Physical and chemical properties and beta carotene encapsulation of water soluble molecular rearrangement glucans synthesized by amylosucrase

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Molecular docking and kinetic study of transglycosylation reaction for naringenin using amylosucrase from Deinococcus wulumuqiensis

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Trib2 regulates the pluripotency of embryonic stem cells and enhances reprogramming efficiency

Embryonic stem (ES) cells are pluripotent cells characterized by self-renewability and differentiation potential. Induced pluripotent stem (iPS) cells are ES cell-equivalent cells derived from somatic cells by the introduction of core reprogramming factors. ES and iPS cells are important sources for understanding basic biology and for generating therapeutic cells for clinical applications. Tribbles homolog 2 (Trib2) functions as a scaffold in signaling pathways. However, the relevance of Trib2 to the pluripotency of ES and iPS cells is unknown. In the present study, we elucidated the importance of Trib2 in maintaining pluripotency in mouse ES cells and in generating iPS cells from somatic cells through the reprogramming process. Trib2 expression decreased as ES cells differentiated, and Trib2 knockdown in ES cells changed their colony morphology while reducing the activity of alkaline phosphatase and the expression of the pluripotency marker genes Oct4, Sox2, Nanog and Klf4. Trib2 directly interacted with Oct4 and elevated Oct4 promoter activity. During the generation of iPS cells, Trib2 knockdown decreased the reprogramming efficiency of mouse embryonic fibroblasts, whereas Trib2 overexpression significantly increased their reprogramming efficiency. In summary, our results suggest that Trib2 is important for maintaining self-renewal in ES cells and for pluripotency induction during the reprogramming process

Monocrotophos: dimethyl (E)-1-methyl-2-(methyl­carbamo­yl)ethenyl phosphate

In the title compound, C7H14NO5P, the phosphate group displays rotational disorder of three O atoms with an occupancy ratio of 0.832 (6):0.167 (6). The dihedral angle between the acryl­amide group and PO2 plane of the phosphate group is 75.69 (7)°. In the crystal, inter­molecular N—H⋯O and C—H⋯O hydrogen bonds link the molecules

Toward Practical Privacy-Preserving Convolutional Neural Networks Exploiting Fully Homomorphic Encryption

Incorporating fully homomorphic encryption (FHE) into the inference process of a convolutional neural network (CNN) draws enormous attention as a viable approach for achieving private inference (PI). FHE allows delegating the entire computation process to the server while ensuring the confidentiality of sensitive client-side data. However, practical FHE implementation of a CNN faces significant hurdles, primarily due to FHE's substantial computational and memory overhead. To address these challenges, we propose a set of optimizations, which includes GPU/ASIC acceleration, an efficient activation function, and an optimized packing scheme. We evaluate our method using the ResNet models on the CIFAR-10 and ImageNet datasets, achieving several orders of magnitude improvement compared to prior work and reducing the latency of the encrypted CNN inference to 1.4 seconds on an NVIDIA A100 GPU. We also show that the latency drops to a mere 0.03 seconds with a custom hardware design.Comment: 3 pages, 1 figure, appears at DISCC 2023 (2nd Workshop on Data Integrity and Secure Cloud Computing, in conjunction with the 56th International Symposium on Microarchitecture (MICRO 2023)

Phosmet: O,O-dimethyl S-phthalimidomethyl phospho­rodithio­ate

In the title compound, C11H12NO4PS2, the dihedral angle between the phthalimidyl ring plane and the PS2 plane of the phospho­rodithio­ate group is 60.41 (3)°. In the crystal structure, weak inter­molecular C—H⋯O hydrogen bonds and S⋯S inter­actions [3.3825 (9) Å] contribute to the stabilization of the packing

Efficacy of early immunomodulator therapy on the outcomes of Crohn’s disease

BACKGROUND: The natural course of Crohn’s disease (CD), with continuing relapses and remissions, leads to irreversible intestinal damage. Early adoption of immunomodulator therapy has been proposed in order to address this; however, it is still uncertain whether early immunomodulator therapy could affect the natural course of the disease in real practice. We evaluated the efficacy of such therapy on the prognosis of newly diagnosed patients with CD. METHODS: This retrospective study included 168 patients who were newly diagnosed with CD and who started treatment at Severance Hospital, Seoul, Korea between January 2006 and March 2013. The short- and long-term outcomes were compared between patients treated with early immunomodulator therapy and those treated with conventional therapy. RESULTS: A Kaplan-Meier analysis identified that administration of immunomodulators within 6 months after diagnosis of CD was superior to conventional therapy in terms of clinical remission and corticosteroid-free remission rates (P=0.043 and P=0.035). However, P=0.827). Patients with a baseline elevated CRP level were more likely to relapse (P<0.005). Drug-related adverse events were more frequent in the early immunomodulator therapy group than in the conventional therapy group P=0.029). CONCLUSIONS: Early immunomodulator therapy was more effective than conventional therapy in inducing remission, but not in preventing relapse. Baseline high CRP level was a significant indicator of relapse

Recurrent Lower Gastrointestinal Bleeding from Congenital Arteriovenous Malformation in the Terminal Ileum Mimicking Intestinal Varicosis: A Case Report

We report on an exceptional vascular cause of gastrointestinal hemorrhage. A 30-yr-old man was admitted because of recurrent hematochezia. Colonoscopy showed circumferential, erythematous, and nodular vascular distensions with hematocystic spots in the terminal ileum resembling varicosis and subsequent computed tomography with 3-dimensional angiographic reconstruction revealed a vascular architecture around the terminal ileum. No other potential source of bleeding was identified. The patient was treated by ileocecectomy and the final diagnosis was of an arteriovenous malformation confined to the terminal ileum. He has been followed-up without a further hemorrhagic episode