Erlotinib Achieved Partial Response in a Non-Small Cell Lung Cancer Patient with Gefitinib-Induced Interstitial Lung Disease

Interstitial lung disease (ILD) induced by epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib and erlotinib, is a rare but fatal complication of TKI treatment. Transfer to chemotherapy or continuation with TKI of reduced dose are alternative treatment strategies. We report a case of severe ILD in a non-small cell lung cancer patient treated with gefitinib. She experienced partial response with restarted low-dose EGFR-TKI erlotinib and corticosteroid treatment

Resolve negative cross section of quarkonium hadroproduction using soft gluon factorization

It was found that, using NRQCD factorization, the predicted $\chi_{cJ}$ hadroproduction cross section at large $p_T$ can be negative. The negative cross sections originate from terms proportional to plus function in ${^{3}\hspace{-0.6mm}P_{J}^{[1]}}$ channels, which are remnants of the infrared subtraction in matching the ${^{3}\hspace{-0.6mm}P_{J}^{[1]}}$ short-distance coefficients. In this article, we find that the above terms can be factorized into the nonperturbative ${^{3}\hspace{-0.6mm}S_{1}^{[8]}}$ soft gluon distribution function in the soft gluon factorization (SGF) framework. Therefore, the problem can be naturally resolved in SGF. With an appropriate choice of nonperturbative parameters, the SGF can indeed give positive predictions for $\chi_{cJ}$ production rates within the whole $p_T$ region. The production of $\psi(2S)$ is also discussed, and there is no negative cross section problem.Comment: 11 pages, 7 figure

A regioselectivity switch in Pd-catalyzed hydroallylation of alkynes.

By exploiting the reactivity of a vinyl-Pd species, we control the regioselectivity in hydroallylation of alkynes under Pd-hydride catalysis. A monophosphine ligand and carboxylic acid combination promotes 1,5-dienes through a pathway involving isomerization of alkynes to allenes. In contrast, a bisphosphine ligand and copper cocatalyst favor 1,4-dienes via a mechanism that involves transmetalation. Our study highlights how to access different isomers by diverting a common organometallic intermediate

Probing nuclear symmetry energy at high densities using pion, kaon, eta and photon productions in heavy-ion collisions

The high-density behavior of nuclear symmetry energy is among the most uncertain properties of dense neutron-rich matter. Its accurate determination has significant ramifications in understanding not only the reaction dynamics of heavy-ion reactions especially those induced by radioactive beams but also many interesting phenomena in astrophysics, such as the explosion mechanism of supernova and the properties of neutron stars. The heavy-ion physics community has devoted much effort during the last few years to constrain the high-density symmetry using various probes. In particular, the pion-/pion+ ratio has been most extensively studied both theoretically and experimentally. All models have consistently predicted qualitatively that the pion-/pion+ ratio is a sensitive probe of the high-density symmetry energy especially with beam energies near the pion production threshold. However, the predicted values of the pion-/pion+ ratio are still quite model dependent mostly because of the complexity of modeling pion production and reabsorption dynamics in heavy-ion collisions, leading to currently still controversial conclusions regarding the high-density behavior of nuclear symmetry energy from comparing various model calculations with available experimental data. As more pion-/pion+ data become available and a deeper understanding about the pion dynamics in heavy-ion reactions is obtained, more penetrating probes, such as the kaon+/kaon0 ratio, eta meson and high energy photons are also being investigated or planned at several facilities. Here, we review some of our recent contributions to the community effort of constraining the high-density behavior of nuclear symmetry energy in heavy-ion collisions. In addition, the status of some worldwide experiments for studying the high-density symmetry energy, including the HIRFL-CSR external target experiment (CEE) are briefly introduced.Comment: 10 pages, 10 figures, Contribution to the Topical Issue on Nuclear Symmetry Energy in EPJA Special Volum