Stability of twin circular tunnels in cohesive-frictional soil using the node-based smoothed finite element method (NS-FEM)

This paper presents an upper bound limit analysis procedure using the node-based smoothed finite element method (NS-FEM) and second order cone programming (SOCP) to evaluate the stability of twin circular tunnels in cohesive-frictional soils subjected to surcharge loading. At first stage, kinematically admissible displacement fields of the tunnel problems are approximated by NS-FEM using triangular elements (NS-FEM-T3). Next, commercial software Mosek is employed to deal with the optimization problems, which are formulated as second order cone. Collapse loads as well as failure mechanisms of plane strain tunnels are obtained directly by solving the optimization problems. For twin circular tunnels, the distance between centers of two parallel tunnels is the major parameter used to determine the stability. In this study, the effects of mechanical soil properties and the ratio of tunnel diameter and the depth to the tunnel stability are investigated. Numerical results are verified with those available to demonstrate the accuracy of the proposed method

Exclusive Hadronic D Decays to eta' and eta

Hadronic decay modes $D^0\to(\bar K^0, \bar K^{*0})\eta,\eta'$ and $(D^+,D_s^+)\to(\pi^+,\rho^+)\eta,\eta'$ are studied in the generalized factorization approach. Form factors for $(D,D_s^+)\to(\eta,\eta')$ transitions are carefully evaluated by taking into account the wave function normalization of the eta and eta'. The predicted branching ratios are generally in agreement with experiment except for $D^0\to\bar K^0\eta', D^+\to\pi^+\eta$ and $D_s^+\to\rho^+\eta'$; the calculated decay rates for the first two decay modes are too small by an order of magnitude. We show that the weak decays $D^0\to K^-\pi^+$ and $D^+\to K^+\bar K^0$ followed by resonance-induced final-state interactions (FSI), which are amenable technically, are able to enhance the branching ratios of $D^0\to\bar K^0\eta'$ and $D^+\to\pi^+\eta$ dramatically without affecting the agreement between theory and experiment for $D^0\to\bar K^0\eta$ and $D^+\to\pi^+\eta'$. We argue that it is difficult to understand the observed large decay rates of $D_s^+\to \rho^+\eta'$ and $\rho^+\eta$ simultaneously; FSI, W-annihilation and the production of excess eta' from gluons are not helpful in this regard. The large discrepancy between the factorization hypothesis and experiment for the ratio of $D_s^+\to\rho^+ \eta'$ and $D_s^+\to\eta' e^+\nu$ remains as an enigma.Comment: 15 pages, 1 figure, to appear in Phys. Rev. D. Form factors for D to eta and eta' transitions are slightly change

Dexamethasone and long-term outcome of tuberculous meningitis in Vietnamese adults and adolescents.

BACKGROUND: Dexamethasone has been shown to reduce mortality in patients with tuberculous meningitis but the long-term outcome of the disease is unknown. METHODS: Vietnamese adults and adolescents with tuberculous meningitis recruited to a randomised, double-blind, placebo-controlled trial of adjunctive dexamethasone were followed-up at five years, to determine the effect of dexamethasone on long-term survival and neurological disability. RESULTS: 545 patients were randomised to receive either dexamethasone (274 patients) or placebo (271 patients). 50 patients (9.2%) were lost to follow-up at five years. In all patients two-year survival, probabilities tended to be higher in the dexamethasone arm (0.63 versus 0.55; p = 0.07) but five-year survival rates were similar (0.54 versus 0.51, p = 0.51) in both groups. In patients with grade 1 TBM, but not with grade 2 or grade 3 TBM, the benefit of dexamethasone treatment tended to persist over time (five-year survival probabilities 0.69 versus 0.55, p = 0.07) but there was no conclusive evidence of treatment effect heterogeneity by TBM grade (p = 0.36). The dexamethasone group had a similar proportion of severely disabled patients among survivors at five years as the placebo group (17/128, 13.2% vs. 17/116, 14.7%) and there was no significant association between dexamethasone treatment and disability status at five years (p = 0.32). CONCLUSIONS: Adjunctive dexamethasone appears to improve the probability of survival in patients with TBM, until at least two years of follow-up. We could not demonstrate a five-year survival benefit of dexamethasone treatment which may be confined to patients with grade 1 TBM. TRIAL REGISTRATION: ClinicalTrials.gov NCT01317654

Measurements of |Vub| and |Vcb| from CLEO

I report results from the CLEO collaboration on semileptonic B decays, highlighting measurements of the Cabibbo-Kobayashi-Maskawa matrix elements |Vub| and |Vcb|. I describe the techniques used to obtain the recent improvements in precision for these measurements, notably the use of the b -> s gamma photon spectrum to constrain non-perturbative hadronic effects in semileptonic B decays.Comment: 13 pages, 5 figures, presented at Beauty 200

