Made in Italy (by the Chinese) : economic restructuring and the politics of migration

People around the world are on the move and settling in new, unexpected places. In Prato, Italy, Chinese immigrants now run most of the city’s textiles-apparel companies and even subcontract for such leading designers as Giorgio Armani and Dolce & Gabbana. Italian products once made by Italian workers are now increasingly made…by the Chinese! I argue that this development resulted from an uncanny synchronicity between their business approach and the demands of Italy’s local, familybased, small-batch production environment. In other words, the Chinese thrived because they fit in well with the unique makeup and demands of Italian industry.Personas de todo el mundo se desplazan y establecen en lugares nuevos e inesperados. En Prato, Italia, los inmigrantes chinos dirigen la mayoría de las empresas de confección textil de la ciudad e incluso subcontratan la confección de famosos diseñadores como Giorgio Armani o Dolce & Gabbana. Los productos italianos, antaño fabricados por trabajadores italianos, ahora cada vez están más hechos. . . ¡por chinos! Este desarrollo es el resultado de una extraordinaria sincronía entre su propia perspectiva empresarial y la estructura de producción local italiana a pequeña escala y basada en la familia. En definitiva, los chinos prosperan porque se adaptan bien al tipo de producción y a la demanda de la industria italiana

TCM Database@Taiwan: The World's Largest Traditional Chinese Medicine Database for Drug Screening In Silico

Rapid advancing computational technologies have greatly speeded up the development of computer-aided drug design (CADD). Recently, pharmaceutical companies have increasingly shifted their attentions toward traditional Chinese medicine (TCM) for novel lead compounds. Despite the growing number of studies on TCM, there is no free 3D small molecular structure database of TCM available for virtual screening or molecular simulation. To address this shortcoming, we have constructed TCM Database@Taiwan (http://tcm.cmu.edu.tw/) based on information collected from Chinese medical texts and scientific publications. TCM Database@Taiwan is currently the world's largest non-commercial TCM database. This web-based database contains more than 20,000 pure compounds isolated from 453 TCM ingredients. Both cdx (2D) and Tripos mol2 (3D) formats of each pure compound in the database are available for download and virtual screening. The TCM database includes both simple and advanced web-based query options that can specify search clauses, such as molecular properties, substructures, TCM ingredients, and TCM classification, based on intended drug actions. The TCM database can be easily accessed by all researchers conducting CADD. Over the last eight years, numerous volunteers have devoted their time to analyze TCM ingredients from Chinese medical texts as well as to construct structure files for each isolated compound. We believe that TCM Database@Taiwan will be a milestone on the path towards modernizing traditional Chinese medicine.National Science Council of Taiwan (NSC 99-2221-E-039-013-)China Medical UniversityAsia UniversityAsia University (CMU98-ASIA-09)Taiwan. Dept. of Health (Clinical Trial and Research Center of Excellence (DOH99-TD-B-111-004))Taiwan. Dept. of Health (Cancer Research Center of Excellence (DOH99-TD-C-111-005)

Towards A Unified Neural Architecture for Visual Recognition and Reasoning

Recognition and reasoning are two pillars of visual understanding. However, these tasks have an imbalance in focus; whereas recent advances in neural networks have shown strong empirical performance in visual recognition, there has been comparably much less success in solving visual reasoning. Intuitively, unifying these two tasks under a singular framework is desirable, as they are mutually dependent and beneficial. Motivated by the recent success of multi-task transformers for visual recognition and language understanding, we propose a unified neural architecture for visual recognition and reasoning with a generic interface (e.g., tokens) for both. Our framework enables the principled investigation of how different visual recognition tasks, datasets, and inductive biases can help enable spatiotemporal reasoning capabilities. Noticeably, we find that object detection, which requires spatial localization of individual objects, is the most beneficial recognition task for reasoning. We further demonstrate via probing that implicit object-centric representations emerge automatically inside our framework. Intriguingly, we discover that certain architectural choices such as the backbone model of the visual encoder have a significant impact on visual reasoning, but little on object detection. Given the results of our experiments, we believe that visual reasoning should be considered as a first-class citizen alongside visual recognition, as they are strongly correlated but benefit from potentially different design choices

