Inhibition Planktonic and Bio film Growth of Candida Albicans by Plant Extract Alone and in combination with Fluconazole

This study was to evaluate the efficacy of Methanolic extract of G. superba L in combination with Fluconazole against biofilm development and mature biofilms of C. albicans. Synergism between MEGS and Fluconazole combination against biofilm formation was evident with FICI of 0.187. Combination of MEGS and Fluconazole did not have synergistic potential against mature biofilm growth, evidenced in FICI of 0.916. MIC of standard Fluconazole was found to be 0.5 and >0.5 in biofilm development and mature biofilm respectively