Systemic similarity analysis of compatibility drug-induced multiple pathway patterns _in vivo_

A major challenge in post-genomic research is to understand how physiological and pathological phenotypes arise from the networks of expressed genes and to develop powerful tools for translating the information exchanged between gene and the organ system networks. Although different expression modules may contribute independently to different phenotypes, it is difficult to interpret microarray experimental results at the level of single gene associations. The global effects and response pathways of small molecules in cells have been investigated, but the quantitative details of the activation mechanisms of multiple pathways _in vivo_ are not well understood. Similar response networks indicate similar modes of action, and gene networks may appear to be similar despite differences in the behaviour of individual gene groups. Here we establish the method for assessing global effect spectra of the complex signaling forms using Global Similarity Index (GSI) in cosines vector included angle. Our approach provides quantitative multidimensional measures of genes expression profile based on drug-dependent phenotypic alteration _in vivo_. These results make a starting point for identifying relationships between GSI at the molecular level and a step toward phenotypic outcomes at a system level to predict action of unknown compounds and any combination therapy

Features and stability analysis of non-Schwarzschild black hole in quadratic gravity

Black holes are found to exist in gravitational theories with the presence of quadratic curvature terms and behave differently from the Schwarzschild solution. We present an exhaustive analysis for determining the quasinormal modes of a test scalar field propagating in a new class of black hole backgrounds in the case of pure Einstein-Weyl gravity. Our result shows that the field decay of quasinormal modes in such a non-Schwarzschild black hole behaves similarly to the Schwarzschild one, but the decay slope becomes much smoother due to the appearance of the Weyl tensor square in the background theory. We also analyze the frequencies of the quasinormal modes in order to characterize the properties of new back holes, and thus, if these modes can be the source of gravitational waves, the underlying theories may be testable in future gravitational wave experiments. We briefly comment on the issue of quantum (in)stability in this theory at linear order.Comment: 18 pages, 4 figures, 1 table, several references added, version published on JHE