Distributed Collaborative Monitoring in Software Defined Networks

We propose a Distributed and Collaborative Monitoring system, DCM, with the following properties. First, DCM allow switches to collaboratively achieve flow monitoring tasks and balance measurement load. Second, DCM is able to perform per-flow monitoring, by which different groups of flows are monitored using different actions. Third, DCM is a memory-efficient solution for switch data plane and guarantees system scalability. DCM uses a novel two-stage Bloom filters to represent monitoring rules using small memory space. It utilizes the centralized SDN control to install, update, and reconstruct the two-stage Bloom filters in the switch data plane. We study how DCM performs two representative monitoring tasks, namely flow size counting and packet sampling, and evaluate its performance. Experiments using real data center and ISP traffic data on real network topologies show that DCM achieves highest measurement accuracy among existing solutions given the same memory budget of switches

Using the teach-back method to improve postpartum maternal-infant health among women with limited maternal health literacy : a randomized controlled study

Peer reviewe

Diagnosis and Treatment of Hepatoblastoma: An Update

Hepatoblastoma is a rare but the most common solid tumor in children. The incidence is gradually increasing. The international collaboration among four centers in the world has greatly improved the prognosis of hepatoblastoma. They formed the Children’s Hepatic Tumor International Collaboration (CHIC) to standardize the staging system (2017 PRETEXT system) and the risk factors for tumor stratification. Multimodal therapy has become the standard for the management of hepatoblastoma, including surgical resection, liver transplantation, chemotherapy, and so on. Surgery is the primary treatment of early stage hepatoblastoma. Three-dimensional reconstruction is helpful for preoperative evaluation of large tumors, assisting extended hepatectomy for patients in PRETEXT III or IV. Neoadjuvant therapy is useful for reducing the tumor volume and increasing the resectability. Primary liver transplantation is recommended for advanced hepatoblastoma. The lungs are the most common metastatic organ, the treatment of which is critical for the patient’s long-term survival. We reviewed the recent progress in the diagnosis and treatment of hepatoblastoma

MOL#107706 Title Page Advances in Hypoxia-mediated Mechanisms in Hepatocellular Carcinoma

The number of words in the Abstract: 150 The number of words in the Introduction: 411 The number of words in the mainbody: 4537 The number of words in the Conclusion: 72 ABBREVIATIONS: 2-ME2, 2-Methoxyestradiol; CA-IX, carbonic anhydrase IX; caspase-1, cysteinyl aspartate specific proteinase-1; COX2, cyclooxygenase 2; CT, computerised tomography; DCE-MRI, dynamic contrast-enhanced magnetic resonance imaging; DEN, diethylnitrosamine; DFS, disease-free survival; EMT, epithelial-mesenchymal transition; ERK, MOL#107706 3 extracellular signal-regulated kinase; H2AX, H2A histone family, member X; GLUT1, glucose transporter 1; HBV, hepatitis B virus; HCC, hepatocelluar carcinoma; HIF-1/2, hypoxia inducible factor-1/2; HMGB1, high-mobility group protein 1; LSD1, lysine-specific demethylase-1; miR/miRNA, MicroRNA; MMPs, matrix metalloproteinases; mtDNA, mitochondrial DNA; NGB, neuroglobin; OS, overall survival; NET1, neuroepithelial cell transforming 1; p70S6K, p70-S6 Kinase 1; PFS, progression-free survival; PK, pyruvate kinase; pVHL, protein of von hippel lindau; Raf, RAF proto-oncogene serine/threonine-protein kinase; RFS, recurrence-free survival; ROS, oxygen reactive species; SDF1 -derived factor-1; TACE, transcatheter arterial chemoembolization; TGF, tumor growth factor; TLR, toll-like receptor; TNM, tumor, node, metastasis