942 research outputs found
Fabrication and research of 3D complex scaffolds for bone tissue engineering based on extrusion–deposition technique
Fabrication of scaffold is the key for bone tissue engineering, which is commonly regarded as the most potential route for repairing bone defects. Previously, porous ceramic scaffolds were fabricated through a variety of traditional methods, like moulding and casting, but most of them cannot produce customised tissue-engineered scaffolds. Therefore, 3D printing methods are gaining more attention and are currently being explored and developed to make scaffolds with acceptable biocompatibility.
With the considerable development of bone tissue engineering, the bioactivity of scaffolds is becoming increasingly demanded, which leads to new methods and techniques to produce highly biomimetic bone scaffolds. In this study, a new fabrication process to optimise the structures of scaffolds was developed, and intensive researches were performed on the porous scaffolds to confirm their advantages in biological performance. Specifically, by combination of motor assisted extrusion deposition and gas-foaming (graphite as the porogen) technique, hierarchically porous scaffolds with improved microstructures, i.e. multi-scaled pores from nanometre to millimetre (nm-μm-mm), was successfully developed.
In this thesis, the optimal content of porogen for scaffolds was studied in terms of compressive strength and in-rod porosities. The most concerned physicochemical properties of scaffolds were carefully examined and the results revealed that such scaffolds exhibit excellent physicochemical properties owing to hierarchically porous structures. Due to additional in-rod micropores and increased specific surface area, along with better hydrophilicity, hierarchically porous scaffolds exerted complete superiority in biological activity, including promoting cellular proliferation of osteoblasts, adhesion and spreading status, as well as the ability to induce cellular differentiation
Towards Efficient Path Query on Social Network with Hybrid RDF Management
The scalability and exibility of Resource Description Framework(RDF) model
make it ideally suited for representing online social networks(OSN). One basic
operation in OSN is to find chains of relations,such as k-Hop friends. Property
path query in SPARQL can express this type of operation, but its implementation
suffers from performance problem considering the ever growing data size and
complexity of OSN.In this paper, we present a main memory/disk based hybrid RDF
data management framework for efficient property path query. In this hybrid
framework, we realize an efficient in-memory algebra operator for property path
query using graph traversal, and estimate the cost of this operator to
cooperate with existing cost-based optimization. Experiments on benchmark and
real dataset demonstrated that our approach can achieve a good tradeoff between
data load expense and online query performance
Production of trimethylaluminum (Me3Al) with counterfeit refrigerant chloromethane (R-40), reactivity of Me3Al with refrigerant oils and methods to deactivate Me3Al
Reactions between Al containing materials and counterfeit refrigerant chloromethane (R-40) were investigated under various conditions. The addition of Mg effected a reaction indicating that trimethylaluminum may have been produced in the reaction. A different study involving Al-foil, AlCl3 and chloromethane resulted in cracks detected on the Al-foil which reduced in weight by 19% and methane was detected. Studies conducted either at room temperature or at 80°C with two other genuine refrigerants, R-142b (1-chloro-1,1-difluoroethane) and R-133a (2-chloro-1,1,1-trifluoroethane) did not form organoaluminum compounds. Several commercially available refrigerant oils were subjected to Me3Al. Only polyester oil resulted in a decrease in the quantity of methane released upon final deactivation with alcohol. Various chemicals were added to Me3Al in order to find which ones would react and not produce methane. Phthalaldehyde was determined to be the most efficient reagent by deactivating approximately 50% of the methyl groups on Me3Al
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