Distances to the Supernova Remnants in the Inner Disk

Distance measurements of supernova remnants (SNRs) are essential and important. Accurate estimates of physical size, dust masses, and some other properties of SNRs depend critically on accurate distance measurements. However, the determination of SNR distances is still a tough task. Red clump stars (RCs) have a long history been used as standard candles. In this work, we take RCs as tracers to determine the distances to a large group of SNRs in the inner disk. We first select RC stars based on the near-infrared (IR) color-magnitude diagram (CMD). Then, the distance to and extinction of RC stars are calculated. To extend the measurable range of distance, we combine near-IR photometric data from the 2MASS survey with the deeper UKIDSS and VVV surveys. With the help of the Gaia parallaxes, we also remove contaminants including dwarfs and giants. Because an SN explosion compresses the surrounding interstellar medium, the SNR region would become denser and exhibit higher extinction than the surroundings. The distance of a SNR is then recognized by the position where the extinction and its gradient is higher than that of the ambient medium. A total of 63 SNRs' distances in the Galactic inner disk are determined and divided into three Levels A, B, and C with decreasing reliability. The distances to 43 SNRs are well determined with reliability A or B. The diameters and dust masses of SNRs are estimated with the obtained distance and extinction.Comment: 31 pages, 25 figures, 2 tables, accepted for publication in A&

Bridging Discrete and Backpropagation: Straight-Through and Beyond

Backpropagation, the cornerstone of deep learning, is limited to computing gradients solely for continuous variables. This limitation hinders various research on problems involving discrete latent variables. To address this issue, we propose a novel approach for approximating the gradient of parameters involved in generating discrete latent variables. First, we examine the widely used Straight-Through (ST) heuristic and demonstrate that it works as a first-order approximation of the gradient. Guided by our findings, we propose a novel method called ReinMax, which integrates Heun's Method, a second-order numerical method for solving ODEs, to approximate the gradient. Our method achieves second-order accuracy without requiring Hessian or other second-order derivatives. We conduct experiments on structured output prediction and unsupervised generative modeling tasks. Our results show that \ours brings consistent improvements over the state of the art, including ST and Straight-Through Gumbel-Softmax. Implementations are released at https://github.com/microsoft/ReinMax.Comment: Work in progres

Boosting In-Context Learning with Factual Knowledge

In-Context Learning (ICL) over Large language models (LLMs) aims at solving previously unseen tasks by conditioning on a few training examples, eliminating the need for parameter updates and achieving competitive performance. In this paper, we demonstrate that factual knowledge is imperative for the performance of ICL in three core facets, i.e., the inherent knowledge learned in LLMs, the factual knowledge derived from the selected in-context examples, and the knowledge biases in LLMs for output generation. To unleash the power of LLMs in few-shot learning scenarios, we introduce a novel Knowledgeable In-Context Tuning (KICT) framework to further improve the performance of ICL: 1) injecting factual knowledge to LLMs during continual self-supervised pre-training, 2) judiciously selecting the examples with high knowledge relevance, and 3) calibrating the prediction results based on prior knowledge. We evaluate the proposed approaches on auto-regressive LLMs (e.g., GPT-style models) over multiple text classification and question answering tasks. Experimental results demonstrate that KICT substantially outperforms strong baselines, and improves by more than 13% and 7% of accuracy on text classification and question answering tasks, respectively

A Causal Intervention Scheme for Semantic Segmentation of Quasi-periodic Cardiovascular Signals

Precise segmentation is a vital first step to analyze semantic information of cardiac cycle and capture anomaly with cardiovascular signals. However, in the field of deep semantic segmentation, inference is often unilaterally confounded by the individual attribute of data. Towards cardiovascular signals, quasi-periodicity is the essential characteristic to be learned, regarded as the synthesize of the attributes of morphology (Am) and rhythm (Ar). Our key insight is to suppress the over-dependence on Am or Ar while the generation process of deep representations. To address this issue, we establish a structural causal model as the foundation to customize the intervention approaches on Am and Ar, respectively. In this paper, we propose contrastive causal intervention (CCI) to form a novel training paradigm under a frame-level contrastive framework. The intervention can eliminate the implicit statistical bias brought by the single attribute and lead to more objective representations. We conduct comprehensive experiments with the controlled condition for QRS location and heart sound segmentation. The final results indicate that our approach can evidently improve the performance by up to 0.41% for QRS location and 2.73% for heart sound segmentation. The efficiency of the proposed method is generalized to multiple databases and noisy signals.Comment: submitted to IEEE Journal of Biomedical and Health Informatics (J-BHI

