Primary hepatoid carcinoma of the ovary: A case report

Primary hepatoid carcinoma of the ovary (HCO) is a very rare type of high-grade invasive malignant ovarian tumor with hepatic differentiation and production of á-fetoprotein (AFP). We describe a 78-year-old Moroccan woman who presented to our hospital with abdominal distension andpurplish nodules infiltrating the para umbilical skin with weight loss and impairment of her performance status. Excisional biopsy of the paraumbilical nodule revealed a cutaneous localization of moderately   differentiated adenocarcinoma and pelvic ultrasonography noted the presence of a tumoral right adnexal mass. The patient underwent an exploratory laparoscopy which found peritoneal carcinomatosis with pelvic adhesions allowing only a peritoneal biopsy. Diagnosis of primary hepatoid carcinoma of the ovary was established on the basis of classic   histopathologic findings, immunohistochemical staining and marked elevation in serum of á-fetoprotein more than the carbohydrate antigen 125. The patient received 3 cycles of chemotherapy based on Carboplatin and Paclitaxel with disease progression. No second line chemotherapy was given because of the drop of patient's performance status to 3. The patient died one month later