Naked Dinner: A Comparison of Dionysian and Apollonian Values Between the Beat Generation and Generation Z

Beyond popularized sororities and toga days, ‘Greek life’ has taken on a more ideological meaning when considering the impacts of the Dionysian and Apollonian spirits on Generation Z in comparison to past generations, namely the Beat Generation. The rambunctious Beat Generation characterized by efforts in free love and sexuality, opposition to capitalism and exploration of communism, socialization of drugs, and racial disparity defined the American 1950s. Notorious writers Allen Ginsberg and Jack Kerouac were only some of the representative figures of the Beat Generation but hold great significance when compared to Generation Z which has shared the Beat Generation’s fervor for the Dionysian spirit - or a sense of nonconformity and chaos among a generally uniform or Apollonian society. As consistent with their representative Greek gods, each of the spirits has contributed much to social change movements in both generations but has maintained balance for the preservation of society. In this paper, I compare the dynamic between Dionysian and Apollonian spirits within the Beat Generation and Generation Z. I remark upon the use of technology in the late 2010s to stimulate the Dionysian spirit within Generation Z as well as the literary attempts of Beat Generation writers to push back against Apollonian society in the 1950s. I ultimately argue that while there are many similarities between the Beat Generation and Generation Z in combatting social conformity, the lack of intentionality behind the Beat Generation social movements establishes their concession of the Dionysian spirit as more authentic although Generation Z’s attempts at leveraging the Dionysian spirit to accomplish change have been more successful

Fibro-osseous lesions of the jaws: An insight

Fibro-osseous lesions of the jaws comprise a diverse group of conditions, which are characterized by replacement of normal bone by fibroblasts, collagen fibers, and mineralized tissue. The diagnosis based on microscopy alone is often impossible due to overlapping of histopathologic features. Adequate clinical and para clinical observations, such as patient’s age, sex, location of the lesion, duration of symptoms, imaging characteristics, and histologic findings are necessary to arrive at an accurate diagnosis.Certain cases present features that may be atypical and do not favor a definite diagnosis. Sound knowledge of various fi bro-osseous lesions of craniofacial structures is critical for proper interpretation and diagnosis of these lesions. Despite striking similarity in the clinical, radiographic and to some extent the histologic patterns, the biologic behavior varies; so each lesion may require a diff erent treatment approach. In this review, the most important and frequent features of the fi bro-osseous lesions of jaws along with diff erent classifications are discussed

Formulation and Evaluation of Floating Tablet of Tropisetron

he purpose of this research was to develop a novel gastroretentive drug delivery system based on controlled delivery of active agent. Tropisetron is an indole derivative having the antiemetic activity. It’s a selective serotonin receptor antagonist. Tropisetron blocks the action of serotonin at 5HT3 receptors. It also results in suppression of chemotherapy-and radiotherapy-induced nausea and vomiting. The incorporation of swellable and natural polymer for binding action and also good water solublility with high molecular  weight such as carbopol present it in the gastro retentive floating tablets, which are designed to provide the desired controlled and complete release of drug for prolonged period of time. Lactose was used as filler. Buoyancy was achieved by adding an effervescent mixture of sodium bicarbonate and anhydrous citric acid. Floating tablets were prepared by direct compression method. All the required evaluation parameters such as hardness, friability, drug content uniformity and swelling index were performed and found within the acceptance limit.  The optimized formulation (F7) exhibited 63.87% drug release in 12 hrs emerged as best formulation based on drug release characteristics. Keywords: Tropisetron, Gastroretentive Drug Delivery System, Floating tablet

Nėščiųjų rizikos veiksnių įtaka naujagimių baigtims

Aim of study. To study the adverse neonatal outcomes in relation to prenatal risk factors among just delivered women in the department of Obstetrics and Gynecology in Kaunas Clinics. Objectives. 1. To describe demographic characteristics of women who gave birth from 2015 to 2016 in Kaunas Clinics. 2. To analyse lifestyle and prenatal risk factors of respondents. 3. To analyse correlation between adverse neonatal outcome, lifestyle and risk factor