Replacement of freshwater small-size fish by formulated feed in snakehead (Channa striata) aquaculture: Experimental and commercial-scale pond trials, with economic analysis

Traditional snakehead culture in Southeast Asia relies on use of small-size (trash) fish as food, an unsustainable practice. Following development of weaning methods and testing of formulated feed (FF) in laboratory experiments, we conducted feeding trials of FF vs. trash fish (TF) in experimental ponds at Can Tho University (CTU), followed by similar trials on commercial farms in two provinces in Vietnam. CTU pond trials consisted of five treatments (in triplicate), in which TF was replaced by FF in increasing percentages: 0 (control), 25, 50, 75, and 100% replacement of TF by FF (i.e., three treatments had mixed TF/FF diets). Although survival was significantly reduced in the 100% replacement treatment, and growth was significantly reduced in the 75% and 100% replacement treatments, the cost per kg of fish produced was 28–35% less in those high-replacement treatments compared to the 0% replacement treatment. On-farm trials were then conducted at two farms in An Giang and Dong Thap provinces for 6 months with snakehead fed TF only or FF only. At both farms, survival (73–80%) was not significantly different, but growth was significantly better on FF diet at both; however, FF-fed fish at the An Giang farm showed significantly higher levels of abnormal development. Overall production was about twice as high at the An Giang farm as at Dong Thap, but significantly greater production by FF-fed fish vs. TF-fed fish was only seen at Dong Thap. Sensory evaluation by a tasting panel found no difference in product quality between FF-fed fish, TF-fed fish, and a commercial sample bought in the market. Economic analysis indicated that profits were higher for FF-fed fish from both farms, although production costs and sales varied greatly, reflecting market differences in the two provinces

Nonresonant Three-body Decays of D and B Mesons

Nonresonant three-body decays of D and B mesons are studied. It is pointed out that if heavy meson chiral perturbation theory (HMChPT) is applied to the heavy-light strong and weak vertices and assumed to be valid over the whole kinematic region, then the predicted decay rates for nonresonant charmless 3-body B decays will be too large and especially B^- --> pi^- K^+ K^- greatly exceeds the current experimental limit. This can be understood as chiral symmetry has been applied there twice beyond its region of validity. If HMChPT is applied only to the strong vertex and the weak transition is accounted for by the form factors, the dominant B^* pole contribution to the tree-dominated direct three-body B decays will become small and the branching ratio will be of order 10^{-6}. The decay modes B^- --> (K^- h^+ h^-)_{NR} and bar{B}^0 --> (bar{K}^0 h^+h^-)_{NR} for h = pi, K are penguin dominated. We apply HMChPT in two different cases to study the direct 3-body D decays and compare the results with experiment. Theoretical uncertainties are discussed.Comment: 24 pages, 2 figures. New experimental results of direct 3-body D decays as Reported at ICHEP2002 are included. To appear in Phys. Re

Multilocus sequence typing of Cryptococcus neoformans var. grubii from Laos in a regional and global context.

Cryptococcosis causes approximately 180 000 deaths each year in patients with human immunodeficiency virus (HIV). Patients with other forms of immunosuppression are also at risk, and disease is increasingly recognized in apparently immunocompetent individuals. Cryptococcus neoformans var. grubii, responsible for the majority of cases, is distributed globally. We used the consensus ISHAM Multilocus sequence typing (MLST) scheme to define the population structure of clinical C. neoformans var. grubii isolates from Laos (n = 81), which we placed into the global context using published MLST data from other countries (total N = 1047), including a reanalysis of 136 Vietnamese isolates previously reported. We observed a phylogeographical relationship in which the Laotian population was similar to its neighbor Thailand, being dominated (83%) by Sequence Types (ST) 4 and 6. This phylogeographical structure changed moving eastwards, with Vietnam's population consisting of an admixture of isolates dominated by the ST4/ST6 (35%) and ST5 (48%) lineages. The ST5 lineage is the predominant ST reported from China and East Asia, where it accounts for >90% of isolates. Analysis of genetic distance (Fst) between different populations of C. neoformans var. grubii supports this intermediate structure of the Vietnamese population. The pathogen and host diversity reported from Vietnam provide the strongest epidemiological evidence of the association between ST5 and HIV-uninfected patients. Regional anthropological genetic distances suggest diversity in the C. neoformans var. grubii population across Southeast Asia is driven by ecological rather than human host factors. Where the ST5 lineage is present, disease in HIV-uninfected patients is to be expected

Dexamethasone and Long-Term Outcome of Tuberculous Meningitis in Vietnamese Adults and Adolescents

