1 research outputs found
Cell Environment-Differentiated Self-Assembly of Nanofibers
Employing cellular environment for
the self-assembly of supramolecular
nanofibers for biological applications has been widely explored. But
using one precursor to differentiate the extra- and intracellular
environments to self-assemble into two different nanofibers remains
challenging. With the knowledge that the extracellualr environment
of some cancer cells contains large amounts of alkaline phosphatase
(ALP) while their intracellular environment is glutathione (GSH)-abundant
in mind, we rationally designed a precursor Cys(SEt)-Glu-Tyr(H<sub>2</sub>PO<sub>3</sub>)-Phe-Phe-Gly-CBT (<b>1</b>) that can
efficiently yield amphiphilic <b>2</b> and <b>2-D</b> to
self-assemble into two different nanofibers in hydrogels under the
sequential treatment of ALP and GSH. We envision that, by employing
a click condensation reaction, this work offers a platform for facilely
postmodulation of supramolecular nanofibers, and the versatile precursor <b>1</b> could be used to kill two birds with one stone