Characterization of novel disease-causing mutations in ABCG5 and ABCG8

Cardiovascular disease is the leading cause of death throughout the United States and is particularly high in Kentucky, the Ohio River Valley, and Appalachia. Genetics and lifestyle contribute to the risk of cardiovascular disease. Sitosterolemia is a rare form of familial hypercholesterolemia caused by mutations in ABCG5 and ABCG8 and distinguished by the accumulation of phytosterols in plasma and tissue. ABCG5 and ABCG8 form a sterol pump that opposes sterol absorption in the intestine and promotes cholesterol elimination in the liver. ABCG5 and ABCG8 must form a dimer within the endoplasmic reticulum in order to traffic to the cell surface to pump cholesterol. Whole genome and exome sequencing suggest there are over 2000 likely pathogenic mutants of ABCG5 and ABCG8, but only 60 have been clinically confirmed. In collaboration with the Weill Cornell Medical Center, whole genome sequencing was performed in patients with elevated risk for cardiovascular disease, including hypercholesterolemia. 3 patients were identified with elevated phytosterols and novel variants in either ABCG5 or ABCG8 (ABCG8_G216D, ABCG5_R446Q, and ABCG5_Q392P). However, the impact of those variants on G5/G8 formation and trafficking is unknown. To determine this impact, the variants were generated by long-range PCR site-directed mutagenesis and confirmed by Sanger sequencing. Plasmids encoding native and variant ABCG5 and ABCG8 were co-transfected into human Huh7 hepatocytes and cell lysates analyzed by SDS-PAGE and immunoblot analysis. Maturation of G5G8 was assessed by electrophoretic mobility of ABCG5 ABCG8. Assessment of these mutations demonstrates that these novel, likely pathogenic alleles associated with the clinical presentation of Sitosterolemia do not interfere and may enhance maturation of G5G8. However, two appear to disrupt trafficking of the G5G8 transporter to the cell surface. Further analysis of the structure-function relationships of these mutants reveals the possibility for rescue with small molecule chaperones effective in the treatment of Cystic Fibrosis

Performance of Transmit Aperture Selection to Mitigate Jamming

In this work, we investigate the impact of the transmit aperture selection technique to alleviate the effect of jamming on a free space optical (FSO) communication system. We consider the FSO system to suffer from a jamming signal and Gaussian noise concurrently. The analysis in this paper is conducted on the assumption that all wireless optical links follow the negative exponential distribution with pointing error. A general N×1 FSO system is studied, which allows the transmitter to select a link with the maximum channel gain to transmit the information. We derive a closed-form expression of the bit error rate (BER) of the considered FSO system in the presence of a jammer. We extract the analytical coding gain and diversity order from the asymptotic behavior of the derived BER. We show that the transmit aperture selection allows the FSO system corrupted by a jammer to attain a diversity order of 0.5 N, equal to that of a multiple-input single-output FSO system, while appreciably reducing the power requirements of (N − 1) transmitters. The theoretical analysis is verified by simulations. We also make a quantitative comparison with repetitive coding (RC) and optical space shift keying (OSSK) and show that the transmit aperture selection has a 3 dB advantage over RC; moreover, for a 2×1 system, it provides twice the diversity offered by OSSK. The tenacity of aperture selection is also studied numerically for Gamma-Gamma fading FSO channels

Histopathological analysis of ovarian lesions in a tertiary care centre

Background: The occurrence of functional or benign cysts and tumors are quite common in the ovaries. The present study assessed histopathology of ovarian lesions. Materials & Methods: 96 ovarian masses specimens obtained from gynaecological department were studied. Microsections of 5 microns thickness were taken onto glass slides and stained by standard Hematoxylin and Eosin stains. Slides were studied and classified based on WHO guidelines. Results: Age group 21-30 years comprised of 16, 31-40 years 36, 41-50 years 34 and 51-60 years 10 lesions. There were 46 non- neoplastic lesions, 40 benign neoplastic and 10 malignant neoplastic lesions. Common non- neoplastic lesions were follicular cyst in 20, inclusion cyst in 4, corpus luteum cyst in 12, ectopic pregnancy in 3, twisted cyst in 2, endometriosis in 2 and edema of ovary in 3 cases. Common non- neoplastic lesions comprised of fibroma in 20, fibrothecoma in 5, mucinous cystadenoma in 8, serous cystadenoma in 3, mature cystic teratoma in 2 and serous cystadenofibroma in 2 cases. The difference found to be significant (P< 0.05). Conclusion: Common non- neoplastic lesions were follicular cyst, corpus luteum cyst and common benign neoplastic lesions comprised of fibroma and mucinous cystadenoma. Common malignant neoplastic lesions were granulosa cell tumor and papillary serous cystadenoma

