AD-related genes investigated in this study.

<p>AD-related genes investigated in this study.</p

Insulin signaling–related gene expressions in the hippocampus.

<p>Insulin signaling–related gene expressions in the hippocampus.</p

Comparison of altered AD-related gene expression profiles between the hippocampus and cerebral cortex.

<p>The relative levels of gene expression are shown, where those of the control mice are defined as 100. The hippocampal <i>Chat</i> data were excluded because of the high C_t values (30</p

Synapse-related gene expressions in the hippocampus.

<p>Synapse-related gene expressions in the hippocampus.</p

APP- and tau-related gene expressions.

<p>APP- and tau-related gene expressions.</p

Expressions of apoptosis- and autophagy-related genes and transcription factors in the hippocampus.

<p>Expressions of apoptosis- and autophagy-related genes and transcription factors in the hippocampus.</p

Immunohistochemical staining of E19d rat brain sections with antibody against OGT.

<p>Abbreviations: Amy, amygdala; Cox, cerebral cortex; Cpu, caudate putamen; cpu, caudate/putamen neuroepithelium; CxP, cortical plate; CxS, cortical subplate; ICx, intermediate cortical layer; LV, lateral ventricle; SubV, subventricular cortical layer.</p

Volcano plots of the gene expression changes in icv-STZ mice and 3xTg-AD mice.

<p>Fold changes (FC) in gene expression of icv-STZ mice vs. control mice (A) and 3xTg mice vs. control mice (B). Each dot represents one gene. Green, down-regulated; red, up-regulated.</p

Immunohistochemical staining of P5d rat brain sections with antibodies against OGT (A–G), OGA (H–N) and O-GlcNAc (P–U).

<p>Panels A, H and O are illustrations that represent the density of the immunostaining observed in various regions of the brain. Abbreviations: Amy, amygdala; CA cornu ammonis; Cox, cerebral cortex; Cpu, caudate putamen; Hip, hippocampus, Hy, hypothalamus; Py, pyramidal neurons, Th, thalamus. Scale bars  = 500 µm.</p

Glucose metabolism–related gene expressions in the hippocampus.

<p>Glucose metabolism–related gene expressions in the hippocampus.</p