miRDB: An online database for prediction of functional microRNA targets

MicroRNAs (miRNAs) are small noncoding RNAs that act as master regulators in many biological processes. miRNAs function mainly by downregulating the expression of their gene targets. Thus, accurate prediction of miRNA targets is critical for characterization of miRNA functions. To this end, we have developed an online database, miRDB, for miRNA target prediction and functional annotations. Recently, we have performed major updates for miRDB. Specifically, by employing an improved algorithm for miRNA target prediction, we now present updated transcriptome-wide target prediction data in miRDB, including 3.5 million predicted targets regulated by 7000 miRNAs in five species. Further, we have implemented the new prediction algorithm into a web server, allowing custom target prediction with user-provided sequences. Another new database feature is the prediction of cell-specific miRNA targets. miRDB now hosts the expression profiles of over 1000 cell lines and presents target prediction data that are tailored for specific cell models. At last, a new web query interface has been added to miRDB for prediction of miRNA functions by integrative analysis of target prediction and Gene Ontology data. All data in miRDB are freely accessible at http://mirdb.org

Mitigating Motion Blur for Robust 3D Baseball Player Pose Modeling for Pitch Analysis

Using videos to analyze pitchers in baseball can play a vital role in strategizing and injury prevention. Computer vision-based pose analysis offers a time-efficient and cost-effective approach. However, the use of accessible broadcast videos, with a 30fps framerate, often results in partial body motion blur during fast actions, limiting the performance of existing pose keypoint estimation models. Previous works have primarily relied on fixed backgrounds, assuming minimal motion differences between frames, or utilized multiview data to address this problem. To this end, we propose a synthetic data augmentation pipeline to enhance the model's capability to deal with the pitcher's blurry actions. In addition, we leverage in-the-wild videos to make our model robust under different real-world conditions and camera positions. By carefully optimizing the augmentation parameters, we observed a notable reduction in the loss by 54.2% and 36.2% on the test dataset for 2D and 3D pose estimation respectively. By applying our approach to existing state-of-the-art pose estimators, we demonstrate an average improvement of 29.2%. The findings highlight the effectiveness of our method in mitigating the challenges posed by motion blur, thereby enhancing the overall quality of pose estimation.Comment: Accepted in the 6th International Workshop on Multimedia Content Analysis in Sports (MMSports'23) @ ACM Multimedi

Reducing Tarski to Unique Tarski (In the Black-Box Model)

We study the problem of finding a Tarski fixed point over the k-dimensional grid [n]^k. We give a black-box reduction from the Tarski problem to the same problem with an additional promise that the input function has a unique fixed point. It implies that the Tarski problem and the unique Tarski problem have exactly the same query complexity. Our reduction is based on a novel notion of partial-information functions which we use to fool algorithms for the unique Tarski problem as if they were working on a monotone function with a unique fixed point

Computing a Fixed Point of Contraction Maps in Polynomial Queries

We give an algorithm for finding an $\epsilon$-fixed point of a contraction map $f:[0,1]^k\mapsto[0,1]^k$ under the $\ell_\infty$-norm with query complexity $O (k^2\log (1/\epsilon ) )$.Comment: To appear in STOC'2

Large deviations and fluctuation theorems for cycle currents defined in the loop-erased and spanning tree manners: a comparative study

The cycle current is a crucial quantity in stochastic thermodynamics. The absolute and net cycle currents of a Markovian system can be defined in the loop-erased (LE) or the spanning tree (ST) manner. Here we make a comparative study between the large deviations and fluctuation theorems for the LE and ST currents, i.e. cycle currents defined in the LE and ST manners. First, we derive the exact joint distribution and the large deviation rate function for the LE currents of a system with a cyclic topology and also obtain the rate function for the ST currents of a general system. The relationship between the rate functions for the LE and ST currents is clarified. Furthermore, we examine various types of fluctuation theorems satisfied by the LE and ST currents and clarify their ranges of applicability. We show that both the absolute and net LE currents satisfy the strong form of all types of fluctuation theorems. In contrast, the absolute ST currents do not satisfy fluctuation theorems, while the net ST currents only satisfy the weak form of fluctuation theorems under the periodic boundary condition

The Model Inversion Eavesdropping Attack in Semantic Communication Systems

In recent years, semantic communication has been a popular research topic for its superiority in communication efficiency. As semantic communication relies on deep learning to extract meaning from raw messages, it is vulnerable to attacks targeting deep learning models. In this paper, we introduce the model inversion eavesdropping attack (MIEA) to reveal the risk of privacy leaks in the semantic communication system. In MIEA, the attacker first eavesdrops the signal being transmitted by the semantic communication system and then performs model inversion attack to reconstruct the raw message, where both the white-box and black-box settings are considered. Evaluation results show that MIEA can successfully reconstruct the raw message with good quality under different channel conditions. We then propose a defense method based on random permutation and substitution to defend against MIEA in order to achieve secure semantic communication. Our experimental results demonstrate the effectiveness of the proposed defense method in preventing MIEA.Comment: Accepted by 2023 IEEE Global Communications Conference (GLOBECOM

Zero-Shot Monocular Motion Segmentation in the Wild by Combining Deep Learning with Geometric Motion Model Fusion

Detecting and segmenting moving objects from a moving monocular camera is challenging in the presence of unknown camera motion, diverse object motions and complex scene structures. Most existing methods rely on a single motion cue to perform motion segmentation, which is usually insufficient when facing different complex environments. While a few recent deep learning based methods are able to combine multiple motion cues to achieve improved accuracy, they depend heavily on vast datasets and extensive annotations, making them less adaptable to new scenarios. To address these limitations, we propose a novel monocular dense segmentation method that achieves state-of-the-art motion segmentation results in a zero-shot manner. The proposed method synergestically combines the strengths of deep learning and geometric model fusion methods by performing geometric model fusion on object proposals. Experiments show that our method achieves competitive results on several motion segmentation datasets and even surpasses some state-of-the-art supervised methods on certain benchmarks, while not being trained on any data. We also present an ablation study to show the effectiveness of combining different geometric models together for motion segmentation, highlighting the value of our geometric model fusion strategy.Comment: Accepted by the 2024 IEEE/CVF Conference on Computer Vision and Pattern Recognition Workshops (CVPRW