21 research outputs found
Characterizatio o a peptide adduct fouct by N
No full textAminoRIRIoIRIooI8R--I88RI888I b]pyridine (PhIP) is a membero a classo cossI0;q knos as theheteroNIH38 amines (HCAs) that arefo8RA in meat duringcoingIM It is amulti-o3RM carcino3R inro0AR-- fo0A adducts and with DNA and proI;33 Altho33 pro33 adducts are no tho8qq to beinvoq3M in cancerdevelo0R;3I they may be useful as internaldornalI;R o PhIPexpoAM8 andbioM;N8IH0qRM TooM; thegoIM o characterizing the adductsfouct in humans and thedevelo0IH0 o an assayfo quantitatio o adduct levels, we have characterized a peptide adduct fouct by the putative genoiveI metaboI33; N - aceto0IH0N--0 AmoN8 peptide with the internal sequenceLeu--Gln--Lys--Cys--ProIo-- which isho830MIH0 to apoqMNRIH target sequencefo HCAs in human serum albumin, was reacted with N-acetoH03A0N and an adduct was identified and further characterized by LC--ESI-MS/MS
Participation of the iron-sulfur cluster loop (FCL) motif of the adenine glycosylase MutY in DNA damage recognition and repair
No full textCompetitive Inhibition of Uracil DNA Glycosylase by a Modified Nucleotide Whose Triphosphate is a Substrate for DNA Polymerase
No full textRecognition of the Nonpolar Base 4-Methylindole in DNA by the DNA Repair Adenine Glycosylase MutY
No full textStandard Role for a Conserved Aspartate or More Direct Involvement in Deglycosylation? An ONIOM and MD Investigation of Adenine–DNA Glycosylase
No full textCapturing Labile Sulfenamide and Sulfinamide Serum Albumin Adducts of Carcinogenic Arylamines by Chemical Oxidation
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Linear Free Energy Correlations for Enzymatic Base Flipping: How Do Damaged Base Pairs Facilitate Specific Recognition?
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