4,876 research outputs found
Deepen the understanding for school bully-victims : the reasons for bully-victims' role formations, role transitions, and role terminations
C
Canonical interpretation of and in the family
Inspired by the new resonance , we calculate the masses and
two-body OZI-allowed strong decays of the higher vector bottomonium sates
within both screened and linear potential models. We discuss the possibilities
of and as mixed states via the mixing. Our
results suggest that and might be explained as
mixed states between - and -wave vector states. The
and resonances may correspond to the mixed states
dominated by the - and -wave components, respectively. The mass and the
strong decay behaviors of the resonance are consistent with
the assignment of the state in the potential models.Comment: 9 pages, 4 figures. More discussions are adde
Mees Line of Nails, Osler Nodes, Janeway Lesions as evidence of disseminated intravascular coagulation
Podeu consultar la versió en català a: http://hdl.handle.net/11703/8944
New primers for methylation-specific polymerase chain reaction enhance specificity of detecting STAT1 methylation
AbstractObjectiveSignal transducer and activator of transcription (STAT)1 is a key tumor suppressor, which is always methylated in a variety of human cancers. However, nonspecific primers for the detection of specific promoter hypermethylation of STAT1 gene can lead to false-positive or false-negative results for gene methylation.Materials and MethodsWe designed new primers for the detection of STAT1 methylation and compared the sensitivities and specificities of these new primers with prior published primers by methylation-specific polymerase chain reaction (PCR) from ovarian clear cell carcinomas. The mRNA expression levels of STAT1 in these cancerous tissues were also evaluated by reverse-transcriptase PCR and correlated with the results of promoter methylation of STAT1 gene.ResultsNine (39%) of the 23 samples detected by the new primers and 13 samples (56%) detected by prior published primers showed STAT1 methylation. A direct DNA sequencing test revealed that four of the 13 samples (30.8%) showed false positivity for STAT1 methylation using the prior published primers. In contrast, none of the nine samples was false-positive for the detection of STAT1 methylation using the new primers. The new primers for the detection of STAT1 methylation showed 100% specificity and 100% sensitivity without false positivity.ConclusionSpecific primers for methylation-specific PCR are mandatory for the accurate detection of STAT1 gene methylation. Besides, specific primers can generate correct interpretation of STAT1 gene methylation, and its correlation with the clinicopathological characteristics and outcome of cancer patients
Weighted Shift Matrices: Unitary Equivalence, Reducibility and Numerical Ranges
An -by- () weighted shift matrix is one of the form
[{array}{cccc}0 & a_1 & & & 0 & \ddots & & & \ddots & a_{n-1} a_n & & &
0{array}], where the 's, called the weights of , are complex numbers.
Assume that all 's are nonzero and is an -by- weighted shift
matrix with weights . We show that is unitarily equivalent to
if and only if and, for some fixed , , () for all . Next, we show that
is reducible if and only if has periodic weights, that is, for some
fixed , , is divisible by , and
for all . Finally, we prove that and
have the same numerical range if and only if and
for all , where 's are the circularly symmetric functions.Comment: 27 page
Maternal Baicalin Treatment Increases Fetal Lung Surfactant Phospholipids in Rats
Baicalin is a flavonoid compound purified from the medicinal plant Scutellaria baicalensis Georgi and has been reported to stimulate surfactant protein (SP)-A gene expression in human lung epithelial cell lines (H441). The aims of this study were to determine whether maternal baicalin treatment could increase lung surfactant production and induce lung maturation in fetal rats. This study was performed with timed pregnant Sprague-Dawley rats. One-day baicalin group mothers were injected intraperitoneally with baicalin (5 mg/kg/day) on Day 18 of gestation. Two-day baicalin group mothers were injected intraperitoneally with baicalin (5 mg/kg/day) on Days 17 and 18 of gestation. Control group mothers were injected with vehicle alone on Day 18 of gestation. On Day 19 of gestation, fetuses were delivered by cesarean section. Maternal treatment with 2-day baicalin significantly increased saturated phospholipid when compared with control group and total phospholipid in fetal lung tissue when compared with control and 1-day baicalin groups. Antenatal treatment with 2-day baicalin significantly increased maternal growth hormone when compared with control group. Fetal lung SP-A mRNA expression and maternal serum corticosterone levels were comparable among the three experimental groups. Maternal baicalin treatment increases pulmonary surfactant phospholipids of fetal rat lungs and the improvement was associated with increased maternal serum growth hormone. These results suggest that antenatal baicalin treatment might accelerate fetal rat lung maturation
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