Miraculous Survival of Three Trapping Miners by Drinking High Mineral Mine Water for 25

Little is known that how long a human been can survive a complete starvation. There were dozens of miners who lost their lives in a coal mine disaster at Qinglong,Guizhou,China in June 2009, only three of them were rescued 25 days later after they had been trapped in a coal mine 600 meters underground. They maintained their lives only by drinking mineral water in the mine, which created a miracle of life. We reported here on this life miracle in relation to high mineral mine water

trans-(2-Benzoyl­pyridine-κ2 N,O)dichlorido[2-(2-pyridylcarbon­yl)phenyl-κ2 C 1,N]iridium(III) dichloro­methane solvate

The title compound, [Ir(C12H8NO)Cl2(C12H9NO)]·CH2Cl2, which was obtained from the reaction of iridium(III) chloride trihydrate and 2-benzoyl­pyridine, contains an IrIII atom coordinated by two N, one O, one C and two Cl atoms in trans positions, forming a distorted octa­hedral environment. The solvent molecule CH2Cl2 is disordered over two positions with an occupancy of 0.8:0.2

Testosterone Depletion by Castration May Protect Mice from Heat-Induced Multiple Organ Damage and Lethality

When the vehicle-treated, sham-operated mice underwent heat stress, the fraction survival and core temperature at +4 h of body heating were found to be 5 of 15 and 34.4°C ± 0.3°C, respectively. Castration 2 weeks before the start of heat stress decreased the plasma levels of testosterone almost to zero, protected the mice from heat-induced death (fraction survival, 13/15) and reduced the hypothermia (core temperature, 37.3°C). The beneficial effects of castration in ameliorating lethality and hypothermia can be significantly reduced by testosterone replacement. Heat-induced apoptosis, as indicated by terminal deoxynucleotidyl- transferase- mediatedαUDP-biotin nick end-labeling staining, were significantly prevented by castration. In addition, heat-induced neuronal damage, as indicated by cell shrinkage and pyknosis of nucleus, to the hypothalamus was also castration-prevented. Again, the beneficial effects of castration in reducing neuronal damage to the hypothalamus as well as apoptosis in multiple organs during heatstroke, were significantly reversed by testosterone replacement. The data indicate that testosterone depletion by castration may protect mice from heatstroke-induced multiple organ damage and lethality

SCA-PVNet: Self-and-Cross Attention Based Aggregation of Point Cloud and Multi-View for 3D Object Retrieval

To address 3D object retrieval, substantial efforts have been made to generate highly discriminative descriptors of 3D objects represented by a single modality, e.g., voxels, point clouds or multi-view images. It is promising to leverage the complementary information from multi-modality representations of 3D objects to further improve retrieval performance. However, multi-modality 3D object retrieval is rarely developed and analyzed on large-scale datasets. In this paper, we propose self-and-cross attention based aggregation of point cloud and multi-view images (SCA-PVNet) for 3D object retrieval. With deep features extracted from point clouds and multi-view images, we design two types of feature aggregation modules, namely the In-Modality Aggregation Module (IMAM) and the Cross-Modality Aggregation Module (CMAM), for effective feature fusion. IMAM leverages a self-attention mechanism to aggregate multi-view features while CMAM exploits a cross-attention mechanism to interact point cloud features with multi-view features. The final descriptor of a 3D object for object retrieval can be obtained via concatenating the aggregated features from both modules. Extensive experiments and analysis are conducted on three datasets, ranging from small to large scale, to show the superiority of the proposed SCA-PVNet over the state-of-the-art methods

Attenuation of Acute Lung Inflammation and Injury by Whole Body Cooling in a Rat Heatstroke Model

Whole body cooling is the current therapy of choice for heatstroke because the therapeutic agents are not available. In this study, we assessed the effects of whole body cooling on several indices of acute lung inflammation and injury which might occur during heatstroke. Anesthetized rats were randomized into the following groups and given (a) no treatment or (b) whole body cooling immediately after onset of heatstroke. As compared with the normothermic controls, the untreated heatstroke rats had higher levels of pleural exudates volume and polymorphonuclear cell numbers, lung myloperoxidase activity and inducible nitric oxide synthase expression, histologic lung injury score, and bronchoalveolar proinflammatory cytokines and glutamate, and PaCO2. In contrast, the values of mean arterial pressure, heart rate, PaO2, pH, and blood HCO3− were all significantly lower during heatstroke. The acute lung inflammation and injury and electrolyte imbalance that occurred during heatstroke were significantly reduced by whole body cooling. In conclusion, we identified heat-induced acute lung inflammation and injury and electrolyte imbalance could be ameliorated by whole body cooling

Period-2: a tumor suppressor gene in breast cancer

Previous reports have suggested that the ablation of the Period 2 gene (Per 2) leads to enhanced development of lymphoma and leukemia in mice. Employing immunoblot analyses, we have demonstrated that PER 2 is endogenously expressed in human breast epithelial cell lines but is not expressed or is expressed at significantly reduced level in human breast cancer cell lines. Expression of PER 2 in MCF-7 breast cancer cells significantly inhibited the growth of MCF-7 human breast cancer cells, and, when PER 2 was co-expressed with the Crytochrome 2 (Cry 2) gene, an even greater growth-inhibitory effect was observed. The inhibitory effect of PER 2 on breast cancer cells was also demonstrated by its suppression of the anchorage-independent growth of MCF-7 cells as evidenced by the reduced number and size of colonies. A corresponding blockade of MCF-7 cells in the G1 phase of the cell cycle was also observed in response to the expression of PER 2 alone or in combination with CRY 2. Expression of PER 2 also induced apoptosis of MCF-7 breast cancer cells as demonstrated by an increase in PARP [poly (ADP-ribose) polymerase] cleavage. Finally, our studies demonstrate that PER 2 expression in MCF-7 breast cancer cells is associated with a significant decrease in the expression of cyclin D1 and an up-regulation of p53 levels

Roll-Coated Fabrication of Fullerene-Free Organic Solar Cells with Improved Stability

NSFC [91433114, 51261130582, 21025418]; 973 Program [2011CB808401]; Chinese Academy of Sciences; Danish National Research FoundationSCI(E)[email protected]; [email protected]