Global Earth’s gravity field solution with GRACE orbit and range measurements using modified short arc approach

Traditionally, the Earth’s gravity field model is computed from GRACE orbit and range rate measurements, e.g., in a short arc approach where both the position and the velocity vectors are integrated from a force model. In this contribution, we use the GRACE orbit and range measurements to recover the Earth’s gravity field model, thus we only need to integrate the position vectors. We use the range differences between two adjacent epochs to eliminate the range ambiguities. Using GRACE Level-1B RL02 data released by Jet Propulsion laboratory, the gravity field model TJGRACE02O complete to degree and order 90 is developed from 7 years of reduced dynamic orbits covering the period 2004–2010, and the gravity field model TJGRACE02K complete to degree and order 120 is computed from 1 month of kinematic orbits and K-band range data of January. Comparing the degree geoid errors of our new models with recent gravity field models such as the CHAMP-only models EIGEN-CHAMP05S, AIUB-CHAMP03S, ULUX-CHAMP2013S and the GRACE-only models GGM05S, Tongji-GRACE01 as well as a monthly model from the ITG-GRACE2010 time series, and validating these models with GPS-leveling data sets in the USA, we can conclude that the TJGRACE02O model is more accurate than all the CHAMP-only models and TJGRACE02K is comparable in quality to the corresponding GRACE monthly model from ITG-GRACE2010.Department of Land Surveying and Geo-Informatic

Antidiabetic Effects of a Chinese Herbal Medicinal Compound Sangguayin Preparation via PI3K/Akt Signaling Pathway in db/db

Sangguayin (SGY), comprising four types of Chinese herbs, can be used as both food and medicine and has been clinically used to treat type 2 diabetes mellitus (T2DM) for a long time. Our previous study demonstrated the antidiabetic effect of SGY in experimental T2DM rats fed with a high-fat diet and treated with a low dose of streptozotocin. However, its mechanism of action is questionable. In this study, we refined the traditional SGY decoction and investigated its antidiabetic activity in db/db mice. We evaluated the possible molecular mechanism using skeletal muscle tissues. The results show that the treatment with SGY preparation resulted in a decrease in the blood glucose, glycated serum protein, and blood lipid levels and an improvement in the glucose tolerance as well as insulin resistance. In addition, SGY preparation remarkably upregulated the expression of insulin receptor, insulin receptor substrate-1, phosphoinositide 3 kinase (PI3K), protein kinase B (Akt), and glucose transporter type 4 (GLUT4). Thus, SGY preparation is an effective agent for the treatment of T2DM, and its molecular mechanism may be related to the regulation of PI3K/Akt signaling in the skeletal muscle