ECG-CL: A Comprehensive Electrocardiogram Interpretation Method Based on Continual Learning

Electrocardiogram (ECG) monitoring is one of the most powerful technique of cardiovascular disease (CVD) early identification, and the introduction of intelligent wearable ECG devices has enabled daily monitoring. However, due to the need for professional expertise in the ECGs interpretation, general public access has once again been restricted, prompting the need for the development of advanced diagnostic algorithms. Classic rule-based algorithms are now completely outperformed by deep learning based methods. But the advancement of smart diagnostic algorithms is hampered by issues like small dataset, inconsistent data labeling, inefficient use of local and global ECG information, memory and inference time consuming deployment of multiple models, and lack of information transfer between tasks. We propose a multi-resolution model that can sustain high-resolution low-level semantic information throughout, with the help of the development of low-resolution high-level semantic information, by capitalizing on both local morphological information and global rhythm information. From the perspective of effective data leverage and inter-task knowledge transfer, we develop a parameter isolation based ECG continual learning (ECG-CL) approach. We evaluated our model's performance on four open-access datasets by designing segmentation-to-classification for cross-domain incremental learning, minority-to-majority class for category incremental learning, and small-to-large sample for task incremental learning. Our approach is shown to successfully extract informative morphological and rhythmic features from ECG segmentation, leading to higher quality classification results. From the perspective of intelligent wearable applications, the possibility of a comprehensive ECG interpretation algorithm based on single-lead ECGs is also confirmed.Comment: 10 page

TransPrompt v2: A Transferable Prompting Framework for Cross-task Text Classification

Text classification is one of the most imperative tasks in natural language processing (NLP). Recent advances with pre-trained language models (PLMs) have shown remarkable success on this task. However, the satisfying results obtained by PLMs heavily depend on the large amounts of task-specific labeled data, which may not be feasible in many application scenarios due to data access and privacy constraints. The recently-proposed prompt-based fine-tuning paradigm improves the performance of PLMs for few-shot text classification with task-specific templates. Yet, it is unclear how the prompting knowledge can be transferred across tasks, for the purpose of mutual reinforcement. We propose TransPrompt v2, a novel transferable prompting framework for few-shot learning across similar or distant text classification tasks. For learning across similar tasks, we employ a multi-task meta-knowledge acquisition (MMA) procedure to train a meta-learner that captures the cross-task transferable knowledge. For learning across distant tasks, we further inject the task type descriptions into the prompt, and capture the intra-type and inter-type prompt embeddings among multiple distant tasks. Additionally, two de-biasing techniques are further designed to make the trained meta-learner more task-agnostic and unbiased towards any tasks. After that, the meta-learner can be adapted to each specific task with better parameters initialization. Extensive experiments show that TransPrompt v2 outperforms single-task and cross-task strong baselines over multiple NLP tasks and datasets. We further show that the meta-learner can effectively improve the performance of PLMs on previously unseen tasks. In addition, TransPrompt v2 also outperforms strong fine-tuning baselines when learning with full training sets

SAR-to-Optical Image Translation via Thermodynamics-inspired Network

Synthetic aperture radar (SAR) is prevalent in the remote sensing field but is difficult to interpret in human visual perception. Recently, SAR-to-optical (S2O) image conversion methods have provided a prospective solution for interpretation. However, since there is a huge domain difference between optical and SAR images, they suffer from low image quality and geometric distortion in the produced optical images. Motivated by the analogy between pixels during the S2O image translation and molecules in a heat field, Thermodynamics-inspired Network for SAR-to-Optical Image Translation (S2O-TDN) is proposed in this paper. Specifically, we design a Third-order Finite Difference (TFD) residual structure in light of the TFD equation of thermodynamics, which allows us to efficiently extract inter-domain invariant features and facilitate the learning of the nonlinear translation mapping. In addition, we exploit the first law of thermodynamics (FLT) to devise an FLT-guided branch that promotes the state transition of the feature values from the unstable diffusion state to the stable one, aiming to regularize the feature diffusion and preserve image structures during S2O image translation. S2O-TDN follows an explicit design principle derived from thermodynamic theory and enjoys the advantage of explainability. Experiments on the public SEN1-2 dataset show the advantages of the proposed S2O-TDN over the current methods with more delicate textures and higher quantitative results

