Dehydrolysine containing analogues of tuftsin: synthesis and bioactivity

Two analogues of tuftsin containing α,β-dehydrolysine. Thr-Δ-Lys-Pro-Arg (1) and Leu-ΔLys-Pro-Arg (2) have been synthesised. Presence of ΔLys moiety has been confirmed by 1H NMR and aminoacid analysis. Analogue (1) and (2) have been checked for their phagocytic activity

Allelopathy for weed control in agricultural systems

Weeds are a hidden foe for crop plants, interfering with their functions and suppressing their growth and development. Yield losses of ~34% are caused by weeds among the major crops, which are grown worldwide. These yield losses are higher than the losses caused by other pests in the crops. Sustainable weed management is needed in the wake of a huge decline in crop outputs due to weed pressure. A diversity in weed management tools ensures sustainable weed control and reduces chances of herbicide resistance development in weeds. Allelopathy as a tool, can be importantly used to combat the challenges of environmental pollution and herbicide resistance development. This review article provides a recent update regarding the practical application of allelopathy for weed control in agricultural systems. Several studies elaborate on the significance of allelopathy for weed management. Rye, sorghum, rice, sunflower, rape seed, and wheat have been documented as important allelopathic crops. These crops express their allelopathic potential by releasing allelochemicals which not only suppress weeds, but also promote underground microbial activities. Crop cultivars with allelopathic potentials can be grown to suppress weeds under field conditions. Further, several types of allelopathic plants can be intercropped with other crops to smother weeds. The use of allelopathic cover crops and mulches can reduce weed pressure in field crops. Rotating a routine crop with an allelopathic crop for one season is another method of allelopathic weed control. Importantly, plant breeding can be explored to improve the allelopathic potential of crop cultivars. In conclusion, allelopathy can be utilized for suppressing weeds in field crops. Allelopathy has a pertinent significance for ecological, sustainable, and integrated weed management systems

Allelopathy for weed control in agricultural systems

Weeds are a hidden foe for crop plants, interfering with their functions and suppressing their growth and development. Yield losses of ∼34 are caused by weeds among the major crops, which are grown worldwide. These yield losses are higher than the losses caused by other pests in the crops. Sustainable weed management is needed in the wake of a huge decline in crop outputs due to weed pressure. A diversity in weed management tools ensures sustainable weed control and reduces chances of herbicide resistance development in weeds. Allelopathy as a tool, can be importantly used to combat the challenges of environmental pollution and herbicide resistance development. This review article provides a recent update regarding the practical application of allelopathy for weed control in agricultural systems. Several studies elaborate on the significance of allelopathy for weed management. Rye, sorghum, rice, sunflower, rape seed, and wheat have been documented as important allelopathic crops. These crops express their allelopathic potential by releasing allelochemicals which not only suppress weeds, but also promote underground microbial activities. Crop cultivars with allelopathic potentials can be grown to suppress weeds under field conditions. Further, several types of allelopathic plants can be intercropped with other crops to smother weeds. The use of allelopathic cover crops and mulches can reduce weed pressure in field crops. Rotating a routine crop with an allelopathic crop for one season is another method of allelopathic weed control. Importantly, plant breeding can be explored to improve the allelopathic potential of crop cultivars. In conclusion, allelopathy can be utilized for suppressing weeds in field crops. Allelopathy has a pertinent significance for ecological, sustainable, and integrated weed management systems