Node and Edge Differential Privacy for Graph Laplacian Spectra: Mechanisms and Scaling Laws

This paper develops a framework for privatizing the spectrum of the graph Laplacian of an undirected graph using differential privacy. We consider two privacy formulations. The first obfuscates the presence of edges in the graph and the second obfuscates the presence of nodes. We compare these two privacy formulations and show that the privacy formulation that considers edges is better suited to most engineering applications. We use the bounded Laplace mechanism to provide differential privacy to the eigenvalues of a graph Laplacian, and we pay special attention to the algebraic connectivity, which is the Laplacian's second smallest eigenvalue. Analytical bounds are presented on the the accuracy of the mechanisms and on certain graph properties computed with private spectra. A suite of numerical examples confirms the accuracy of private spectra in practice.Comment: arXiv admin note: text overlap with arXiv:2104.0065

Does Visual Pretraining Help End-to-End Reasoning?

We aim to investigate whether end-to-end learning of visual reasoning can be achieved with general-purpose neural networks, with the help of visual pretraining. A positive result would refute the common belief that explicit visual abstraction (e.g. object detection) is essential for compositional generalization on visual reasoning, and confirm the feasibility of a neural network "generalist" to solve visual recognition and reasoning tasks. We propose a simple and general self-supervised framework which "compresses" each video frame into a small set of tokens with a transformer network, and reconstructs the remaining frames based on the compressed temporal context. To minimize the reconstruction loss, the network must learn a compact representation for each image, as well as capture temporal dynamics and object permanence from temporal context. We perform evaluation on two visual reasoning benchmarks, CATER and ACRE. We observe that pretraining is essential to achieve compositional generalization for end-to-end visual reasoning. Our proposed framework outperforms traditional supervised pretraining, including image classification and explicit object detection, by large margins.Comment: NeurIPS 202

Hybrid neural network approaches to predict drug–target binding affinity for drug repurposing: screening for potential leads for Alzheimer’s disease

Alzheimer’s disease (AD) is a neurodegenerative disease that primarily affects elderly individuals. Recent studies have found that sigma-1 receptor (S1R) agonists can maintain endoplasmic reticulum stress homeostasis, reduce neuronal apoptosis, and enhance mitochondrial function and autophagy, making S1R a target for AD therapy. Traditional experimental methods are costly and inefficient, and rapid and accurate prediction methods need to be developed, while drug repurposing provides new ways and options for AD treatment. In this paper, we propose HNNDTA, a hybrid neural network for drug–target affinity (DTA) prediction, to facilitate drug repurposing for AD treatment. The study combines protein–protein interaction (PPI) network analysis, the HNNDTA model, and molecular docking to identify potential leads for AD. The HNNDTA model was constructed using 13 drug encoding networks and 9 target encoding networks with 2506 FDA-approved drugs as the candidate drug library for S1R and related proteins. Seven potential drugs were identified using network pharmacology and DTA prediction results of the HNNDTA model. Molecular docking simulations were further performed using the AutoDock Vina tool to screen haloperidol and bromperidol as lead compounds for AD treatment. Absorption, distribution, metabolism, excretion, and toxicity (ADMET) evaluation results indicated that both compounds had good pharmacokinetic properties and were virtually non-toxic. The study proposes a new approach to computer-aided drug design that is faster and more economical, and can improve hit rates for new drug compounds. The results of this study provide new lead compounds for AD treatment, which may be effective due to their multi-target action. HNNDTA is freely available at https://github.com/lizhj39/HNNDTA

Efficient Parallel Algorithms and Data Structures Related to Trees

The main contribution of this dissertation proposes a new paradigm, called the parentheses matching paradigm. It claims that this paradigm is well suited for designing efficient parallel algorithms for a broad class of nonnumeric problems. To demonstrate its applicability, we present three cost-optimal parallel algorithms for breadth-first traversal of general trees, sorting a special class of integers, and coloring an interval graph with the minimum number of colors