580 research outputs found
Modulation of Ca2+-dependent anion secretion by protein kinase C in normal and cystic fibrosis pancreatic duct cells
AbstractThe study investigated the role of protein kinase C (PKC) in the modulation of agonist-induced Ca2+-dependent anion secretion by pancreatic duct cells. The short-circuit current (ISC) technique was used to examine the effect of PKC activation and inhibition on subsequent ATP, angiotensin II and ionomycin-activated anion secretion by normal (CAPAN-1) and cystic fibrosis (CFPAC-1) pancreatic duct cells. The ISC responses induced by the Ca2+-mobilizing agents, which had been previously shown to be attributed to anion secretion, were enhanced in both CAPAN-1 and CFPAC-1 cells by PKC inhibitors, staurosporine, calphostin C or chelerythrine. On the contrary, a PKC activator, phorbol 12-myristate 13-acetate (PMA), was found to suppress the agonist-induced ISC in CFPAC-1 cells and the ionomycin-induced ISC in CAPAN-1 cells. An inactive form of PMA, 4αd-phorbol 12,13-didecanote (4αD), was found to exert insignificant effect on the agonist-induced ISC, indicating a specific effect of PMA. Our data suggest a role of PKC in modulating agonist-induced Ca2+-dependent anion secretion by pancreatic duct cells. Therapeutic strategy to augment Ca2+-activated anion secretion by cystic fibrosis pancreatic duct cells may be achieved by inhibition or down-regulation of PKC
Properties of Al-doped ZnS films grown by chemical bath deposition
Zinc sulphide (ZnS) buffer layers are a cadmium free, wider energy band gap, alternative to the cadmium sulphide(CdS) buffer layers commonly used in copper indium gallium diselenide (CuInGaSe2)-based solar cells. However extrinsic doping of the ZnS is important to lower the resistivity of the layers and to improve flexibility of device design. In this work, Al-doped ZnS nanocrystalline films have been produced on glass substrates using a chemical bath deposition (CBD) method. The Al- concentration was varied from 0 at. % to 10 at. %, keeping other deposition parameters constant. The elemental composition of a typical sample with 6 at. % âAlâ in ZnS was Zn=44.9 at. %, S=49.8 at. % and Al=5.3 at.%. The X-ray diffraction data taken on these samples showed a broad peak corresponding to the (111) plane of ZnS while the crystallite size varied in the range, 8 â 15 nm, depending on the concentration of Al in the layers. The films with a Al-doping content of 6 at. % had an optical transmittance of 75 % in the visible range and the energy band gap evaluated from the data was 3.66 eV. The films n-type electrical conductivities and the electrical resistivity varied in the range, 107-103 Ωcm, it decreasing with an increase of the Al-concentration in the solution
Vacuum polarization calculations for hydrogenlike and alkalilike ions
Complete vacuum polarization calculations incorporating finite nuclear size
are presented for hydrogenic ions with principal quantum numbers n=1-5.
Lithiumlike, sodiumlike, and copperlike ions are also treated starting with
Kohn-Sham potentials, and including first-order screening corrections. In both
cases dominant Uehling terms are calculated with high accuracy, and smaller
Wichmann- Kroll terms are obtained using numerical electron Green's functions.Comment: 23 pages, 1 figur
Spectrum of the Vortex Bound States of the Dirac and Schrodinger Hamiltonian in the presence of Superconducting Gaps
We investigate the vortex bound states both Schrodinger and Dirac Hamiltonian
with the s-wave superconducting pairing gap by solving the mean-field
Bogoliubov-de-Gennes equations. The exact vortex bound states spectrum is
numerically determined by the integration method, and also accompanied by the
quasi-classical analysis. It is found that the bound state energies is
proportional to the vortex angular momentum when the chemical potential is
large enough. By applying the external magnetic field, the vortex bound state
energies of the Dirac Hamiltonian are almost unchanged; whereas the energy
shift of the Schrodinger Hamiltonian is proportional to the magnetic field.
These qualitative differences may serve as an indirect evidence of the
existence of Majorana fermions in which the zero mode exists in the case of the
Dirac Hamiltonian only.Comment: 8 pages, 9 figure
Finite nuclear size and Lamb shift of p-wave atomic states
We consider corrections to the Lamb shift of p-wave atomic states due to the
finite nuclear size (FNS). In other words, these are radiative corrections to
the atomic isotop shift related to FNS. It is shown that the structure of the
corrections is qualitatively different from that for s-wave states. The
perturbation theory expansion for the relative correction for a -state
starts from -term, while for -states it starts
from term. Here is the fine structure constant and is
the nuclear charge. In the present work we calculate the -terms for
-states, the result for -state reads
. Even more interesting are
-states. In this case the ``correction'' is by several orders of
magnitude larger than the ``leading'' FNS shift.Comment: 4 pages, 2 figure
Mining State-Based Models from Proof Corpora
Interactive theorem provers have been used extensively to reason about
various software/hardware systems and mathematical theorems. The key challenge
when using an interactive prover is finding a suitable sequence of proof steps
that will lead to a successful proof requires a significant amount of human
intervention. This paper presents an automated technique that takes as input
examples of successful proofs and infers an Extended Finite State Machine as
output. This can in turn be used to generate proofs of new conjectures. Our
preliminary experiments show that the inferred models are generally accurate
(contain few false-positive sequences) and that representing existing proofs in
such a way can be very useful when guiding new ones.Comment: To Appear at Conferences on Intelligent Computer Mathematics 201
Radiative Corrections to One-Photon Decays of Hydrogenic Ions
Radiative corrections to the decay rate of n=2 states of hydrogenic ions are
calculated. The transitions considered are the M1 decay of the 2s state to the
ground state and the E1(M2) decays of the and states to
the ground state. The radiative corrections start in order , but the method used sums all orders of . The leading
correction for the E1 decays is calculated and compared
with the exact result. The extension of the calculational method to parity
nonconserving transitions in neutral atoms is discussed.Comment: 22 pages, 2 figure
Finite nuclear size effect on Lamb shift of s1/2, p1/2, and p3/2 atomic states
We consider one-loop self-energy and vacuum polarization radiative
corrections to the shift of atomic energy level due to finite nuclear size.
Analytic expressions for vacuum polarization corrections are derived. For the
self-energy of p1/2 and p3/2 states in addition to already known terms we
derive next-to-leading nonlogarithmic Z\alpha-terms. Together with
contributions obtained earlier the terms derived in the present work give
explicit analytic expressions for s1/2 and p1/2 corrections which agree with
results of previous numerical calculations up to Z=100 (Z is the nuclear charge
number). We also show that the finite nuclear size radiative correction for a
p3/2 state is not small compared to the similar correction for a p1/2 state at
least for small Z.Comment: 12 pages, 7 figure
Third-order relativistic many-body calculations of energies and lifetimes of levels along the silver isoelectronic sequence
Energies of 5l_j (l= s, p, d, f, g) and 4f_j states in neutral Ag and Ag-like
ions with nuclear charges Z = 48 - 100 are calculated using relativistic
many-body perturbation theory. Reduced matrix elements, oscillator strengths,
transition rates and lifetimes are calculated for the 17 possible 5l_j-5l'_{j'}
and 4f_j-5l_{j'} electric-dipole transitions. Third-order corrections to
energies and dipole matrix elements are included for neutral Ag and for ions
with Z60. Comparisons are made
with available experimental data for transition energies and lifetimes.
Correlation energies and transition rates are shown graphically as functions of
nuclear charge Z for selected cases. These calculations provide a theoretical
benchmark for comparison with experiment and theory.Comment: 8 page
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