1,451 research outputs found
Identifying Boosted Objects with N-subjettiness
We introduce a new jet shape -- N-subjettiness -- designed to identify
boosted hadronically-decaying objects like electroweak bosons and top quarks.
Combined with a jet invariant mass cut, N-subjettiness is an effective
discriminating variable for tagging boosted objects and rejecting the
background of QCD jets with large invariant mass. In efficiency studies of
boosted W bosons and top quarks, we find tagging efficiencies of 30% are
achievable with fake rates of 1%. We also consider the discovery potential for
new heavy resonances that decay to pairs of boosted objects, and find
significant improvements are possible using N-subjettiness. In this way,
N-subjettiness combines the advantages of jet shapes with the discriminating
power seen in previous jet substructure algorithms.Comment: 26 pages, 26 figures, 2 tables; v2: references added; v3: discussion
of results extende
Biofilter aquaponic system for nutrients removal from fresh market wastewater
Aquaponics is a significant wastewater treatment system which refers to the combination of conventional aquaculture (raising aquatic organism) with hydroponics (cultivating plants in water) in a symbiotic environment. This system has a high ability in removing nutrients compared to conventional methods because it is a natural and environmentally friendly system (aquaponics). The current chapter aimed to review the possible application of aquaponics system to treat fresh market wastewater with the intention to highlight the mechanism of phytoremediation occurs in aquaponic system. The literature revealed that aquaponic system was able to remove nutrients in terms of nitrogen and phosphorus
PTHrP Induces Autocrine/Paracrine Proliferation of Bone Tumor Cells through Inhibition of Apoptosis
Giant Cell Tumor of Bone (GCT) is an aggressive skeletal tumor characterized by local bone destruction, high recurrence rates and metastatic potential. Previous work in our lab has shown that the neoplastic cell of GCT is a proliferating pre-osteoblastic stromal cell in which the transcription factor Runx2 plays a role in regulating protein expression. One of the proteins expressed by these cells is parathryroid hormone-related protein (PTHrP). The objectives of this study were to determine the role played by PTHrP in GCT of bone with a focus on cell proliferation and apoptosis. Primary stromal cell cultures from 5 patients with GCT of bone and one lung metastsis were used for cell-based experiments. Control cell lines included a renal cell carcinoma (RCC) cell line and a human fetal osteoblast cell line. Cells were exposed to optimized concentrations of a PTHrP neutralizing antibody and were analyzed with the use of cell proliferation and apoptosis assays including mitochondrial dehydrogenase assays, crystal violet assays, APO-1 ELISAs, caspase activity assays, flow cytometry and immunofluorescent immunohistochemistry. Neutralization of PTHrP in the cell environment inhibited cell proliferation in a consistent manner and induced apoptosis in the GCT stromal cells, with the exception of those obtained from a lung metastasis. Cell cycle progression was not significantly affected by PTHrP neutralization. These findings indicate that PTHrP plays an autocrine/paracrine neoplastic role in GCT by allowing the proliferating stromal cells to evade apoptosis, possibly through non-traditional caspase-independent pathways. Thus PTHrP neutralizing immunotherapy is an intriguing potential therapeutic strategy for this tumor
Investigation of Thermal Diffusivity for Nano-Phase Composite Ceramics
In recent years, there has been increasing interest in nanostructured ceramic materials because of their advanced properties. The superplasticity; improved strength and toughness, higher densification rate and low sintering temperature are observed in these materials[1–4]. The sintering speed vsintering of ceramic is related to the grain size d by the expression of vsin ting ∝d-4 [2]. By adding the nano-particles of Al2O3 to conventional Al2O3, the strength, fracture toughness and thermal resistance of Al2O3 ceramic can increase[5]. Up to now, only a few researchers[6,7] have concerned about the specific heat and thermal expansion of nano- ceramics, and no report about thermal diffusivity of nano-composite has been found in literature. However, characterizations of thermal diffusivity of nanocomposite ceramics are very important for designing and preparing this kind of new materials.</p
What's new in the management of chronic lymphocytic leukemia? 2008 ASH Review (New York Medical College, January 31, 2009)
Promising treatment outcomes of intensity-modulated radiation therapy for nasopharyngeal carcinoma patients with N0 disease according to the seventh edition of the AJCC staging system
Revisiting Date and Party Hubs: Novel Approaches to Role Assignment in Protein Interaction Networks
The idea of 'date' and 'party' hubs has been influential in the study of
protein-protein interaction networks. Date hubs display low co-expression with
their partners, whilst party hubs have high co-expression. It was proposed that
party hubs are local coordinators whereas date hubs are global connectors. Here
we show that the reported importance of date hubs to network connectivity can
in fact be attributed to a tiny subset of them. Crucially, these few, extremely
central, hubs do not display particularly low expression correlation,
undermining the idea of a link between this quantity and hub function. The
date/party distinction was originally motivated by an approximately bimodal
distribution of hub co-expression; we show that this feature is not always
robust to methodological changes. Additionally, topological properties of hubs
do not in general correlate with co-expression. Thus, we suggest that a
date/party dichotomy is not meaningful and it might be more useful to conceive
of roles for protein-protein interactions rather than individual proteins. We
find significant correlations between interaction centrality and the functional
similarity of the interacting proteins.Comment: 27 pages, 5 main figures, 4 supplementary figure
Factorization and resummation of s-channel single top quark production
In this paper we study the factorization and resummation of s-channel single
top quark production in the Standard Model at both the Tevatron and the LHC. We
show that the production cross section in the threshold limit can be factorized
into a convolution of hard function, soft function and jet function via
soft-collinear-effective-theory (SCET), and resummation can be performed using
renormalization group equation in the momentum space resummation formalism. We
find that in general, the resummation effects enhance the Next-to-Leading-Order
(NLO) cross sections by about at both the Tevatron and the LHC, and
significantly reduce the factorization scale dependence of the total cross
section at the Tevatron, while at the LHC we find that the factorization scale
dependence has not been improved, compared with the NLO results.Comment: 29 pages, 7 figures; version published in JHE
Quantum Measurement Theory in Gravitational-Wave Detectors
The fast progress in improving the sensitivity of the gravitational-wave (GW)
detectors, we all have witnessed in the recent years, has propelled the
scientific community to the point, when quantum behaviour of such immense
measurement devices as kilometer-long interferometers starts to matter. The
time, when their sensitivity will be mainly limited by the quantum noise of
light is round the corner, and finding the ways to reduce it will become a
necessity. Therefore, the primary goal we pursued in this review was to
familiarize a broad spectrum of readers with the theory of quantum measurements
in the very form it finds application in the area of gravitational-wave
detection. We focus on how quantum noise arises in gravitational-wave
interferometers and what limitations it imposes on the achievable sensitivity.
We start from the very basic concepts and gradually advance to the general
linear quantum measurement theory and its application to the calculation of
quantum noise in the contemporary and planned interferometric detectors of
gravitational radiation of the first and second generation. Special attention
is paid to the concept of Standard Quantum Limit and the methods of its
surmounting.Comment: 147 pages, 46 figures, 1 table. Published in Living Reviews in
Relativit
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