Comparison of overall mortality rate in stage III breast cancer patients considering different baseline characteristics, after adjusting for age, sex, comorbidities, and medications before propensity score matching.

Comparison of overall mortality rate in stage III breast cancer patients considering different baseline characteristics, after adjusting for age, sex, comorbidities, and medications before propensity score matching.</p

Comparisons of mortality and recurrence rate between stage III breast cancer patients after propensity score matching.

Comparisons of mortality and recurrence rate between stage III breast cancer patients after propensity score matching.</p

Demographic characteristics of stage III breast cancer patients who received surgery in Taiwan (2010–2017).

Demographic characteristics of stage III breast cancer patients who received surgery in Taiwan (2010–2017).</p

The cumulative mortality rate among stage III breast cancer patients is lower with inhaled anesthetics (IA) compared to non-inhaled anesthetics (non-IA).

(A) Before propensity score matching; (B) After propensity score matching.</p

S2 Fig -

BackgroundPatients diagnosed with stage III breast cancer often undergo surgery, radiation therapy, and chemotherapy as part of their treatment. The choice of anesthesia technique during surgery has been a subject of interest due to its potential association with immune changes and prognosis. In this study, we aimed to compare the mortality rates between stage III breast cancer patients undergoing surgery with propofol-based intravenous general anesthesia and those receiving inhaled anesthetics.MethodsUsing data from Taiwan’s National Health Insurance Research Database and Taiwan Cancer Registry, we identified a cohort of 10,896 stage III breast cancer patients. Among them, 1,506 received propofol-based intravenous anesthetic maintenance, while 9,390 received inhaled anesthetic maintenance. To ensure comparability between the two groups, we performed propensity-score matching.ResultsOur findings revealed a significantly lower mortality rate in patients who received inhaled anesthetics compared to those who received propofol-based intravenous anesthesia. Sensitivity analysis further confirmed the robustness of our results.ConclusionsThis study suggests that inhaled anesthesia technique is associated with a lower mortality rate in clinical stage III breast cancer. Further research is needed to validate and expand upon these results.</div

S3 Fig -

BackgroundPatients diagnosed with stage III breast cancer often undergo surgery, radiation therapy, and chemotherapy as part of their treatment. The choice of anesthesia technique during surgery has been a subject of interest due to its potential association with immune changes and prognosis. In this study, we aimed to compare the mortality rates between stage III breast cancer patients undergoing surgery with propofol-based intravenous general anesthesia and those receiving inhaled anesthetics.MethodsUsing data from Taiwan’s National Health Insurance Research Database and Taiwan Cancer Registry, we identified a cohort of 10,896 stage III breast cancer patients. Among them, 1,506 received propofol-based intravenous anesthetic maintenance, while 9,390 received inhaled anesthetic maintenance. To ensure comparability between the two groups, we performed propensity-score matching.ResultsOur findings revealed a significantly lower mortality rate in patients who received inhaled anesthetics compared to those who received propofol-based intravenous anesthesia. Sensitivity analysis further confirmed the robustness of our results.ConclusionsThis study suggests that inhaled anesthesia technique is associated with a lower mortality rate in clinical stage III breast cancer. Further research is needed to validate and expand upon these results.</div

Topic overview.

Anesthesia techniques for curative surgery in stage III breast cancer can be categorized into two types: propofol-based maintenance or inhaled agent maintenance. This article aims to explore and compare the outcomes associated with these two techniques. Icon made by Freepik from www.flaticon.com.</p

S1 Fig -

BackgroundPatients diagnosed with stage III breast cancer often undergo surgery, radiation therapy, and chemotherapy as part of their treatment. The choice of anesthesia technique during surgery has been a subject of interest due to its potential association with immune changes and prognosis. In this study, we aimed to compare the mortality rates between stage III breast cancer patients undergoing surgery with propofol-based intravenous general anesthesia and those receiving inhaled anesthetics.MethodsUsing data from Taiwan’s National Health Insurance Research Database and Taiwan Cancer Registry, we identified a cohort of 10,896 stage III breast cancer patients. Among them, 1,506 received propofol-based intravenous anesthetic maintenance, while 9,390 received inhaled anesthetic maintenance. To ensure comparability between the two groups, we performed propensity-score matching.ResultsOur findings revealed a significantly lower mortality rate in patients who received inhaled anesthetics compared to those who received propofol-based intravenous anesthesia. Sensitivity analysis further confirmed the robustness of our results.ConclusionsThis study suggests that inhaled anesthesia technique is associated with a lower mortality rate in clinical stage III breast cancer. Further research is needed to validate and expand upon these results.</div

Flowchart of study population.

The study analyzed patients with stage III breast cancer who underwent surgical interventions from NHIRD and TCR databases after excluding ineligible cases.</p

S4 Fig -

BackgroundPatients diagnosed with stage III breast cancer often undergo surgery, radiation therapy, and chemotherapy as part of their treatment. The choice of anesthesia technique during surgery has been a subject of interest due to its potential association with immune changes and prognosis. In this study, we aimed to compare the mortality rates between stage III breast cancer patients undergoing surgery with propofol-based intravenous general anesthesia and those receiving inhaled anesthetics.MethodsUsing data from Taiwan’s National Health Insurance Research Database and Taiwan Cancer Registry, we identified a cohort of 10,896 stage III breast cancer patients. Among them, 1,506 received propofol-based intravenous anesthetic maintenance, while 9,390 received inhaled anesthetic maintenance. To ensure comparability between the two groups, we performed propensity-score matching.ResultsOur findings revealed a significantly lower mortality rate in patients who received inhaled anesthetics compared to those who received propofol-based intravenous anesthesia. Sensitivity analysis further confirmed the robustness of our results.ConclusionsThis study suggests that inhaled anesthesia technique is associated with a lower mortality rate in clinical stage III breast cancer. Further research is needed to validate and expand upon these results.</div