Perinatal exposure of rats to a maternal diet with varying protein quantity and quality affects the risk of overweight in female adult offspring

The maternal protein diet during the perinatal period can program the health of adult offspring. This study in rats evaluated the effects of protein quantity and quality in the maternal diet during gestation and lactation on weight and adiposity in female offspring. Six groups of dams were fed a high-protein (HP; 47% protein) or normal-protein (NP; 19% protein) isocaloric diet during gestation (G) using either cow's milk (M), pea (P) or turkey (T) proteins. During lactation, all dams received the NP diet (protein source unchanged). From postnatal day (PND) 28 until PND70, female pups (n=8) from the dam milk groups were exposed to either an NP milk diet (NPMW) or to dietary self-selection (DSS). All other pups were only exposed to DSS. The DSS design was a choice between five food cups containing HPM, HPP, HPT, carbohydrates or lipids. The weights and food intakes of the animals were recorded throughout the study, and samples from offspring were collected on PND70. During the lactation and postweaning periods, body weight was lower in the pea and turkey groups (NPG and HPG) versus the milk group (P<.0001). DSS groups increased their total energy and fat intakes compared to the NPMW group (P<.0001). In all HPG groups, total adipose tissue was increased (P=.03) associated with higher fasting plasma leptin (P<.05). These results suggest that the maternal protein source impacted offspring body weight and that protein excess during gestation, irrespective of its source, increased the risk of adiposity development in female adult offspring

Communications étude de transfert de pollution par temps de pluie sur le réseau d'assainissement du district urbain d'Arras

Dans le cadre des études menées par le District Urbain d'Arras en collaboration avec l'Agence de l'Eau Artois-Picardie sur le fonctionnement des réseaux d'assainissement districaux, une étude de transfert de pollution par temps de pluie a été réalisée à l'aide du logiciel FLUPOL [1], [2]

A Fail-safe Microcontroleur for Railway Signalling

International audienc

Description of a safe programming microprocessing unit for railway signalling

The authors present the architecture of a micro-controller (MAPS) used to drive the `on ground' function of a railway network. This microcontroller must replace safety discrete components actually used in critical system. To take up this challenge, MAPS profits from the integration on the same chip of both a self-checking circuit and two fail-safe interfaces. It also guarantees a number of failures per hour much lower than that achieved in the existing system

P186: Différences d’organisation spatiale des neurones pro-opiomélanocortine (POMC) dans le noyau arqué de l’hypothalamus de souris sensibles ou résistantes à l’obésité

International audienc

L’accès à de l’eau sucrée a des conséquences délétères mais réversibles, plus marquées chez la souris prédisposée à l’obésité que chez la souris résistante

International audienc

Rôle de l’AMPK, mTOR et GCN2 dans la détection des AA dans des hépatocytes en culture primaire

International audienc

Apigenin and tangeretin enhance gap junctional intercellular communication in rat liver epithelial cells

National audienc