Role of competition in managing weeds: an introduction to the special issue

Weeds represent a significant challenge to successful crop production. Highly effective and sustainable weed control is required in order to meet global food demand. In this context, excessive use of herbicides has resulted in serious environmental and ecological issues. There are several weed control options which neither harm the environment nor require a significant increase in cost of production. Improving crop competition is particularly important and attractive among such options, which can be achieved by using crop cultivars possessing a competitive advantage over weeds, and manipulating the seed rate and direction of crop rows. Crop cultivars possessing traits such as fast germination, quick growth, high biomass, and large leaf area have a competitive advantage over weeds. Sowing such cultivars has been shown to suppress weeds in various crops. The use of high seed rates and narrow row spacing, if properly manipulated, can cause a significant decrease in weed proliferation in the crops. These techniques (cultivar, seed rate, row spacing, and row direction) are under-exploited as weed control methods, and offer considerable potential for achieving environmentally benign weed management. This special issue on “Eco-friendly Weed Management” will address the role of crop competition in managing weeds in different crops as well as in different countries

Carrier-induced epitope-specific regulation and its bypass in a protein-protein conjugate

In the course of clinical trials on a birth control vaccine, it was found that some of the immunized women responded poorly to booster immunizations. This vaccine consists of a dimer of theβ chain of human chorionic gonadotropin (βhCG) and the α chain of ovine luteinizing hormone (αoLH), linked to tetanus toxoid (TT) as a carrier. Changing this carrier to diphtheria toxoid resulted in reversion to high anti-hCG antibody titers, indicating the extent to which the carrier influences anti-ligand responses in this system. The suppression of anti-hCG responses after booster immunizations was reminiscent of the phenomenon of carrier-induced, epitope-specific regulation. In a mouse model designed to test the effects of preimmunization with TT on anti-hCG responses, we found that a single preimmunization with TT causes reduced anti-αhCG antibody responses in two out of four mouse strains, while anti-αoLH antibody responses were not affected by the preimmunization with TT. This is particularly interesting considering that β hCG and αoLH were not presented when linked separately to TT. In an effort to devise a strategy to circumvent this carrier-induced, ligand-specific hyporesponsiveness, we investigated the effectiveness of a synthetic T helper epitope from TT as carrier. We show that preimmunization with TT causes a less profound reduction in anti-hCG titers if the preimmunized mice are subsequently injected with αoLH-β hCG conjugated to a synthetic tetanus toxin peptide recognized by TT-induced and peptide-induced T cells

Relations of rice seeding rates to crop and weed growth in aerobic rice

Aerobic rice describes a management adaptation to reduced irrigation water supplies but, due to reduced intervals of flooding in this system, this requires revised weed management approaches to reduce costs and provide effective weed control. One approach is to make the crop more competitive and reduce the effects of weeds on the crop by using higher rice seeding rates. A study was conducted in the Philippines and India in 2008 and 2009 to assess the relations of seeding rates (15-125kgha-1) of hybrid and inbred varieties to crop and weed growth in aerobic rice. Plant densities, tillers, and biomass of rice increased linearly with increased in seeding rates under both weedy and weed free environments. Weed biomass decreased linearly with increasing seeding rates from 15 to 125kgha-1. Panicles and grain yields of rice in competition with weeds increased in a quadratic relation with increased seeding rates at both locations; however, the response was flat in the weed free plots. A quadratic model predicted that seeding rates of 48-80kgha-1 for the inbred varieties and 47-67kgha-1 for the hybrid varieties were needed to achieve maximum grain yield when grown in the absence of weeds, while rates of 95-125kgseedha-1 for the inbred varieties and 83-92kg seed ha-1 for the hybrid varieties were needed to achieve maximum yields in competition with weeds. On the basis of these results, seeding rates greater than 80kgha-1 are advisable where there are risks of severe weed competition. Such high seeding rates may be prohibitive when using expensive seed, and maximum yields are not the only consideration for developing recommendations for optimizing economic returns for farmers. Results of the present study do suggest however that increasing seeding rates of aerobic rice does suppress weed growth and reduce grain yield losses from weed competition. This information could be incorporated in integrated crop management packages to manage weeds more effectively

Synthetic peptides corresponding to a repetitive sequence of malarial histidine rich protein bind haem and inhibit haemozoin formation in vitro

