Federated Benchmarking of Medical Artificial Intelligence With MedPerf

Medical artificial intelligence (AI) has tremendous potential to advance healthcare by supporting and contributing to the evidence-based practice of medicine, personalizing patient treatment, reducing costs, and improving both healthcare provider and patient experience. Unlocking this potential requires systematic, quantitative evaluation of the performance of medical AI models on large-scale, heterogeneous data capturing diverse patient populations. Here, to meet this need, we introduce MedPerf, an open platform for benchmarking AI models in the medical domain. MedPerf focuses on enabling federated evaluation of AI models, by securely distributing them to different facilities, such as healthcare organizations. This process of bringing the model to the data empowers each facility to assess and verify the performance of AI models in an efficient and human-supervised process, while prioritizing privacy. We describe the current challenges healthcare and AI communities face, the need for an open platform, the design philosophy of MedPerf, its current implementation status and real-world deployment, our roadmap and, importantly, the use of MedPerf with multiple international institutions within cloud-based technology and on-premises scenarios. Finally, we welcome new contributions by researchers and organizations to further strengthen MedPerf as an open benchmarking platform

Dosage Forms Mentioned in Kashyapa Samhita – A Review

Kashyapa Samhita is an Ayurvedic treatise having main focus on the health and well-being of children and their pathological manifestations. It describes Mantras (Vedic Hymns), Sutikagarogas (diseases of puerperal period), Dhatri (midwife), Dantodbhava (dentition) etc., which has its sole theme devoted to the vicinity of paediatrics. Different dosage forms or medicaments have been depicted in this ancient wisdom of knowledge especially for paediatric diseases. A wide array of herbs, minerals and metals has been used throughout the text. Total 670 formulations mentioned in the classics were screened and formulated into different dosage forms like Swarasa, Kalka, Kwatha, Hima, Sneha, Avaleha, Arista, Asava, Dhoopana, Anjana etc. Various Upa kalpanas like Yavagu, Ksheera, Kambalika etc. also have been amalgamated sporadically in this Samhita. Most of the formulations for internal administration have been advised to administer along with Ghrita and / or honey. In the current review, an attempt has been made to highlight the uniqueness of such formulations and to bring forward the specialities of such formulations with rational behind using these formulations.Â

Sulfobutylether-β-cyclodextrin: A functional biopolymer for drug delivery applications

Sulfobutylether β-cyclodextrin (SBE-β-CD) is a polyanionic cyclic oligosaccharide that contains glucopyranose units forming a torus ring-like structure. SBE-β-CD is gifted with many favorable properties viz. relatively high solubility (>50 folds compared to β-CD), improved stability, and biocompatibility that praised SBE-β-CD as a smart polymer for drug delivery applications. Commercially, SBE-β-CD is popular by its brand name Captisol®. The present review discusses the structure, properties, and preparation methods of SBE-β-CD-based inclusion complexes (ICs). Furthermore, we discuss here the preparation and applications of SBE-β-CD ICs-based nanoparticulate drug delivery systems, which combines the merits of both, ICs (enhanced solubility) and nanoparticles (NPs, targeted therapy). Patents on and FDA-approved Captisol®-enabled products are tabulated in the benefit of readers. The toxicological aspects and current clinical status of SBE-β-CD or SBE-β-CD-based products are briefly explained in the present review. In our opinion, the present review would be a pathfinder to allow dissemination of information on SBE-β-CD.Fil: Pardeshi, Chandrakantsing V.. No especifíca;Fil: Kothawade, Rucha V.. No especifíca;Fil: Markad, Ashwini R.. No especifíca;Fil: Pardeshi, Sagar R.. St. John Institute of Pharmacy and Research; IndiaFil: Kulkarni, Abhijeet D.. Sandip University; IndiaFil: Chaudhari, Prashant J.. No especifíca;Fil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Dhas, Namdev. No especifíca;Fil: Naik, Jitendra B.. Kavayitri Bahinabai Chaudhari North Maharashtra University; IndiaFil: Surana, Sanjay J.. No especifíca;Fil: García, Mónica Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentin

Abstracts of Scientifica 2022

This book contains the abstracts of the papers presented at Scientifica 2022, Organized by the Sancheti Institute College of Physiotherapy, Pune, Maharashtra, India, held on 12–13 March 2022. This conference helps bring researchers together across the globe on one platform to help benefit the young researchers. There were six invited talks from different fields of Physiotherapy and seven panel discussions including over thirty speakers across the globe which made the conference interesting due to the diversity of topics covered during the conference. Conference Title:  Scientifica 2022Conference Date: 12–13 March 2022Conference Location: Sancheti Institute College of PhysiotherapyConference Organizer: Sancheti Institute College of Physiotherapy, Pune, Maharashtra, Indi