L(sub 1) Adaptive Control Design for NASA AirSTAR Flight Test Vehicle

In this paper we present a new L(sub 1) adaptive control architecture that directly compensates for matched as well as unmatched system uncertainty. To evaluate the L(sub 1) adaptive controller, we take advantage of the flexible research environment with rapid prototyping and testing of control laws in the Airborne Subscale Transport Aircraft Research system at the NASA Langley Research Center. We apply the L(sub 1) adaptive control laws to the subscale turbine powered Generic Transport Model. The presented results are from a full nonlinear simulation of the Generic Transport Model and some preliminary pilot evaluations of the L(sub 1) adaptive control law

Studying Malicious Websites and the Underground Economy on the Chinese Web

The World Wide Web gains more and more popularity within China with more than 1.31 million websites on the Chinese Web in June 2007. Driven by the economic profits, cyber criminals are on the rise and use the Web to exploit innocent users. In fact, a real underground black market with thousand of participants has developed which brings together malicious users who trade exploits, malware, virtual assets, stolen credentials, and more. In this paper, we provide a detailed overview of this underground black market and present a model to describe the market. We substantiate our model with the help of measurement results within the Chinese Web. First, we show that the amount of virtual assets traded on this underground market is huge. Second, our research proofs that a significant amount of websites within China’s part of the Web are malicious: our measurements reveal that about 1.49% of the examined sites contain some kind of malicious content

PAI-Diffusion: Constructing and Serving a Family of Open Chinese Diffusion Models for Text-to-image Synthesis on the Cloud

Text-to-image synthesis for the Chinese language poses unique challenges due to its large vocabulary size, and intricate character relationships. While existing diffusion models have shown promise in generating images from textual descriptions, they often neglect domain-specific contexts and lack robustness in handling the Chinese language. This paper introduces PAI-Diffusion, a comprehensive framework that addresses these limitations. PAI-Diffusion incorporates both general and domain-specific Chinese diffusion models, enabling the generation of contextually relevant images. It explores the potential of using LoRA and ControlNet for fine-grained image style transfer and image editing, empowering users with enhanced control over image generation. Moreover, PAI-Diffusion seamlessly integrates with Alibaba Cloud's Machine Learning Platform for AI, providing accessible and scalable solutions. All the Chinese diffusion model checkpoints, LoRAs, and ControlNets, including domain-specific ones, are publicly available. A user-friendly Chinese WebUI and the diffusers-api elastic inference toolkit, also open-sourced, further facilitate the easy deployment of PAI-Diffusion models in various environments, making it a valuable resource for Chinese text-to-image synthesis

Adverse drug events associated with linezolid administration: a real-world pharmacovigilance study from 2004 to 2023 using the FAERS database

Introduction: Linezolid is an oxazolidinone antibiotic that is active against drug-resistant Gram-positive bacteria and multidrug-resistant Mycobacterium tuberculosis. Real-world studies on the safety of linezolid in large populations are lacking. This study aimed to determine the adverse events associated with linezolid in real-world settings by analyzing data from the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS).Methods: We retrospectively extracted reports on adverse drug events (ADEs) from the FAERS database from the first quarter of 2004 to that of 2023. By using disproportionality analysis including reporting odds ratio (ROR), proportional reporting ratio (PRR), Bayesian Confidence Propagation Neural Network (BCPNN), along with the multi-item gamma Poisson shrinker (MGPS), we evaluated whether there was a significant association between linezolid and ADE. The time to onset of ADE was further analyzed in the general population and within each age, weight, reporting population, and weight subgroups.Results: A total of 11,176 reports of linezolid as the “primary suspected” drug and 263 significant adverse events of linezolid were identified, including some common adverse events such as thrombocytopenia (n = 1,139, ROR 21.98), anaemia (n = 704, ROR 7.39), and unexpected signals that were not listed on the drug label such as rhabdomyolysis (n = 90, ROR 4.33), and electrocardiogram QT prolonged (n = 73, ROR 4.07). Linezolid-induced adverse reactions involved 27 System Organ Class (SOC). Gender differences existed in ADE signals related to linezolid. The median onset time of all ADEs was 6 days, and most ADEs (n = 3,778) occurred within the first month of linezolid use but some may continue to occur even after a year of treatment (n = 46).Conclusion: This study reports the time to onset of adverse effects in detail at the levels of SOC and specific preferred term (PT). The results of our study provide valuable insights for optimizing the use of linezolid and reducing potential side effects, expected to facilitate the safe use of linezolid in clinical settings

ASFL-YOLOX: an adaptive spatial feature fusion and lightweight detection method for insect pests of the Papilionidae family

IntroductionInsect pests from the family Papilionidae (IPPs) are a seasonal threat to citrus orchards, causing damage to young leaves, affecting canopy formation and fruiting. Existing pest detection models used by orchard plant protection equipment lack a balance between inference speed and accuracy.MethodsTo address this issue, we propose an adaptive spatial feature fusion and lightweight detection model for IPPs, called ASFL-YOLOX. Our model includes several optimizations, such as the use of the Tanh-Softplus activation function, integration of the efficient channel attention mechanism, adoption of the adaptive spatial feature fusion module, and implementation of the soft Dlou non-maximum suppression algorithm. We also propose a structured pruning curation technique to eliminate unnecessary connections and network parameters.ResultsExperimental results demonstrate that ASFL-YOLOX outperforms previous models in terms of inference speed and accuracy. Our model shows an increase in inference speed by 29 FPS compared to YOLOv7-x, a higher mAP of approximately 10% than YOLOv7-tiny, and a faster inference frame rate on embedded platforms compared to SSD300 and Faster R-CNN. We compressed the model parameters of ASFL-YOLOX by 88.97%, reducing the number of floating point operations per second from 141.90G to 30.87G while achieving an mAP higher than 95%.DiscussionOur model can accurately and quickly detect fruit tree pest stress in unstructured orchards and is suitable for transplantation to embedded systems. This can provide technical support for pest identification and localization systems for orchard plant protection equipment