A Pilot Study of the Short Term Effectiveness and Safety of Amniotic Fluid in Severe Dry Eye Disease

The aim of this study was to evaluate if amniotic fluid (AF) mixed with artificial tears or soaked with a soft contact lens (SCL) as a treatment for severe dry eye disease (DED) would improve its signs or symptoms. In this retrospective pilot study 22 consecutive eyes of 11 patients with level 3 DED classified by DEWS 1 (Dry Eye WorkShop 1 2007), were included in the study between June 1 and September 30 in 2017. The study was conducted before DEWS II (Dry Eye WorkShop II 2017), which was published in October 2017. Therefore, DEWS II was not adopted for this study. Soft Contact Lens Acuvue Oasys of Plano with 8.8 base curve and 14 mm diameters by Johnson and Johnson were used to soak in FloGraft, which is an AF, for 30 minutes before placing in 12 eyes in Group 1. The contact lenses were placed in the left eye for 1 week. In Group 2, 10 eyes used 6 mL of artificial tears mixed with 0.25 mL of AF, which were applied to the eye four times a day for 1 week. No other eye medications were used. The eyes that were included had diffuse punctate staining and fast tear breaking times of <5 seconds with severe ocular symptoms (DEWS 1 level 3-4). Photos of fluorescein stain corneas before the treatment and 1 week after the treatment were used to compare the distribution of punctate staining as the objective outcomes for signs. Several questions adopted from the Ocular Surface disease Index (OSDI) about subjective symptoms before and after the treatment were asked, and documented on the chart. Improvement either in symptoms or signs or both of DED after 1 week at follow-up examination was recorded. Group 1, with SCL 46% had improvement after 1 week and Group 2, with artificial tears 50% had improvement after 1 week. Improvement means either symptom relief or comparatively decreased distribution of punctate staining on the cornea or both. No cases had inflammation, infection, irritation or blurred vision. We concluded that FloGraft as an AF can safely improve the symptoms or the signs of severe DED either as a mix with artificial tears or soaked with SCL by about 50% in this case series without evidence of irritation, inflammation or blurred vision in the short term

PixMIM: Rethinking Pixel Reconstruction in Masked Image Modeling

Masked Image Modeling (MIM) has achieved promising progress with the advent of Masked Autoencoders (MAE) and BEiT. However, subsequent works have complicated the framework with new auxiliary tasks or extra pre-trained models, inevitably increasing computational overhead. This paper undertakes a fundamental analysis of MIM from the perspective of pixel reconstruction, which examines the input image patches and reconstruction target, and highlights two critical but previously overlooked bottlenecks. Based on this analysis, we propose a remarkably simple and effective method, {\ourmethod}, that entails two strategies: 1) filtering the high-frequency components from the reconstruction target to de-emphasize the network's focus on texture-rich details and 2) adopting a conservative data transform strategy to alleviate the problem of missing foreground in MIM training. {\ourmethod} can be easily integrated into most existing pixel-based MIM approaches (\ie, using raw images as reconstruction target) with negligible additional computation. Without bells and whistles, our method consistently improves three MIM approaches, MAE, ConvMAE, and LSMAE, across various downstream tasks. We believe this effective plug-and-play method will serve as a strong baseline for self-supervised learning and provide insights for future improvements of the MIM framework. Code and models are available at \url{https://github.com/open-mmlab/mmselfsup/tree/dev-1.x/configs/selfsup/pixmim}.Comment: Update code link and add additional result

