1 research outputs found
<span style="font-size:16.0pt;line-height:115%; font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language:AR-SA">Effect of ethanol extract of <i>Piper betle </i>Linn leaf on healing of NSAID – induced experimental ulcer - A novel role of free radical scavenging action</span>
311-315Treatment with ethanol extract of
leaf of P.
betle
at
a dose of 150 mg/kg body weight daily for 10 days, after induction of peptic
ulcer by NSAID in albino rats, produced significant healing effect. During
healing process, on treatment with the extractive, antioxidative factor, e.g. superoxide
dismutase and catalase activity, mucus and total gastric tissue sulfhydryl
group were increased. In contrast, oxidised lipid and oxidatively modified
proteins were reduced to near normalcy, within 7 to 10 days, however, change in
the untreated group was not significant. The extract also showed significant in
vitro free radical scavenging action. The results suggest that the
antioxidant or free radical scavenging activity of the plant extract, may be
responsible for its healing action