Synthetic peptides containing a repetitive hexapeptide sequence (Ala-His-His-Ala-Ala-Asp) of malarial histidine-rich protein II were evaluated for binding with haem in vitro. The pattern of haem binding suggested that each repeat unit of this sequence provides one binding site for haem. Chloroquine inhibited the haem-peptide complex formation with preferential formation of a haem chloroquine complex. In vitro studies on haem polymerisation showed that none of the peptides could initiate haemozoin formation. However, they could inhibit haemozoin formation promoted by a malarial parasite extract, possibly by competitively binding free haem. These results indicate this hexapeptide sequence represents the haem binding site of the malarial histidine-rich protein and possibly the site of nucleation for haem polymerisation

Crop Establishment and Weed Control Options for Sustaining Dry Direct Seeded Rice Production in Eastern India

Dry direct seeded rice (DSR) has emerged as an economically viable alternative to puddled transplanted rice to address emerging constraints of labor and water scarcity and the rising cost of cultivation. However, wide adoption of DSR is seriously constrained by weed management trade-off. Therefore, the availability of effective weed control options is critical for the success and wide-scale adoption of DSR. A field study was conducted at ICAR-National Rice Research Institute, Cuttack, India, in the dry seasons of 2015 and 2016 to evaluate the performance of three crop establishment methods and five weed control practices on weed management, productivity, profitability and energetics of dry DSR. The results demonstrated that weed density and weed dry weight was lower in drill seeding than broadcast seeding by 26–36% and manual line-seeding by 16–24%, respectively, at 30 and 60 days after crop emergence (DAE). Among herbicides, post-emergence application (17 DAE) of azimsulfuron was most effective in controlling weeds compared to early post application of bispyribac-sodium and bensulfuron-methyl+pretilachlor. Weed competition in the weedy check treatment resulted 58% reduction in rice yield. Among establishment methods, drill-seeding was most profitable with US $685 ha−1 higher net income than broadcast seeding primarily due to higher yield. Among weed control treatments, azimsulfuron was most profitable resulting in US$ 160 and 736 ha−1 higher net income than weed free and weedy check, respectively. The specific energy was lowest for drill seeding among establishment method and azimsulfuron among weed control practices, suggesting lowest energy consumed in producing per unit of grain yield

Effect of herbicides on weed management in dry-seeded rice sown under different tillage systems

In India, dry-seeded rice (DSR) production systems are rapidly replacing conventional rice production systems due to various advantages. DSR systems can be managed under zero-till (ZT) conditions or after a preparatory tillage, often referred to as conventional tillage systems (CONT). Although previous reports indicate the contribution of tillage to weed suppression, the effect of one-time preparatory tillage in a DSR system could vary depending on the dominant weeds in the system, vertical seed distribution and the weed seed dynamics. A study was conducted to test the efficacy of ZT and CONT and their interaction with herbicide treatments on the weed population dynamics and rice grain yield in 2010 and 2011. Tillage systems did not affect weed emergence, weed biomass, tiller production and crop yield. However, herbicide treatments varied in their efficacy on individual weeds. Hand-weeding treatments and pendimethalin combined with hand weeding did not effectively control Cyperus rotundus L. and Panicum maximum Jacq. (a perennial grass weed with underground parts). The herbicide combination of metsulfuron and chlorimuron was effective in controlling C. rotundus but not grass weeds. This indicates the need for sequential applications of herbicides for grass weed control or integration of hand weeding to achieve broad-spectrum weed control. Apart from hand weeding (three times), treatment with penoxsulam–cyhalofop and pendimethalin followed by (fb) hand weeding resulted in low weed density, high tiller production and grain yield. The study clearly indicates that tillage does not always lead to weed suppression compared with ZT, and herbicides must be chosen based on the dominant weeds in a system. The results of this study are pertinent as herbicide-resistant weeds are rapidly evolving under continuous herbicide selection pressure, which warrants studies on enhancing productivity through low-input, environmentally friendly and sustainable production technology