1,167 research outputs found
A side-by-side comparison of Daya Bay antineutrino detectors
The Daya Bay Reactor Neutrino Experiment is designed to determine precisely
the neutrino mixing angle with a sensitivity better than 0.01 in
the parameter sin at the 90% confidence level. To achieve this
goal, the collaboration will build eight functionally identical antineutrino
detectors. The first two detectors have been constructed, installed and
commissioned in Experimental Hall 1, with steady data-taking beginning
September 23, 2011. A comparison of the data collected over the subsequent
three months indicates that the detectors are functionally identical, and that
detector-related systematic uncertainties exceed requirements.Comment: 24 pages, 36 figure
Observation of electron-antineutrino disappearance at Daya Bay
The Daya Bay Reactor Neutrino Experiment has measured a non-zero value for
the neutrino mixing angle with a significance of 5.2 standard
deviations. Antineutrinos from six 2.9 GW reactors were detected in
six antineutrino detectors deployed in two near (flux-weighted baseline 470 m
and 576 m) and one far (1648 m) underground experimental halls. With a 43,000
ton-GW_{\rm th}-day livetime exposure in 55 days, 10416 (80376) electron
antineutrino candidates were detected at the far hall (near halls). The ratio
of the observed to expected number of antineutrinos at the far hall is
. A rate-only analysis
finds in a
three-neutrino framework.Comment: 5 figures. Version to appear in Phys. Rev. Let
Constraints on Astro-unparticle Physics from SN 1987A
SN 1987A observations have been used to place constraints on the interactions
between standard model particles and unparticles. In this study we calculate
the energy loss from the supernovae core through scalar, pseudo scalar, vector,
pseudo vector unparticle emission from nuclear bremsstrahlung for degenerate
nuclear matter interacting through one pion exchange. In order to examine the
constraints on we considered the emission of scalar, pseudo
scalar, vector, pseudo vector and tensor through the pair annihilation process
. In addition we have re-examined other pair
annihilation processes. The most stringent bounds on the dimensionless coupling
constants for and are obtained from
nuclear bremsstrahlung process for the pseudo scalar and pseudo-vector
couplings and for
tensor interaction, the best limit on dimensionless coupling is obtained from
and we get .Comment: 12 pages, 2 postscript figure
Constraints from Solar and Reactor Neutrinos on Unparticle Long-Range Forces
We have investigated the impact of long-range forces induced by unparticle
operators of scalar, vector and tensor nature coupled to fermions in the
interpretation of solar neutrinos and KamLAND data. If the unparticle couplings
to the neutrinos are mildly non-universal, such long-range forces will not
factorize out in the neutrino flavour evolution. As a consequence large
deviations from the observed standard matter-induced oscillation pattern for
solar neutrinos would be generated. In this case, severe limits can be set on
the infrared fix point scale, Lambda_u, and the new physics scale, M, as a
function of the ultraviolet (d_UV) and anomalous (d) dimension of the
unparticle operator. For a scalar unparticle, for instance, assuming the
non-universality of the lepton couplings to unparticles to be of the order of a
few per mil we find that, for d_UV=3 and d=1.1, M is constrained to be M >
O(10^9) TeV (M > O(10^10) TeV) if Lambda_u= 1 TeV (10 TeV). For given values of
Lambda_u and d, the corresponding bounds on M for vector [tensor] unparticles
are approximately 100 [3/Sqrt(Lambda_u/TeV)] times those for the scalar case.
Conversely, these results can be translated into severe constraints on
universality violation of the fermion couplings to unparticle operators with
scales which can be accessible at future colliders.Comment: 13 pages, 3 figures. Minor changes due to precision in numerical
factors and correction in figure labels. References added. Conclusions remain
unchange
Spectral Measurement of Electron Antineutrino Oscillation Amplitude and Frequency at Daya Bay
ER Stress Negatively Modulates the Expression of the miR-199a/214 Cluster to Regulates Tumor Survival and Progression in Human Hepatocellular Cancer
Background: Recent studies have emphasized causative links between microRNAs (miRNAs) deregulation and tumor development. In hepatocellular carcinoma (HCC), more and more miRNAs were identified as diagnostic and prognostic cancer biomarkers, as well as additional therapeutic tools. This study aimed to investigate the functional significance and regulatory mechanism of the miR-199a2/214 cluster in HCC progression. Methods and Findings: In this study, we showed that miR-214, as well as miR-199a-3p and miR-199a-5p levels were significantly reduced in the majority of examined 23 HCC tissues and HepG2 and SMMC-7721 cell lines, compared with their nontumor counterparts. To further explore the role of miR-214 in hepatocarcinogenesis, we disclosed that the ER stressinduced pro-survival factor XBP-1 is a target of miR-214 by using western blot assay and luciferase reporter assay. Reexpression of miR-214 in HCC cell lines (HepG2 and SMMC-7721) inhibited proliferation and induced apoptosis. Furthermore, ectopic expression of miR-214 dramatically suppressed the ability of HCC cells to form colonies in vitro and to develop tumors in a subcutaneous xenotransplantation model of the BALB/c athymic nude mice. Moreover, reintroduction of XBP-1s attenuated miR-214-mediated suppression of HCC cells proliferation, colony and tumor formation. To further understand the mechanism of the miR-199a/214 cluster down-expression in HCC, we found that thapsigargin (TG) and tunicamycin (TM) or hypoxia-induced unfolded protein response (UPR) suppresses the expression of the miR-199a/21
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