Ankle brachial pressure index to assess atherosclerotic risk in hypertensive subjects

Background: This research was planned to study correlation of ankle brachial pressure index (ABPI) with clinical features, laboratory investigations and anthropometric measurements in patients of essential hypertension and to establish association of atherosclerosis risk in hypertensive subject.Methods: This prospective observational year-long study was conducted after the institutional ethics committee approval in outpatient department of a tertiary care hospital. 153 adult non-pregnant patients were enrolled after written informed consent. Out of these, 51 patients each were of stage I hypertension, stage II hypertension and normal blood pressure. The ABPI were measured in the posterior tibial arteries using a Doppler ultrasound probe. The detailed demographic and anthropometric data was entered in proforma and data statistically analyzed.Results: In our study 28 (55%) out of 51 patients in stage II Hypertension had low ABPI as compared to 23 (45%) out of 51 patients in stage I Hypertension. No patients with normal blood pressure had low ABPI. There is significant correlation of stage of hypertension and ABPI (p <0.001). Mean ABPI (0.9102) in stage II hypertensive was low as compared to stage I hypertensive (0.9124) and normotensive subjects (1.0263). ABPI was inversely correlated with lipid profile. The hypertensive subjects with duration of hypertension for more than 5 years, the mean ABPI was significantly lower (0.8773) than those hypertensive subjects who had duration of hypertension less than 5 years (0.9526) (p 0.001).Conclusions: ABPI proves to be a non-invasive, bed side modality to assess the atherosclerotic risk in hypertensive patients.

Mini open anterolateral rotator cuff tear repair with the help of suture anchor

Background: It is generally accepted that mini open rotator cuff tear repair with the help of suture anchor gives satisfactory results in the long term, although most studies have so far shown a fairly high rate of good structural and functional outcome. The purpose of this study is to asses functional outcome of mini-open anterolateral rotator cuff tear repair with the help of suture anchor. Method: The 30 consecutive rotator cuff tear patients were selected from outpatient department at medical college. All patients were diagnosed with full thickness rotator cuff tear and subsequently treated with mini-open anterolateral approach technique. Each patient was clinically assessed with DASH questionnaire and constant Murley score for their satisfaction. Results: After a minimum of 12 month follow up period, the average clinical outcome scores all improved significantly at the time of final follow up. Conclusions: Patient with mini-open anterolateral rotator cuff tear repair with the help of anchor suture showed improvement in their functional outcome and range of motion.

Evaluation of clinical and functional outcome of total hip arthroplasty in avascular necrosis of head of femur in adults

Background: Aim of the study was to evaluate clinical and functional outcome of bipolar hemiarthroplasty in avascular necrosis (AVN) of HIP in adults. Methods: Thirty patients of either sex between age group 20-80 years of age came for the treatment at government medical college and hospital Aurangabad. Between December 2020 to December 2022. Patients were followed every day till the discharge. Patients were discharged after they were mobilised with assistance of physiotherapist. Functional and clinical outcome was measured at 6, 12 and 24 weeks postoperatively according to Harris hip score (HHS). Results: the methods show significant improvement in HHS in patient undergoing total hip replacement. Conclusions: total hip replacement is a very good option for AVN of head of femur in all age groups

An alum [KAl (SO4)2.12H2O] catalyzed microwave assisted multicomponent synthesis of bioactive functionalized benzylpyrazolyl coumarin and quinolinone derivatives in PEG

An efficient and environmentally benign method has been developed for the synthesis of benzylpyrazolyl coumarin and quinolinone derivatives, hydroxy coumarin derivatives using Alum [KAl (SO4)2.12H2O] catalyst and Polyethylene glycol as green solvent under microwave condition. Keywords: Knoevenagel, Michael addition reaction, coumarins, quinolinones, alum, polyethylene glycol, multicomponent microwave irradiation method

Rapid and efficient one-pot microwave-assisted synthesis of 2-phenylimidazo[1,2-<i>a</i>]pyridines and 2-phenylimidazo[1,2-<i>a</i>]quinoline in water–PEG-400

<p>An effective, expeditious, environmentally benign one-pot synthesis of 2-phenylimidazo[1,2-<i>a</i>]pyridines and 2-phenylimidazo[1,2-<i>a</i>]quinoline from easily available starting materials as aromatic carbonyl compound, 2-amino pyridine, succinamide, and <i>in situ</i> generated α-iodo acetophenone in combination with green solvent PEG-400 and water (2:1) under microwave irradiation. The newly developed protocol with excellent yield of product in very short time of reaction by avoiding the use of lachrymatric α-chloro and α-bromocarbonyl compounds, volatile, toxic organic and hazardous solvents, reagents is the advantage of this research work. The final products were confirmed by their characterization data such as ¹H NMR, ¹³C NMR, high resolution mass spectrometry (HRMS) and were compared with its reported method.</p

Efficient removal of toxic Cd(II) ions from waste streams by a novel modified biodegradable magnetic sorbent

Environmental remediation is challenged by the removal of harmful heavy metal contaminants from industrial waste streams. Because of its low cost and great effectiveness, adsorption is a commonly used separation method, particularly in environmental cleanup. Inexpensive, biodegradable orange peel-chitosan and Fe3O4 magnetic particles (Fe3O4-OP-CS) were combined in a simple process to create an innovative composite. Their structure and morphology were studied using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and thermogravimetric analyses. At room temperature, adsorption experiments were conducted, and variables such pH, initial metal ion concentration, and contact time were tuned to maximize Cd(II) removal. The results of harmful Cd(II) sorption using the synthesized composite showed that its adsorption kinetics and sorption isotherm confirm to the pseudo-second-order and Langmuir models, respectively. The thermodynamic analysis showed that Cd(II) adsorption is exothermic and spontaneous. In comparison to previously reported materials, the new composite also displayed a high adsorption capacity (qmax) of 251.88 mg/g. The composite showed three cycles of reuse and might still be able to promise a maximum saturated adsorption capacity of more than 92%, and tolerance to related metal ions (Mn, Fe, Pb, and Cr) present in Cd (II). In addition to Cd(II) sorption for preconcentration and remediation before Cd testing from waste, digested tobacco, and battery samples, the proposed method is also credible for Cd(II) sorption