Response time of mean square slope to wind forcing: An empirical investigation

We present an empirical study of the response time of surface wave mean square slope to local wind forcing using data collected over 11 years by 46 discus buoys moored at a wide variety of locations. The response time is defined as the time lag at which the time dependence of the waves exhibits the highest correlation with that of the local wind speed. The response time at each location is found to be fairly stable, with the time varying between 0.4 and 1.8 h depending on the location. Examination of long‐term statistics reveals response time dependencies on wind speed magnitude, fetch, atmospheric stability, and wavelength. With the increasing reliance on satellite microwave remote sensing as a source of wind data, these results provide useful insights and bounds for their use.Key Points:Mean squared slope measured by buoys responds to wind forcing in 0.4–1.8 hThe response time depends on wind speed, fetch, atmospheric stability, and wavelengthPeer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142436/1/jgrc21693_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142436/2/jgrc21693.pd

Analysis of LiDAR Configurations on Off-road Semantic Segmentation Performance

This paper investigates the impact of LiDAR configuration shifts on the performance of 3D LiDAR point cloud semantic segmentation models, a topic not extensively studied before. We explore the effect of using different LiDAR channels when training and testing a 3D LiDAR point cloud semantic segmentation model, utilizing Cylinder3D for the experiments. A Cylinder3D model is trained and tested on simulated 3D LiDAR point cloud datasets created using the Mississippi State University Autonomous Vehicle Simulator (MAVS) and 32, 64 channel 3D LiDAR point clouds of the RELLIS-3D dataset collected in a real-world off-road environment. Our experimental results demonstrate that sensor and spatial domain shifts significantly impact the performance of LiDAR-based semantic segmentation models. In the absence of spatial domain changes between training and testing, models trained and tested on the same sensor type generally exhibited better performance. Moreover, higher-resolution sensors showed improved performance compared to those with lower-resolution ones. However, results varied when spatial domain changes were present. In some cases, the advantage of a sensor's higher resolution led to better performance both with and without sensor domain shifts. In other instances, the higher resolution resulted in overfitting within a specific domain, causing a lack of generalization capability and decreased performance when tested on data with different sensor configurations

CareerAdvance® Implementation Study Findings Through July 2013

This report examines fundamental changes in the CareerAdvance® program that directly relate to the experience and progress of participants through July 2013 (the end of the fourth program year) and the recruitment of Cohort 8 in April 2013. CareerAdvance® has evolved over time from a single nursing career training pathway in 2009 to four healthcare career pathways in 2013. The evolution of the program has led to many changes and has increased opportunities for program participants.U.S. Department of Health and Human Services’ Administration for Children and FamiliesRay Marshall Center for the Study of Human Resource

Stuck in Time: Negative Income Shock Constricts the Temporal Window of Valuation Spanning the Future and the Past

Insufficient resources are associated with negative consequences including decreased valuation of future reinforcers. To determine if these effects result from scarcity, we examined the consequences of acute, abrupt changes in resource availability on delay discounting-the subjective devaluation of rewards as delay to receipt increases. In the current study, 599 individuals recruited from Amazon Mechanical Turk read a narrative of a sudden change (positive, neutral, or negative) to one\u27s hypothetical future income and completed a delay discounting task examining future and past monetary gains and losses. The effects of the explicit zero procedure, a framing manipulation, was also examined. Negative income shock significantly increased discounting rates for gains and loses occurring both in the future and the past. Positive income windfalls significantly decreased discounting to a lesser extent. The framing procedure significantly reduced discounting under all conditions. Negative income shocks may result in short-term choices

A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, lethal malignancy that invades adjacent vasculatures and spreads to distant sites before clinical detection. Although invasion into the peripancreatic vasculature is one of the hallmarks of PDAC, paradoxically, PDAC tumors also exhibit hypovascularity. How PDAC tumors become hypovascular is poorly understood. We describe an organotypic PDAC-on-a-chip culture model that emulates vascular invasion and tumor-blood vessel interactions to better understand PDAC-vascular interactions. The model features a 3D matrix containing juxtaposed PDAC and perfusable endothelial lumens. PDAC cells invaded through intervening matrix, into vessel lumen, and ablated the endothelial cells, leaving behind tumor-filled luminal structures. Endothelial ablation was also observed in in vivo PDAC models. We also identified the activin-ALK7 pathway as a mediator of endothelial ablation by PDAC. This tumor-on-a-chip model provides an important in vitro platform for investigating the process of PDAC-driven endothelial ablation and may provide a mechanism for tumor hypovascularity.R01 EB000262 - NIBIB NIH HHS; TL1 TR001410 - NCATS NIH HHS; UC4 DK104196 - NIDDK NIH HHS; UH3 EB017103 - NIBIB NIH HHSPublished versio

Rapid uranium-series age screening of carbonates by laser ablation mass spectrometry

AbstractUranium-series dating is a critical tool in quaternary geochronology, including paleoclimate work, archaeology and geomorphology. Laser ablation (LA) methods are not as precise as most isotope dilution methods, but can be used to generate calendar ages rapidly, expanding the range of dating tools that can be applied to late Pleistocene carbonates. Here, existing LA methods are revisited for corals (cold- and warm-water) and speleothems spanning the last 343 thousand years (ka). Measurement of the required isotopes (238U, 234U, 230Th and 232Th) is achieved by coupling a laser system to a multi-collector inductively-coupled-plasma mass spectrometer (MC-ICPMS) using a combination of a single central ion counter and an array of Faraday cups. Each sample analysis lasts for ∼4.3 min, and fifty samples can be measured in 12 h with an automated set up, after a day of sample preparation. The use of different standard materials and laser systems had no significant effect on method accuracy. Uncertainty on the measured (230Th/238U) activity ratios ranges from 5.4% to 7.6% for (230Th/238U) ratios equal to 0.7 and 0.1 respectively. Much of this uncertainty can be attributed to the heterogeneity of the standard material (230Th/238U) at the length scale of LA. A homogeneous standard material may therefore improve measurement uncertainty but is not a requirement for age-screening studies. The initial (234U/238U) of coral samples can be determined within ∼20‰, making it useful as a first indicator of open-system behaviour. For cold-water corals, success in determination of (232Th/238U) – which can affect final age accuracy – by LA depended strongly on sample heterogeneity. Age uncertainties (2 sigma) ranged from <0.8 ka at 0–10 ka, ∼1.5 ka at 20 ka to ∼15 ka at 125 ka. Thus, we have demonstrated that U-series dating by LA-MC-ICPMS can be usefully applied to a range of carbonate materials as a straightforward age-screening technique

Blue-Light-Emitting Color Centers in High-Quality Hexagonal Boron Nitride

Light emitters in wide band gap semiconductors are of great fundamental interest and have potential as optically addressable qubits. Here we describe the discovery of a new color center in high-quality hexagonal boron nitride (h-BN) with a sharp emission line at 435 nm. The emitters are activated and deactivated by electron beam irradiation and have spectral and temporal characteristics consistent with atomic color centers weakly coupled to lattice vibrations. The emitters are conspicuously absent from commercially available h-BN and are only present in ultra-high-quality h-BN grown using a high-pressure, high-temperature Ba-B-N flux/solvent, suggesting that these emitters originate from impurities or related defects specific to this unique synthetic route. Our results imply that the light emission is activated and deactivated by electron beam manipulation of the charge state of an impurity-defect complex