SAGITTAL AND FRONTAL LOWER LIMBS KINETICS DURING STEPPING DOWN IN TAICHI ELDERLY

The aim was to compare the kinetic characteristics of the beginning stance phase during stepping down in Taichi and normal elderly. Nine elderly taichi subjects and eleven matched controls participated in the study. Whole body kinematics and ground reaction forces (GRF) were recorded using 10 Vicon cameras (250Hz) and two Kistler force plates (1000Hz). Sagittal and frontal kinetic parameters were calculated by using Visual3D software. Differences in variables between groups were tested using t-test. The results indicated hip extensor / knee flexor / ankle plantarflexor / support moment and peak hip/knee/ankle power were greater in Taichi group. It was concluded that Taichi group has ability to translate forward movement (hip moment / power), to control body (knee moment /power) and to absorption energy (ankle moment / power) in sagittal plane

Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery.

Neurite initiation is the first step in neuronal development and occurs spontaneously in soft tissue environments. Although the mechanisms regulating the morphology of migratory cells on rigid substrates in cell culture are widely known, how soft environments modulate neurite initiation remains elusive. Using hydrogel cultures, pharmacologic inhibition, and genetic approaches, we reveal that paxillin-linked endocytosis and adhesion are components of a bistable switch controlling neurite initiation in a substrate modulus-dependent manner. On soft substrates, most paxillin binds to endocytic factors and facilitates vesicle invagination, elevating neuritogenic Rac1 activity and expression of genes encoding the endocytic machinery. By contrast, on rigid substrates, cells develop extensive adhesions, increase RhoA activity and sequester paxillin from the endocytic machinery, thereby delaying neurite initiation. Our results highlight paxillin as a core molecule in substrate modulus-controlled morphogenesis and define a mechanism whereby neuronal cells respond to environments exhibiting varying mechanical properties

An Effective Mixture-Of-Experts Approach For Code-Switching Speech Recognition Leveraging Encoder Disentanglement

With the massive developments of end-to-end (E2E) neural networks, recent years have witnessed unprecedented breakthroughs in automatic speech recognition (ASR). However, the codeswitching phenomenon remains a major obstacle that hinders ASR from perfection, as the lack of labeled data and the variations between languages often lead to degradation of ASR performance. In this paper, we focus exclusively on improving the acoustic encoder of E2E ASR to tackle the challenge caused by the codeswitching phenomenon. Our main contributions are threefold: First, we introduce a novel disentanglement loss to enable the lower-layer of the encoder to capture inter-lingual acoustic information while mitigating linguistic confusion at the higher-layer of the encoder. Second, through comprehensive experiments, we verify that our proposed method outperforms the prior-art methods using pretrained dual-encoders, meanwhile having access only to the codeswitching corpus and consuming half of the parameterization. Third, the apparent differentiation of the encoders' output features also corroborates the complementarity between the disentanglement loss and the mixture-of-experts (MoE) architecture.Comment: ICASSP 202

Extending Bilingual WordNet via Hierarchical Word Translation Classification

PACLIC 23 / City University of Hong Kong / 3-5 December 200

Advanced materials for aqueous supercapacitors in the asymmetric design

AbstractSupercapacitors have been recognized as one of the promising energy storage devices in the future energy technology. In this perspective, rapid progress is made in the development of fundamental and applied aspects of supercapacitors. Various techniques have been developed specifically to estimate the specific capacitance. Numerous efforts have been made in the literature to increase the specific capacitance of electrode materials. Recently, researchers pay more attention on designing supercapacitors of asymmetric type with extending cell voltage and dissimilar materials with complementary working potentials. Researchers try to increase the specific energy of asymmetric supercapacitors (ASCs). Conversely, it is still a challenge to find a suitable operation conditions for ASCs in various designs, especially for the one with battery type electrode. In this review, we describe our recent research works and other reports on the preparation of various nanostructured electrode materials and the performances of both symmetric and asymmetric supercapacitors. Finally, we demonstrate effects of charge balance on the capacitive performances of ASCs which consist of one electrode material of the battery type and one capacitive material. We also demonstrate how to evaluate the charge capacities of both positive and negative electrode materials for this ASC application