Histopathological assessment of placenta in PIH patients

Background: The occurrence of infection, haemorrhage and hypertensive disorders of pregnancy has great impact on mother and foetal well- being. The present study was conducted to perform histopathological assessment of placenta in PIH patients. Materials & Methods: 74 cases with normal and hypertensive pregnancies were selected and were classified patients into 2 groups of 37 each. Group I comprised of patients with hypertension (>140/90 mm Hg) and group II were normal pregnancy. Parameters recorded were gestational age, mean birth weight, mean placenta weight, mean fetoplacental birth ratio. Morphology of placenta was studied. Results: Maximum patients (19) were seen in age group 20-25 years in group I and 18 in group II. Minimum patients (3) in group I and in group II (3) were present in age group 30-35 years and <20 years respectively. Gestational age 37 weeks was seen in 12 in group I and 11 in group II, 38 weeks in 8 in group I and 7 in group II, 39 weeks in 6 in group I and 9 in group II, 40 weeks in 3 in group I and 2 in group II and 41 weeks in 1 in group I and 1 in group II. The mean birth weight was 2862.4 grams in group I and 2548.5 grams in group II, mean placental weight was 482.4 grams in group I and 476.2 grams in group II and fetoplacental ration found to be 6.52 in group I and 6.10 in group II. The mean Syncitial knots/100 villi was 71.4 in group I and 30.5 in group II, hyalinized villi/ 10 lpf was 6.8 in group I and 1.2 in group II, fibrinoid necrosis/100 villi was 12.5 in group I and 3.1 in group II, calcified areas/ 10 lpf was 2.4 in group I and 0.45 in group II and cytotrophoblastic proliferation/ 100 villi was 16.8 in group I and 3.4 in group II. Conclusion: The occurrence of syncitial knots, hyalinized villi, fibrinoid necrosis, calcified areas and cytotrophoblastic proliferation was more in PIH group than control subject

Epithelioid Hemangioma of Lingual Alveolar Mucosa: An Immunohistochemical Case Report

Epithelioid hemangioma is a rare benign vascular lesion that presents as a nodular lesion in the skin of head and neck region. It is a superficial vascular entity which can either be due to tumor or reactive lesion, but the exact etiology is still unknown. We hereby present a rare case which has been reported with the history of small nodular-like growth on mandibular buccal and lingual area. The excisional biopsy was performed and tissue was submitted for histopathological diagnosis. The immunohistochemistry was performed to check the expression of CD31 marker which proved that origin of epithelioid cells was vascular

Quality of Life of Oral Squamous Cell Carcinoma Patients before and after Primary Treatment

Background: HNSCC (head and neck squamous cell carcinoma) is a serious global health problem, with estimated more than 550,000 new cases and 300,000 deaths annually. More than 90% of these malignancies are oral squamous cell carcinoma (OSCC). Materials and Methods: Patients selected were asked to fill the detailed structured case history proforma and thorough clinical examination, structured, pre-designed, pre-evaluated (UW-QOL) UW Questionnaire version 4 on quality of life (QOL) of oral squamous cell carcinoma patients containing thirteen subjective questionnaires and three global questionnaires. All the patients of OSCC after one month (1 month) of radiation and chemotherapy were assessed for quality of life by questionnaire. Result: Post-treatment QOL assessment of OSCC patients reveals a number of problems such as chewing, swallowing, saliva, lack of activity, and mood disturbances. Preoperative clinical features including tumor site, tumor stage, and extent of mouth opening have a significant impact on post-treatment problems in different ways. Conclusion: The need to balance clinician's need and use of health-related quality of life (HRQOL) data against patient's burden should be considered in the selection process