Application of Non-dominated Sorting Genetic Algorithm in Calibration of HBV Rainfall-runoff Model: a Case Study of Tsengwen Reservoir Catchment in Southern Taiwan

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchive

Multi-chromatic narrow-energy-spread electron bunches from laser wakefield acceleration with dual-color lasers

A method based on laser wakefield acceleration with controlled ionization injection triggered by another frequency-tripled laser is proposed, which can produce electron bunches with low energy spread. As two color pulses co-propagate in the background plasma, the peak amplitude of the combined laser field is modulated in time and space during the laser propagation due to the plasma dispersion. Ionization injection occurs when the peak amplitude exceeds certain threshold. The threshold is exceeded for limited duration periodically at different propagation distances, leading to multiple ionization injections and separated electron bunches. The method is demonstrated through multi-dimensional particle-in-cell simulations. Such electron bunches may be used to generate multi-chromatic X-ray sources for a variety of applications.Comment: 5 pages, 5 figures; accepted by PR

The JNK inhibitor SP600125 enhances dihydroartemisinin-induced apoptosis by accelerating Bax translocation into mitochondria in human lung adenocarcinoma cells

AbstractThe C-Jun N-terminal Kinase (JNK) inhibitor SP600125 is widely used to inhibit the JNK-mediated Bax activation and cell apoptosis. However, this report demonstrates that SP600125 synergistically enhances the dihydroartemisinin (DHA)-induced human lung adenocarcinoma cell apoptosis by accelerating Bax translocation and subsequent intrinsic apoptotic pathway involving mitochondrial membrane depolarization, cytochrome c release, caspase-9 and caspase-3 activation. The dynamical analysis of GFP-Bax mobility inside single living cells using fluorescence recovery after photobleaching revealed that SP600125 aggravated the DHA-induced decrease of Bax mobility and Bax translocation. These results for the first time present a novel pro-apoptotic action of SP600125 in DHA-induced apoptosis