Threshold Effects in the Decay of Heavy b' and t' Quarks

A sequential fourth generation is still viable, but the t' and b' quarks are constrained to be not too far apart in mass. The t'{\to}bW and b'{\to}tW decay channels are still being pursued at the Tevatron, which would soon be surpassed by the LHC. We use a convolution method with up to five-body final state to study t' and b' decays. We show how the two decay branches for m_{b'} below the tW threshold, b'{\to}tW^* and t^*W, merge with b'{\to}tW above the threshold. We then consider the heavy-to-heavy transitions b'{\to}t^{\prime(*)}W^{(*)} (or t'{\to}b^{\prime(*)}W^{(*)}), as they are not suppressed by quark mixing. We find that, because of the threshold sensitivity of the branching fraction of t'{\to}b'W^* (or b'{\to}t'W^*), it is possible to measure the strength of the CKM mixing element V_{t'b} (or V_{tb'}), especially when it is rather small. We urge the experiments to pursue and separate the t'{\to}b'W^* (or b'{\to}t'W^*) decay in their search program

Focal Mechanism Solutions of the 2008 Wenchuan earthquake sequence from P-wave polarities and SH/P amplitude ratios: new results and implications

The 2008 Wenchuan earthquake, a major intraplate earthquake with Mw 7.9, occurred on the slowly deforming Longmenshan fault. To better understand the causes of this devastating earthquake, we need knowledge of the regional stress field and the underlying geodynamic processes. Here, we determine focal mechanism solutions (FMSs) of the 2008 Wenchuan earthquake sequence (WES) using both P-wave first-motion polarity data and SH/P amplitude ratio (AR) data. As P-wave polarities are more reliable information, they are given priority over SH/P AR, the latter of which are used only when the former has loose constraint on the FMSs. We collect data from three categories: (1) permanent stations deployed by the China Earthquake Administration (CEA); (2) the Western Sichuan Passive Seismic Array (WSPSA) deployed by Institute of Geology, CEA; (3) global stations from Incorporated Research Institutions for Seismology. Finally, 129 events with magnitude over Ms 4.0 in the 2008 WES are identified to have well-constrained FMSs. Among them, 83 are well constrained by P-wave polarities only as shown by Cai et al. (Earthq Sci 24(1):115–125, 2011), and the rest of which are newly constrained by incorporating SH/P AR. Based on the spatial distribution and FMSs of the WES, we draw following conclusions: (1) the principle compressional directions of most FMSs of the WES are subhorizontal, generally in agreement with the conclusion given by Cai et al. (2011) but with a few modifications that the compressional directions are WNW–ESE around Wenchuan and ENE–WSW around Qingchuan, respectively. The subhorizontal compressional direction along the Longmenshan fault from SW to NE seems to have a left-lateral rotation, which agrees well with regional stress field inverted by former researchers (e.g., Xu et al., Acta Seismol Sin 30(5), 1987; Acta Geophys Sin 32(6), 1989; Cui et al., Seismol Geol 27(2):234–242, 2005); (2) the FMSs of the events not only reflected the regional stress state of the Longmenshan region, but also were obviously controlled by the faults to some extent, which was pointed out by Cai et al. (2011) and Yi et al. (Chin J Geophys 55(4):1213–1227, 2012); (3) while the 2008 Wenchuan earthquake and some of its strong aftershocks released most of the elastic energy accumulated on the Longmenshan fault, some other aftershocks seem to occur just for releasing the elastic energy promptly created by the 2008 Wenchuan earthquake and some of its strong aftershocks. (4) Our results further suggest that the Longmenshan fault from Wenchuan to Beichuan was nearly fully destroyed by the 2008 Wenchuan earthquake and accordingly propose that there is less probability for great earthquakes in the middle part of the Longmenshan fault in the near future, although there might be a barrier to the southwest of Wenchuan and it is needed to pay some attention on it in the near future.Wenchuan Fault Scientific Drilling Progra

Enzyme-linked immunospot assay response to recombinant CFP-10/ESAT-6 fusion protein among patients with spinal tuberculosis: implications for diagnosis and monitoring of surgical therapy

