Synthesis and evaluation of 1,2,4-triazole derivatives as antimicrobial, antifungal and anthelmintic agents

Current research work is focused on incorporation of thiosemicarbazide, triazole in one framework and observed for antifungal, antibacterial and anthelmintic activities. Derivatives of 1,2,4-triazole-3-thiol are synthesized with thiosemicarbazide and semicarbazide as a starting material. Thiosemicarbazide are subjected to intermolecular cyclization in alkaline medium followed by acidification to give 1,2,4-triazole-3-thiol. Equimolar mixture of thiosemicarbazide and different consecutive acids are heated, fusion occurred to give different triazoles derivatives. The minimum inhibitory concentrations for synthesized compounds are in the range of 3.12-25 μg/mL

Synthesis and evaluation of 1,2,4-triazole derivatives as antimicrobial, antifungal and anthelmintic agents

994-998Current research work is focused on incorporation of thiosemicarbazide, triazole in one framework and observed for antifungal, antibacterial and anthelmintic activities. Derivatives of 1,2,4-triazole-3-thiol are synthesized with thiosemicarbazide and semicarbazide as a starting material. Thiosemicarbazide are subjected to intermolecular cyclization in alkaline medium followed by acidification to give 1,2,4-triazole-3-thiol. Equimolar mixture of thiosemicarbazide and different consecutive acids are heated, fusion occurred to give different triazoles derivatives. The minimum inhibitory concentrations for synthesized compounds are in the range of 3.12-25 μg/mL

TOLERANCE STACK UP ANALYSIS AND SIMULATION USING VISUALIZATION VSA

A AB BS ST TR RA AC CT T Tolerance analysis is used to predict the effects of manufacturing variation on finished products. Either design tolerances or manufacturing process data may be used to define the variation. Tolerances stack up in machining results from using operational datum that are different from design datum. It is inevitable due to economic considerations of the machining process. Conventional methods used for tolerance stack up analysis include worst-case and statistical analysis. These methods are based on strong assumptions and have certain drawbacks. VIS-VSA is a powerful dimensional analysis tool used to simulate manufacturing and assembly processes and predict the amounts and causes of variation VIS-VSA can help reduce the negative impact of variation on product dimensional quality, cost and time to market

Early correction of unilateral scissor bite using transforce appliance and modified twin block appliance

Early treatment of scissor bite has been advocated mainly to prevent function jaw shift that can eventually lead to permanent skeletal asymmetry and temporomandibular joint pathosis. Although unilateral scissor bite is more common, most of the times, bilateral mandibular expansion is indicated. Lingual transforce appliance can be useful in such cases. This article presents a patient with unilateral scissor bite in mixed dentition with alveolar narrowing. Transforce appliance was used for scissor bite correction followed by modified twin block appliance for stabilization and settling of occlusion till the eruption of premolars. The case was finished with fixed mechanotherapy. Two years after completion of treatment, results were well maintained. Our results suggest that lingual transforce appliance along with careful management of occlusion is effective in the early management of severe unilateral scissor bite

Proceedings of National Conference on Relevance of Engineering and Science for Environment and Society

This conference proceedings contains articles on the various research ideas of the academic community and practitioners presented at the National Conference on Relevance of Engineering and Science for Environment and Society (R{ES}2 2021). R{ES}2 2021 was organized by Shri Pandurang Pratishthan’s, Karmayogi Engineering College, Shelve, Pandharpur, India on July 25th, 2021. Conference Title: National Conference on Relevance of Engineering and Science for Environment and SocietyConference Acronym: R{ES}2 2021Conference Date: 25 July 2021Conference Location: Online (Virtual Mode)Conference Organizers: Shri Pandurang Pratishthan’s, Karmayogi Engineering College, Shelve, Pandharpur, India