Rhythm-Flexible Voice Conversion without Parallel Data Using Cycle-GAN over Phoneme Posteriorgram Sequences

Speaking rate refers to the average number of phonemes within some unit time, while the rhythmic patterns refer to duration distributions for realizations of different phonemes within different phonetic structures. Both are key components of prosody in speech, which is different for different speakers. Models like cycle-consistent adversarial network (Cycle-GAN) and variational auto-encoder (VAE) have been successfully applied to voice conversion tasks without parallel data. However, due to the neural network architectures and feature vectors chosen for these approaches, the length of the predicted utterance has to be fixed to that of the input utterance, which limits the flexibility in mimicking the speaking rates and rhythmic patterns for the target speaker. On the other hand, sequence-to-sequence learning model was used to remove the above length constraint, but parallel training data are needed. In this paper, we propose an approach utilizing sequence-to-sequence model trained with unsupervised Cycle-GAN to perform the transformation between the phoneme posteriorgram sequences for different speakers. In this way, the length constraint mentioned above is removed to offer rhythm-flexible voice conversion without requiring parallel data. Preliminary evaluation on two datasets showed very encouraging results.Comment: 8 pages, 6 figures, Submitted to SLT 201

Young women's perceptions of replaceable upper shoes before and after the upper interchange

This study tries to investigate the visual perception of casual and formal leather shoe uppers, by conducting semantic differential evaluations. Twelve upper design renderings were generated based on six ideations with casual uppers converted into formal leather uppers. Based on a seven-point Likert scale, twelve renderings were evaluated using fifteen Kansei adjective pairs and young women's willingness to purchase. Factor analyses were performed to analyze the differences and factors between casual and formal leather uppers. In the factor analysis of upper styles, five factors were identified for casual uppers: evaluation, attention, fashion, protection, and temperament; and five factors for formal leather uppers: attention, formality, fashion, weight, and protection. Whether a young woman is looking for formal leather uppers or casual shoe uppers, fashion plays a crucial role in her decision to purchase shoes

Nondestructive Measurement Material Characterization of Thermal Sprayed Nickel Aluminum Coatings by using Laser Ultrasound Technique

AbstractThis research focused on characterization of mechanical properties in Nickel-Aluminum coating with different thermal technique and processing parameters at high temperature environment up to 295°C. With the laser ultrasound technique (LUT), guided acoustic waves are generated to propagate on the Ni-Al sprayed coatings. By measuring dispersive phase velocity followed by SCE-UA inversion algorithm. The Young's modulus of coatings which fabricated by HVOF technique is higher than APS technique. This technique is potentially useful to probe the material characterization at high temperature environment in a remote and non-destructive way

Two-Axis Solar Heat Collection Tracker System for Solar Thermal Applications

An experimental study was performed to investigate the effect of using a continuous operation two-axes tracking on the solar heat energy collected. This heat-collection sun tracking which LDR (light dependent resistor) sensors installed on the Fersnel lens was used to control the tracking path of the sun with programming method of control with a closed loop system. The control hardware was connected to a computer through Zigbee wireless module and it also can monitor the whole tracking process information on a computer screen. An experimental study was performed to investigate the effect of using two-axes tracking on the solar heat energy collected. The results indicate that sun tracking systems are being increasingly employed to enhance the efficiency of heat collection by polar-axis tracking of the sun. Besides, the heating power was also measured by designed power measurement module at the different focal length of Fresnel lens, and the design of shadow mask of LDR sensors is an important factor for solar photothermal applications. Moreover, the results also indicated that the best time to obtain the largest solar irradiation power is during 11:00 –13:00  in Taiwan

Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation.

PKM2 is a key metabolic enzyme central to glucose metabolism and energy expenditure. Multiple stimuli regulate PKM2's activity through allosteric modulation and post-translational modifications. Furthermore, PKM2 can partner with KDM8, an oncogenic demethylase and enter the nucleus to serve as a HIF1α co-activator. Yet, the mechanistic basis of the exon-10 region in allosteric regulation and nuclear translocation remains unclear. Here, we determined the crystal structures and kinetic coupling constants of exon-10 tumor-related mutants (H391Y and R399E), showing altered structural plasticity and reduced allostery. Immunoprecipitation analysis revealed increased interaction with KDM8 for H391Y, R399E, and G415R. We also found a higher degree of HIF1α-mediated transactivation activity, particularly in the presence of KDM8. Furthermore, overexpression of PKM2 mutants significantly elevated cell growth and migration. Together, PKM2 exon-10 mutations lead to structure-allostery alterations and increased nuclear functions mediated by KDM8 in breast cancer cells. Targeting the PKM2-KDM8 complex may provide a potential therapeutic intervention

Nonlinear photoacoustic microscopy via a loss modulation technique: from detection to imaging

In order to achieve high-resolution deep-tissue imaging, multi-photon fluorescence microscopy and photoacoustic tomography had been proposed in the past two decades. However, combining the advantages of these two imaging systems to achieve optical-spatial resolution with an ultrasonic-penetration depth is still a field with challenges. In this paper, we investigate the detection of the two-photon photoacoustic ultrasound, and first demonstrate background-free two-photon photoacoustic imaging in a phantom sample. To generate the background-free two-photon photoacoustic signals, we used a high-repetition rate femtosecond laser to induce narrowband excitation. Combining a loss modulation technique, we successfully created a beating on the light intensity, which not only provides pure sinusoidal modulation, but also ensures the spectrum sensitivity and frequency selectivity. By using the lock-in detection, the power dependency experiment validates our methodology to frequency-select the source of the nonlinearity. This ensures our capability of measuring the background-free two-photon photoacoustic waves by detecting the 2nd order beating signal directly. Furthermore, by mixing the nanoparticles and fluorescence dyes as contrast agents, the two-photon photoacoustic signal was found to be enhanced and detected. In the end, we demonstrate subsurface two-photon photoacoustic bio-imaging based on the optical scanning mechanism inside phantom samples