SummaryObjectiveThis study aimed to assess the performance of a laboratory-developed recombinant CFP-10/ESAT-6 fusion protein (rCFP-10/ESAT-6)-based enzyme-linked immunospot (ELISPOT) assay for the diagnosis of spinal tuberculosis (TB) in China, and to evaluate the value of the ELISPOT assay for monitoring the efficacy of surgical treatment.MethodsIn the first part of the study, a total of 78 participants were consecutively recruited for ELISPOT using rCFP-10/ESAT-6 as a stimulus. The cutoff value for ELISPOT positivity was based on the results of receiver operating characteristic curve analysis. In the second part, this approach was evaluated in a prospective study including 102 patients with suspected spinal TB. Data on clinical characteristics of the patients and conventional laboratory results were collected, and blood samples were obtained for ELISPOT using rCFP-10/ESAT-6 as a stimulus.ResultsAmong the 102 patients with suspected spinal TB, 11 were excluded from the study. Twenty-three patients (25.2%) had culture-confirmed TB and 29 (31.9%) patients had probable TB. Among the spinal TB patients, the ELISPOT had a sensitivity of 82.7%, compared to a sensitivity of 61.5% for the purified protein derivative (PPD) skin test. The specificity was 87.2% for ELISPOT and 46.2% for the PPD skin test among 39 subjects with non-TB disease. The number of spot-forming cells and/or the positive rate of the ELISPOT assay were associated with aging, emaciation, and paravertebral abscess. The number of subjects with responses to rCFP-10/ESAT-6 slightly decreased after surgical treatment in spinal TB patients.ConclusionsA laboratory-developed rCFP-10/ESAT-6 ELISPOT assay is a useful adjunct to current tests for the diagnosis of spinal TB

SAMIHS: Adaptation of Segment Anything Model for Intracranial Hemorrhage Segmentation

Segment Anything Model (SAM), a vision foundation model trained on large-scale annotations, has recently continued raising awareness within medical image segmentation. Despite the impressive capabilities of SAM on natural scenes, it struggles with performance decline when confronted with medical images, especially those involving blurry boundaries and highly irregular regions of low contrast. In this paper, a SAM-based parameter-efficient fine-tuning method, called SAMIHS, is proposed for intracranial hemorrhage segmentation, which is a crucial and challenging step in stroke diagnosis and surgical planning. Distinguished from previous SAM and SAM-based methods, SAMIHS incorporates parameter-refactoring adapters into SAM's image encoder and considers the efficient and flexible utilization of adapters' parameters. Additionally, we employ a combo loss that combines binary cross-entropy loss and boundary-sensitive loss to enhance SAMIHS's ability to recognize the boundary regions. Our experimental results on two public datasets demonstrate the effectiveness of our proposed method. Code is available at https://github.com/mileswyn/SAMIHS .Comment: 5 pages, 3 figures, 2 table

Silicon nitride metalenses for unpolarized high-NA visible imaging

As one of nanoscale planar structures, metasurface has shown excellent superiorities on manipulating light intensity, phase and/or polarization with specially designed nanoposts pattern. It allows to miniature a bulky optical lens into the chip-size metalens with wavelength-order thickness, playing an unprecedented role in visible imaging systems (e.g. ultrawide-angle lens and telephoto). However, a CMOS-compatible metalens has yet to be achieved in the visible region due to the limitation on material properties such as transmission and compatibility. Here, we experimentally demonstrate a divergent metalens based on silicon nitride platform with large numerical aperture (NA~0.98) and high transmission (~0.8) for unpolarized visible light, fabricated by a 695-nm-thick hexagonal silicon nitride array with a minimum space of 42 nm between adjacent nanoposts. Nearly diffraction-limit virtual focus spots are achieved within the visible region. Such metalens enables to shrink objects into a micro-scale size field of view as small as a single-mode fiber core. Furthermore, a macroscopic metalens with 1-cm-diameter is also realized including over half billion nanoposts, showing a potential application of wide viewing-angle functionality. Thanks to the high-transmission and CMOS-compatibility of silicon nitride, our findings may open a new door for the miniaturization of optical lenses in the fields of optical fibers, microendoscopes, smart phones, aerial cameras, beam shaping, and other integrated on-chip devices.Comment: 16 pages, 7 figure