Evidence for kappa Meson Production in J/psi -> bar{K}^*(892)^0K^+pi^- Process

Based on 58 million BESII J/psi events, the bar{K}^*(892)^0K^+pi^- channel in K^+K^-pi^+pi^- is studied. A clear low mass enhancement in the invariant mass spectrum of K^+pi^- is observed. The low mass enhancement does not come from background of other J/psi decay channels, nor from phase space. Two independent partial wave analyses have been performed. Both analyses favor that the low mass enhancement is the kappa, an isospinor scalar resonant state. The average mass and width of the kappa in the two analyses are 878 +- 23^{+64}_{-55} MeV/c^2 and 499 +- 52^{+55}_{-87} MeV/c^2, respectively, corresponding to a pole at (841 +- 30^{+81}_{-73}) - i(309 +- 45^{+48}_{-72}) MeV/c^2.Comment: 17 pages, 5 figure

Severe Asthma Standard-of-Care Background Medication Reduction With Benralizumab: ANDHI in Practice Substudy

peer reviewedBackground: The phase IIIb, randomized, parallel-group, placebo-controlled ANDHI double-blind (DB) study extended understanding of the efficacy of benralizumab for patients with severe eosinophilic asthma. Patients from ANDHI DB could join the 56-week ANDHI in Practice (IP) single-arm, open-label extension substudy. Objective: Assess potential for standard-of-care background medication reductions while maintaining asthma control with benralizumab. Methods: Following ANDHI DB completion, eligible adults were enrolled in ANDHI IP. After an 8-week run-in with benralizumab, there were 5 visits to potentially reduce background asthma medications for patients achieving and maintaining protocol-defined asthma control with benralizumab. Main outcome measures for non–oral corticosteroid (OCS)-dependent patients were the proportions with at least 1 background medication reduction (ie, lower inhaled corticosteroid dose, background medication discontinuation) and the number of adapted Global Initiative for Asthma (GINA) step reductions at end of treatment (EOT). Main outcomes for OCS-dependent patients were reductions in daily OCS dosage and proportion achieving OCS dosage of 5 mg or lower at EOT. Results: For non–OCS-dependent patients, 53.3% (n = 208 of 390) achieved at least 1 background medication reduction, increasing to 72.6% (n = 130 of 179) for patients who maintained protocol-defined asthma control at EOT. A total of 41.9% (n = 163 of 389) achieved at least 1 adapted GINA step reduction, increasing to 61.8% (n = 110 of 178) for patients with protocol-defined EOT asthma control. At ANDHI IP baseline, OCS dosages were 5 mg or lower for 40.4% (n = 40 of 99) of OCS-dependent patients. Of OCS-dependent patients, 50.5% (n = 50 of 99) eliminated OCS and 74.7% (n = 74 of 99) achieved dosages of 5 mg or lower at EOT. Conclusions: These findings demonstrate benralizumab's ability to improve asthma control, thereby allowing background medication reduction. © 202