Graph Convolutional Network with Connectivity Uncertainty for EEG-based Emotion Recognition

Automatic emotion recognition based on multichannel Electroencephalography (EEG) holds great potential in advancing human-computer interaction. However, several significant challenges persist in existing research on algorithmic emotion recognition. These challenges include the need for a robust model to effectively learn discriminative node attributes over long paths, the exploration of ambiguous topological information in EEG channels and effective frequency bands, and the mapping between intrinsic data qualities and provided labels. To address these challenges, this study introduces the distribution-based uncertainty method to represent spatial dependencies and temporal-spectral relativeness in EEG signals based on Graph Convolutional Network (GCN) architecture that adaptively assigns weights to functional aggregate node features, enabling effective long-path capturing while mitigating over-smoothing phenomena. Moreover, the graph mixup technique is employed to enhance latent connected edges and mitigate noisy label issues. Furthermore, we integrate the uncertainty learning method with deep GCN weights in a one-way learning fashion, termed Connectivity Uncertainty GCN (CU-GCN). We evaluate our approach on two widely used datasets, namely SEED and SEEDIV, for emotion recognition tasks. The experimental results demonstrate the superiority of our methodology over previous methods, yielding positive and significant improvements. Ablation studies confirm the substantial contributions of each component to the overall performance.Comment: 10 page

Deletion of FgHOG1 Is Suppressive to the mgv1 Mutant by Stimulating Gpmk1 Activation and Avoiding Intracellular Turgor Elevation in Fusarium graminearum

Fusarium head blight caused by Fusarium graminearum is an important disease of wheat and barley. Previous studies have showed that all three MAP kinase genes, MGV1, FgHOG1, and GPMK1, are involved in regulating hyphal growth, sexual reproduction, plant infection, and stress responses in this pathogen. To determine the relationship between the Mgv1 and FgHog1 pathways, in this study, we generated and characterized the mgv1 Fghog1 double mutant. Deletion of FgHOG1 partially rescued the defects of the mgv1 mutant in vegetative growth and cell wall integrity but had no effects on its defects in plant infection and DON production. The mgv1 Fghog1 mutant grew faster and was more tolerant to cell wall stressors than the mgv1 mutant. Swollen compartments and cell burst were observed frequently in the mgv1 mutant but rarely in the mgv1 Fghog1 mutant when treated with fungicide fludioxonil or cell wall stressor Congo red. Conversely, the deletion of MGV1 also alleviated the hyperosmotic sensitivity of the Fghog1 mutant in vegetative growth. TGY assays indicated increased phosphorylation of FgHog1 in the mgv1 mutant, and TEY assays further revealed elevated activation of Gpmk1 in the mgv1 Fghog1 double mutant, particularly under cell wall stress conditions. Overall, our data showed that deletion of FgHOG1 partially suppressed the defects of the mgv1 mutant, possibly by affecting genes related to cell wall integrity and osmoregulation via the over-activation of Gpmk1 MAP kinase and avoiding intracellular turgor elevation

GxcM-Fbp17/RacC-WASP signaling regulates polarized cortex assembly in migrating cells via Arp2/3

The actin-rich cortex plays a fundamental role in many cellular processes. Its architecture and molecular composition vary across cell types and physiological states. The full complement of actin assembly factors driving cortex formation and how their activities are spatiotemporally regulated remain to be fully elucidated. Using Dictyostelium as a model for polarized and rapidly migrating cells, we show that GxcM, a RhoGEF localized specifically in the rear of migrating cells, functions together with F-BAR protein Fbp17, a small GTPase RacC, and the actin nucleation-promoting factor WASP to coordinately promote Arp2/3 complex-mediated cortical actin assembly. Overactivation of this signaling cascade leads to excessive actin polymerization in the rear cortex, whereas its disruption causes defects in cortical integrity and function. Therefore, apart from its well-defined role in the formation of the protrusions at the cell front, the Arp2/3 complex-based actin carries out a previously unappreciated function in building the rear cortical subcompartment in rapidly migrating cells