Child Health CheckPoint Material Disclaimer

This document describes the disclaimers relating to the Child Health CheckPoint datasets and related material

Child Health CheckPoint Labelled Parent Questionnaire

Parent participants completed the CheckPoint Parent questionnaire on an iPad or laptop. This annotated version of the questionnaire provides information on branching rules, corresponding variable names, and response type and coding.</p

Child Health CheckPoint Rationale document

The Child Health CheckPoint Rationale document describes the source of each measure, it's rationale for inclusion in CheckPoint, how it was administered and scored, and any modifications from the original measure or previous LSAC waves

Child Health CheckPoint Parent/Guardian Information and Consent Booklet

This Information and Consent Booklet was provided to parents and guardians of study children. It gives important information about what is involved in participating in the Child Health CheckPoint study. The booklet also includes copies of the consent form

Child Health CheckPoint Labelled Child Questionnaire

Child participants completed the CheckPoint Child questionnaire on an iPad or laptop. This annotated version of the questionnaire provides information on branching rules, corresponding variable names, and response type and coding

Convergence of Mitogenic Signalling Cascades from Diverse Classes of Receptors at the Cyclin D–Cyclin-Dependent

The commitment of mammalian cells in late G 1 to replicate the genome and divide in response to mitogenic growth factors operating via tyrosine kinase receptors depends on phosphorylation of the retinoblastoma protein (pRb), a process controlled by cyclin D-associated cyclin-dependent kinases (cdks) and their inhibitors. This study addressed the issue of whether also other mitogenic signalling cascades require activation of cyclin D-associated kinases or whether any mitogenic pathway can bypass the cyclin D-pRb checkpoint. We show that mitogenic signal transduction pathways from three classes of receptors, the membrane tyrosine kinase receptors activated by serum mitogens or epidermal growth factor, estrogen receptors triggered by estradiol, and the cyclic AMP-dependent signalling from G-protein-coupled thyrotropin receptors, all converge and strictly require the cyclin D-cdk activity to induce S phase in human MCF-7 cells and/or primary dog thyrocytes. Combined microinjection and biochemical approaches showed that whereas these three mitogenic cascades are sensitive to the p16 inhibitor of cdk4/6 and/or cyclin D1-neutralizing antibody and able to induce pRb kinase activity, their upstream biochemical routes are distinct as demonstrated by their differential sensitivity to lovastatin and requirements for mitogen-activated protein kinases whose sustained activation is seen only in the growth factor-dependent pathway. Taken together, these results support the candidacy of the cyclin D-cdk-pRb interplay for the convergence step of multiple signalling cascades and a mechanism contributing t

Child Health CheckPoint Data Dictionary

The CheckPoint Data Dictionary describes each variable in the CheckPoint dataset included in the LSAC Wave 7 Release (Jan 2019).<br