Quark Potential in a Quark-Meson Plasma

We investigate quark potential by considering meson exchanges in the two flavor Nambu--Jona-Lasinio model at finite temperature and density. There are two kinds of oscillations in the chiral restoration phase, one is the Friedel oscillation due to the sharp quark Fermi surface at high density, and the other is the Yukawa oscillation driven by the complex meson poles at high temperature. The quark-meson plasma is strongly coupled in the temperature region $1\le T/T_c \lesssim 3$ with $T_c$ being the critical temperature of chiral phase transition. The maximum coupling in this region is located at the critical point.Comment: 8 pages and 8 figure

Decreased levels of active SMAD2 correlate with poor prognosis in gastric cancer.

BACKGROUND: TGF-β plays a dual role in the progression of human cancer. During the early stages of carcinogenesis, TGF-β functions as a tumor suppressor. During the late stages of tumor development, however, TGF-β can promote tumor growth and metastasis. A shift in Smad2/3 phosphorylation from the carboxy terminus to linker sites is a key event determining biological function of TGF-β in colorectal and hepatocellular carcinoma. In the present study, we investigated the potential role of differential Smad2/3 phosphorylation in gastric adenocarcinoma. METHODOLOGY: Immunohistochemical staining with anti-P-Smad2/3C and P-Smad2/3L antibodies was performed on 130 paraffin-embedded gastric adenocarcinoma specimens. The relationship between P-Smad2/3C and P-Smad2/3L immunohistochemical score and clinicopathologic characteristics of patients was analyzed. Real time PCR was used to measure mRNA expression of Smad2 and Smad3 in cancer and surrounding non-tumor tissue. PRINCIPAL FINDINGS: No significant P-Smad2L and/or P-Smad3L positive staining was detected in the majority of specimens (positive staining in 18/130 samples). Positive P-Smad2/3L staining was not associated with a decrease in carboxyterminal phosphorylation staining. Loss of P-Smad2C remarkably correlated with depth of tumor infiltration and poor differentiation of cancer cells in patients with gastric cancer. No correlation was detectable between P-Smad3C and clinicopathologic characteristics of gastric adenocarcinoma. However, co-staining analysis revealed that P-Smad3C co-localised with α-SMA and collagen I in gastric cancer cells, indicating a potential link between P-Smad3C and epithelial-to-mesenchymal transition of cancer. Real time PCR demonstrated reduced mRNA expression of Smad2 in gastric cancer when compared with surrounding non-tumor tissue in 15/16 patients. CONCLUSIONS: Loss of P-Smad2C tightly correlated with cancer invasion and poor differentiation in gastric cancer. Contrary to colorectal and hepatocellular carcinoma, canonical carboxy-terminal phosphorylation, but not linker phosphorylation, of Smad2 is critical for gastric cancer

P-Smad3C nuclear staining demonstrates a positive correlation with α-SMA expression in gastric cancer cells, but not in surrounding non-tumor tissues.

<p>Representative pictures from two patients with gastric cancer show α-SMA and P-Smad3C staining in cancer area (tumor) and surrounding non-cancer tissues (non-tumor).</p