"

The guide explains the basic concepts of natural, social and evolutionary components and methods of risk management and control of modern biotechnologies stemming from the general theory of human evolution. A a transdisciplinary approach is a feature of the presentation of the material The risk is considered from the point of view of evolutionary anthropology, as a basic element of a stable evolutionary strategy of our biological species and the basis of a combination of natural-scientific and humanitarian forms of presentation and interpretation of the material. CONTENT BIOSAFETY AND BIOETHICS IN BIOTECHNOLOGY (Introduction). Part 1. BIOTECHNOLOGY AS A FACTOR OF EVOLUTION AND A SOURCE OF TECHNOGENIC RISK. Chapter 1. GENERAL THEORY OF TECHNOLOGICAL RISK. Chapter 2. RISK AS AN ATTRIBUTE OF STABLE HUMAN EVOLUTIONARY STRATEGY. Chapter 3. BIOTECHNOLOGY AS A SOURCE OF BIORISKS Chapter 4. COMPONENTS OF THE "BIOLOGICAL FACTOR" OF RISK. Chapter 5. BIOLOGICAL WEAPONS and BIOTERRORISM. Part 2. BIOLOGICAL, SOCIAL AND EVOLUTIONARY COMPONENTS OF THE RISK OF MODERN BIOTECHNOLOGIES Chapter 6. RISK MANAGEMENT DURING BIOTECHNOLOGICAL RESEARCH.. Chapter 7. BIOTECHNOLOGY AS A SOURCE OF SOCIAL INSTABILITY. Chapter 8. BIOTECHNOLOGY AS A SOURCE OF CIVILIZATIONAL RISK

Configuration of Stable Evolutionary Strategy of Homo Sapiens and Evolutionary Risks of Technological Civilization (the Conceptual Model Essay)

Stable evolutionary strategy of Homo sapiens (SESH) is built in accordance with the modular and hierarchical principle and consists of the same type of self-replicating elements, i.e. is a system of systems. On the top level of the organization of SESH is the superposition of genetic, social, cultural and techno-rationalistic complexes. The components of this triad differ in the mechanism of cycles of generation - replication - transmission - fixing/elimination of adoptively relevant information. This mechanism is implemented either in accordance with the Darwin-Weismann modus, or according to the Lamarck modus, the difference between them is clear from the title. The integral attribute of the system of systems including ESSH is the production of evolutionary risks. The sources of evolutionary risk for stable adaptive strategy of Homo sapiens are the imbalance of (1) the intra-genomic co-evolution (intragenomic conflicts); (2) the gene-cultural co- evolution; (3) the inter-cultural co-evolution; (4) techno-humanitarian balance; (5) inter- technological conflicts (technological traps). At least phenomenologically the components of the evolutionary risk are reversible, but in the aggregate they are in potentio irreversible destructive ones for bio-social, and cultural self-identity of Homo sapiens. When the actual evolution is the subject of a rationalist control and/or manipulation, the magnitude of the 4th and 5th components of the evolutionary risk reaches the level of existential significance

Influence of the microwave radiation of different polarization state on transinactivation effect and viability of Drosophila

The influence of microwave radiation (λ = 3.8 mm, intensity P = 0.1 mW/cm2) on stocks and hybrids of Drosophila melanogaster was investigated. Irradiation at the egg stage negatively influences the reproductive ability and output of the imago, and induces significant changes in the eye pigmentation of the imago. The effect of radiation depends on the state of polarization of the radiation. Linearly polarized radiation and left circularly polarized radiation induce a decrease of pigmentation, right circularly polarized radiation induces an increase of it. As the amount of the pigment is connected with manifestation of the transinactivation effect and the reinforcement of the transinactivation effect is connected with an increase of the conjugation of homologous chromosomes, the authors draw the conclusion that left polarized radiation and linearly polarized radiation cause the reinforcement of the transinactivation effect. The authors suppose that the observed effect is connected with an increase of chromosome conjugation in the interphase nucleus; the action of the right circularly polarized radiation is connected with a reduction of the effect of transinactivation that, in its turn, is connected with a reduction of the conjugation of homologous chromosomes in the interphase nucleus