The Chitinolytic Activities of Streptomyces sp. TH-11

Chitin is an abundant biopolymer composed of units of N-acetyl-D-glucosamine linked by β-1,4 glycosidic bonds. Chitin is the main component of the shells of mollusks, the cell wall of fungi and yeast and of the exoskeleton of crustaceans and insects. The degradation of chitin is catalyzed by chitinases that occur in a wide range of organisms. Among them, the chitinases from microorganisms are extremely important for the degradation and recycling of the carbon and nitrogen trapped in the large amount of insoluble chitin in nature. Streptomyces sp. TH-11 was isolated from the sediment of the Tou-Chien River, Taiwan. The chitinolytic enzyme activities were detected using a rapid in-gel detection method from the cell-free preparation of the culture medium of TH-11. The chitinolytic enzyme activity during prolonged liquid culturing was also analyzed by direct measurement of the chitin consumption. Decomposition of the exoskeleton of shrimps was demonstrated using electron microscopy and atomic force microscopy

AMP-Activated Protein Kinase Activation during Cardioplegia-Induced Hypoxia/Reoxygenation Injury Attenuates Cardiomyocytic Apoptosis via Reduction of Endoplasmic Reticulum Stress

Cardioplegic-induced H/R injury results in cardiomyocytic apoptosis. AMPK has been shown to reduce ER stress and the unfolded protein response (UPR). Whether AMPK activation can attenuate cardiomyocytic apoptosis after cardioplegia-induced H/R injury is unknown. Cardiomyocytes were exposed to simulated ischemia by incubation in a hypoxic chamber with intermittent cold cardioplegia solution infusion at 20-minute intervals and subsequently reoxygenated in a normoxic environment. Various doses of AMPK activators (AICAR or metformin) were given 2 days before H/R injury. The cardiomyocytes were harvested after reoxygenation for subsequent examination. With both AMPK activators, the antiapoptotic genes of ER stress and UPR, the subsequent production of proapoptotic proteins was attenuated, and the antiapoptotic proteins were elevated. The activity of the apoptotic effectors of ER stress was also reduced with AMPK activation. Moreover, TUNEL staining showed that AMPK activation significantly reduced the percentage of apoptotic cardiomyocytes after cardioplegia-induced H/R injury. Our results revealed that AMPK activation during cardioplegia-induced H/R injury attenuates cardiomyocytic apoptosis, via enhancement of antiapoptotic and reduction of proapoptotic responses, resulting from lessening ER stress and the UPR. AMPK activation may serve as a future pharmacological target to reduce H/R injury in the clinical setting

THE RELATIONSHIPS AMONG LMX, PSYCHOLOGICAL EMPOWERMENT, MOTIVATIONAL ORIENTATIONS AND INNOVATIVE BEHAVIOR

ABSTRACT In the past study, many researchers believed that leader-member exchange (LMX) had a significant influence on employee innovative behavior. This study extends previous research by examining the mediating role played by employee perceived psychological empowerment. This study also explores whether employees" motivational orientations have significant moderating effects on the relationship between employees" psychological empowerment and their innovative behaviors. Finally, this study examines whether the mediating effect of employees" psychological empowerment on the relation between LMX and innovative behaviors is, in turn, moderated by motivational orientations. Data were collected from 359 employees and their immediate supervisors in 46 companies in Taiwan. We tested the proposed relationships with robust data analytic techniques. Results were consistent with the hypothesized conceptual scheme, in that psychological empowerment mediated the relationship between LMX and innovative behavior when intrinsic or extrinsic motivation was high, but not when intrinsic or extrinsic motivation was low. On the basis of these findings, we conclude that the connection between LMX and innovative behavior in situations is more complex than was previously believed -there-by yielding a pattern of moderated mediation. JEL Classifications: M12, C12, L2