In vitro anti-HIV activity of sulfated cell-wall polysaccharides from gametic, carposporic and tetrasporic stages of the mediterranean red alga Asparagopsis armata

International audienc

Anti-HIV activity and mode of action, in vitro, of the sulfated polysaccharide from Schizymenia dubyi (Rhodophyta)

International audienceThe water-soluble sulfated polysaccharide obtained from the red seaweed Schizymenia dubyi (Gigartinales, Gymnophlaceae) inhibited in vitro the replication of the Human Immunodeficiency Virus (HIV) as measured by Reverse Transcriptase enzyme in cell free supernatant as well as HIV-induced syncitium formation at 5 mu g/ml. To determine their optimal effect, the sulfated polysaccharide had to be present 2 h before or 1 h during the initial virus adsorption period. The action involved inhibition of virus-host cell attachment or an early step of HIV infection

Composition and antiviral activities of a sulfated polysaccharide from Schizymenia dubyi (Rhodophyta, Gigartinales)

38 ref.International audienc

Annual variation in composition and in vitro anti-HIV-1 activity of the sulfated glucuronogalactan from Schizymenia dubyi (Rhodophyta, Gigartinales)

International audienceAn account is given of the annual variation in composition andin vitro anti-HIV-1 activity of the water-soluble sulfated glucuronogalactan fromSchizymenia dubyi collected in Sicily. No marked variation seasonal chemical or physico-chemical features was observed, with the exception of L-galactose residues and viscosity. Evaluation of the anti-HIV-1 effect of the polysaccharide indicated that syncitial formation and HIV-associated reverse transcriptasein vitro were completely suppressed at 5 µg ml–1 by alga collected during the summer/spring period. This high anti-HIV-1 activity corresponded with a decrease in L-galactose, viscosity and sulfate content of the polysaccharide

Synthesis and antiviral activity of new anti-HIV amprenavir bioisosteres

International audienc