Linear Displacement and Straightness Measurement by Fabry-Perot Interferometer Integrated with an Optoelectronic Module

This research develops a three degrees of freedom (DOF) measurement system by integrating Fabry-Perot interferometer and photoelectronic inspection module to determine linear displacement, horizontal and vertical straightness geometric error parameters simultaneously. The interferometer and the photoelectronic inspection module in a three DOF measurement system share the same light source, and the two structures are used to measure linear displacement and straightness errors. The experimental results are utilized to calculate the relevant error parameters according to ISO standards and numerical analysis. They show that after the machine error compensation, the positioning deviation of the system is reduced from 55 μm to 19 μm, corresponding to the reduction of 65%. The accuracy is promoted from 65 μm to 31 μm, about the improvement of 52%. The horizontal and vertical straightness errors of the machine are 4.30 μm and 5.71 μm respectively

Increase of ATP-sensitive potassium (KATP) channels in the heart of type-1 diabetic rats

<p>Abstract</p> <p>Background</p> <p>An impairment of cardiovascular function in streptozotocin (STZ)-diabetic rats has been mentioned within 5 days-to-3 months of induction. ATP-sensitive potassium (K_ATP) channels are expressed on cardiac sarcolemmal membranes. It is highly responsive to metabolic fluctuations and can have effects on cardiac contractility. The present study attempted to clarify the changes of cardiac K_ATPchannels in diabetic disorders.</p> <p>Methods</p> <p>Streptozotocin-induced diabetic rats and neonatal rat cardiomyocytes treated with a high concentration of glucose (a D-glucose concentration of 30 mM was used and cells were cultured for 24 hr) were used to examine the effect of hyperglycemia on cardiac function and the expression of K_ATPchannels. K_ATPchannels expression was found to be linked to cardiac tonic dysfunction, and we evaluated the expression levels of K_ATPchannels by Western blot and Northern blot analysis.</p> <p>Results</p> <p>The result shows diazoxide produced a marked reduction of heart rate in control group. Furthermore, the methods of Northern blotting and Western blotting were employed to identify the gene expression of K_ATPchannel. Two subunits of cardiac K_ATPchannel (SUR2A and kir 6.2) were purchased as indicators and showed significantly decreased in both diabetic rats and high glucose treated rat cardiac myocytes. Correction of hyperglycemia by insulin or phlorizin restored the gene expression of cardiac K_ATPin these diabetic rats.</p> <p>Conclusions</p> <p>Both mRNA and protein expression of cardiac K_ATPchannels are decreased in diabetic rats induced by STZ for 8 weeks. This phenomenon leads to result in desensitization of some K_ATPchannel drugs.</p