3,856 research outputs found

    Structure characterizations and protein resistance of chitosan membranes selectively crosslinked by poly(ethylene glycol) dimethacrylate

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    [[abstract]]Chitosan (CS) is a fragile material with a high modulus of elasticity. Improving its flexibility as well as membrane permeability are the key aspects that need to be addressed for using CS as a biomaterial. Poly(ethylene glycol) (PEG) has several unique properties such as protein resistance, low toxicity, immunogenicity, and good solubility in both water and organic solvents. In this study, a vinyl compound was grafted to the C-6 position of CS by protection-grafting-deprotection. The vinyl CS was then crosslinked with PEG dimethacrylate (PEGDMA) selectively at its C-6 position to form CS-g-PEG copolymer membranes. Analyses from spectra of Fourier-transform infrared and nuclear magnetic resonance confirmed the chemical structure of the crosslinking CS-g-PEG copolymer membranes. Thermal and mechanical properties of the prepared CS-g-PEG membranes were measured and well-correlated to their structures. The incorporation of PEGDMA into the CS increased the material’s flexibility and thermal resistance. Finally, the CS-g-PEG membranes were found to have good protein resistance and blood compatibility; therefore, it has potential application as the biomedical material especially for hemodialysis.[[notice]]補正完畢[[incitationindex]]SCI[[booktype]]電子

    Supervised Collective Classification for Crowdsourcing

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    Crowdsourcing utilizes the wisdom of crowds for collective classification via information (e.g., labels of an item) provided by labelers. Current crowdsourcing algorithms are mainly unsupervised methods that are unaware of the quality of crowdsourced data. In this paper, we propose a supervised collective classification algorithm that aims to identify reliable labelers from the training data (e.g., items with known labels). The reliability (i.e., weighting factor) of each labeler is determined via a saddle point algorithm. The results on several crowdsourced data show that supervised methods can achieve better classification accuracy than unsupervised methods, and our proposed method outperforms other algorithms.Comment: to appear in IEEE Global Communications Conference (GLOBECOM) Workshop on Networking and Collaboration Issues for the Internet of Everythin

    Probabilistic Risk Assessment of Reservoir Operation

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    Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchive

    Small B cell lymphocytic lymphoma presenting as obstructive sleep apnea

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    BACKGROUND: Most lymphomas that involve the tonsil are large B cell lymphomas. Large B-cell lymphoma is a high grade malignancy which progresses rapidly. Tonsillar lymphoma usually presents as either a unilaterally enlarged palatine tonsil or as an ulcerative and fungating lesion over the tonsillar area. Small lymphocytic lymphomas (SLL) of the Waldeyer's ring are uncommon. CASE PRESENTATION: We report a 41-year-old male who presented with a ten-year history of snoring. Physical examination revealed smooth bilateral symmetrically enlarged tonsils without abnormal surface change or cervical lymphadenopathy. Palatal redundancy and a narrowed oropharyngeal airway were also noted. The respiratory disturbance index (RDI) was 66 per hour, and severe obstruction sleep apnea (OSA) was suspected. No B symptoms, sore throat, odynophagia or dysphagia was found. We performed uvulopalatopharyngoplasty (UPPP) and pathological examination revealed incidental small B-cell lymphocytic lymphoma (SLL). CONCLUSION: It is uncommon for lymphoma to initially present as OSA. SLL is an indolent malignancy and is not easy to detect in the early stage. We conclude that SLL may be a contributing factor of OSA in the present case

    Vibration characteristics and modal analysis of a grinding machine

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    The machine industry has undergone several developments in the past years, and reducing the cost and time required for machine designing is important. In this study, the vibration characteristics of a precision grinding machine were obtained through experimental modal analysis and finite element analysis. The experimental modal analysis employed single point excitation, and the equipment used to determine the frequency response of the grinding machine comprised a hammer, an accelerometer, and a spectrum analyzer. In addition, the resonance frequency, damping factor, and modal shape of the grinding machine were determined. The natural frequency, modal shape, and interface stiffness were determined through finite element analysis. Finally, the theoretical model and the experimental modal analysis models were compared, and get closer to the actual situation of a model to conduct several times analysis. Thus, this paper presents a reliable and convenient method to study the characteristics of machine tools; this method can reduce unnecessary costs and find structural weaknesses in machine designs for improvement

    Bacteremic pneumonia caused by extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae: Appropriateness of empirical treatment matters

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    BackgroundClinical information about bacteremic pneumonia caused by extended-spectrum beta-lactamase (ESBL)-producing organism is limited.MethodsA retrospective study was conducted at two medical centers in Taiwan. From May 2002 to August 2010, clinical information and outcome of adults with bacteremic pneumonia caused by ESBL-producing Escherichia coli and Klebsiella pneumoniae were analyzed. The primary outcome is the 30-day mortality.ResultsA total of 111 patients with bacteremic pneumonia caused by E. coli (37 patients, 33.3%) and K. pneumoniae (74, 66.7%) were identified. Their mean age was 69.2 years and 51.4% were male patients. Fifty-seven (51.3%) episodes were classified as hospital-acquired infections, 19 (17.1%) as health-care-associated infections, and four (3.6%) as community-acquired infections. Fifty-one (45.9%) patients received appropriate empiric antimicrobial therapy. The 30-day mortality rate was 40.5% (45 patients). In the multivariate analysis, several independent risk factors, including rapidly fatal underlying disease [odds ratio (OR), 5.75; 95% confidence interval (CI), 1.54–21.48; p = 0.009], severe sepsis (OR, 4.84; 95% CI, 1.55–15.14; p = 0.007), critical illness (OR, 4.28; 95% CI, 1.35–13.57; p = 0.013), and receipt of appropriate empirical therapy (OR, 0.19; 95% CI, 0.07–0.55; p = 0.002), were associated with 30-day mortality. The survival analysis consistently found that individuals with appropriate empiric therapy had a higher survival rate (log-rank test, p < 0.001).ConclusionESBL-producing bacteremic pneumonia, especially health-care-associated infections, often occurred in adults with comorbidities. Appropriate empirical therapy was associated with a favorable outcome
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