Definitions for the original and modified CTP classifications.

<p>Modified CTP class 0: Fulfill all criteria of albumin ≧4.0 g/dL, bilirubin ≦0.8 mg/dL, prothromin time prolongation <0 seconds, no ascites and no encephalopathy.</p><p>Modified CTP class A: total scores of 5–6 and not fulfilling criteria for class 0; class B: total scores of 7–9; class C: total scores of 10–15.</p><p><b>Abbreviations</b>: CTP, Child-Turcotte-Pugh.</p

Definitions for the original and modified CTP classifications.

<p>Modified CTP class 0: Fulfill all criteria of albumin ≧4.0 g/dL, bilirubin ≦0.8 mg/dL, prothromin time prolongation <0 seconds, no ascites and no encephalopathy.</p><p>Modified CTP class A: total scores of 5–6 and not fulfilling criteria for class 0; class B: total scores of 7–9; class C: total scores of 10–15.</p><p><b>Abbreviations</b>: CTP, Child-Turcotte-Pugh.</p

The distribution of HCC patients after modification of the CTP classifications.

<p><b>Abbreviations</b>: CTP, Child-Turcotte-Pugh; HCC, hepatocellular carcinoma; No., number.</p

Univariate and multivariate Cox regression survival analysis in HCC patients.

<p><b>Abbreviations</b>: HCC, hepatocellular carcinoma; HR, hazard ratio; CI, confidence interval; HBsAg, hepatitis B surface antigen; AFP, α-fetoprotein; TTV, total tumor volume; ECOG, Eastern Cooperative Oncology Group; CTP, Child-Turcotte-Pugh.</p

Comparison of survival between stages in the original and modified models BCLC, CLIP and TIS with the lowest AIC score.

<p>Patients with a more advanced stage were associated with a worse long-term survival in the original (panel A) and modified model B (panel B) BCLC systems, the original (panel C) and modified model A (panel D) CLIP systems, the original (panel E) and modified model A (panel F) TIS systems (all p<0.001). Pairwise comparison of survival differences between all stages in the modified BCLC, CLIP and TIS staging systems showed significant differences between each stage (all p<0.05), except for patients with modified BCLC stage 0 and A (p = 0.08).</p

Baseline demographics of all HCC patients and HCC patients with modified CTP class 0, A, B and C.

<p><b>Abbreviations</b>: HCC, hepatocellular carcinoma; CTP, Child-Turcotte-Pugh; SD, standard deviation; HBV, hepatitis B virus; HCV, hepatitis C virus; BUN, blood urea nitrogen; INR, international normalized ratio; PT, prothrombin time; ALT, alanine aminotransferase; AFP, α-fetoprotein; IQR, interquartile range; MELD, model for end-stage liver disease; No., number; TTV, total tumor volume; TACE, transcatheter arterial chemoembolization; BCLC, Barcelona Clinic Liver Cancer; CLIP, Cancer of the Liver Italian Program; TIS, Taipei Integrated Scoring.</p

The proposed criteria for original and modified models of the CLIP and TIS staging systems.

<p><b>Abbreviations</b>: CTP, Child-Turcotte-Pugh; CLIP, Cancer of the Liver Italian Program; TIS, Taipei Integrated Scoring.</p

Comparison of the prognostic ability among 4 BCLC-, 4 CLIP- and 4 TIS-based staging systems.

<p><b>Abbreviations</b>: BCLC, Barcelona Clinic Liver Cancer; CLIP, Cancer of the Liver Italian Program; TIS, Taipei Integrated Scoring.</p

Comparison of survival distributions between patients of different CTP classifications.

<p>Patients with the new CTP class 0 were associated with a better long-term survival (panel B; p<0.001). Pairwise comparison between each CTP and modified CTP classes showed significant survival differences (panel A p<0.001).</p