BACKGROUND: Dexamethasone has been shown to reduce mortality in patients with tuberculous meningitis but the long-term outcome of the disease is unknown. METHODS: Vietnamese adults and adolescents with tuberculous meningitis recruited to a randomised, double-blind, placebo-controlled trial of adjunctive dexamethasone were followed-up at five years, to determine the effect of dexamethasone on long-term survival and neurological disability. RESULTS: 545 patients were randomised to receive either dexamethasone (274 patients) or placebo (271 patients). 50 patients (9.2%) were lost to follow-up at five years. In all patients two-year survival, probabilities tended to be higher in the dexamethasone arm (0.63 versus 0.55; p = 0.07) but five-year survival rates were similar (0.54 versus 0.51, p = 0.51) in both groups. In patients with grade 1 TBM, but not with grade 2 or grade 3 TBM, the benefit of dexamethasone treatment tended to persist over time (five-year survival probabilities 0.69 versus 0.55, p = 0.07) but there was no conclusive evidence of treatment effect heterogeneity by TBM grade (p = 0.36). The dexamethasone group had a similar proportion of severely disabled patients among survivors at five years as the placebo group (17/128, 13.2% vs. 17/116, 14.7%) and there was no significant association between dexamethasone treatment and disability status at five years (p = 0.32). CONCLUSIONS: Adjunctive dexamethasone appears to improve the probability of survival in patients with TBM, until at least two years of follow-up. We could not demonstrate a five-year survival benefit of dexamethasone treatment which may be confined to patients with grade 1 TBM. TRIAL REGISTRATION: ClinicalTrials.gov NCT01317654

The impact of albendazole treatment on the incidence of viral- and bacterial-induced diarrhea in school children in southern Vietnam: study protocol for a randomized controlled trial

Anthelmintics are one of the more commonly available classes of drugs to treat infections by parasitic helminths (especially nematodes) in the human intestinal tract. As a result of their cost-effectiveness, mass school-based deworming programs are becoming routine practice in developing countries. However, experimental and clinical evidence suggests that anthelmintic treatments may increase susceptibility to other gastrointestinal infections caused by bacteria, viruses, or protozoa. Hypothesizing that anthelmintics may increase diarrheal infections in treated children, we aim to evaluate the impact of anthelmintics on the incidence of diarrheal disease caused by viral and bacterial pathogens in school children in southern Vietnam.This is a randomized, double-blinded, placebo-controlled trial to investigate the effects of albendazole treatment versus placebo on the incidence of viral- and bacterial-induced diarrhea in 350 helminth-infected and 350 helminth-uninfected Vietnamese school children aged 6-15 years. Four hundred milligrams of albendazole, or placebo treatment will be administered once every 3 months for 12 months. At the end of 12 months, all participants will receive albendazole treatment. The primary endpoint of this study is the incidence of diarrheal disease assessed by 12 months of weekly active and passive case surveillance. Secondary endpoints include the prevalence and intensities of helminth, viral, and bacterial infections, alterations in host immunity and the gut microbiota with helminth and pathogen clearance, changes in mean z scores of body weight indices over time, and the number and severity of adverse events.In order to reduce helminth burdens, anthelmintics are being routinely administered to children in developing countries. However, the effects of anthelmintic treatment on susceptibility to other diseases, including diarrheal pathogens, remain unknown. It is important to monitor for unintended consequences of drug treatments in co-infected populations. In this trial, we will examine how anthelmintic treatment impacts host susceptibility to diarrheal infections, with the aim of informing deworming programs of any indirect effects of mass anthelmintic administrations on co-infecting enteric pathogens.ClinicalTrials.gov: NCT02597556 . Registered on 3 November 2015

Risk Factors of Streptococcus suis Infection in Vietnam. A Case-Control Study

Background: Streptococcus suis infection, an emerging zoonosis, is an increasing public health problem across South East Asia and the most common cause of acute bacterial meningitis in adults in Vietnam. Little is known of the risk factors underlying the disease. Methods and Findings: A case-control study with appropriate hospital and matched community controls for each patient was conducted between May 2006 and June 2009. Potential risk factors were assessed using a standardized questionnaire and investigation of throat and rectal S. suis carriage in cases, controls and their pigs, using real-time PCR and culture of swab samples. We recruited 101 cases of S. suis meningitis, 303 hospital controls and 300 community controls. By multivariate analysis, risk factors identified for S. suis infection as compared to either control group included eating "high risk" dishes, including such dishes as undercooked pig blood and pig intestine (OR1 = 2.22; 95% CI = [1.15-4.28] and OR2 = 4.44; 95% CI = [2.15-9.15]), occupations related to pigs (OR1 = 3.84; 95% CI = [1.32-11.11] and OR2 = 5.52; 95% CI = [1.49-20.39]), and exposures to pigs or pork in the presence of skin injuries (OR1 = 7.48; 95% CI = [1.97-28.44] and OR2 = 15.96; 95% CI = [2.97-85.72]). S. suis specific DNA was detected in rectal and throat swabs of 6 patients and was cultured from 2 rectal samples, but was not detected in such samples of 1522 healthy individuals or patients without S. suis infection. Conclusions: This case control study, the largest prospective epidemiological assessment of this disease, has identified the most important risk factors associated with S. suis bacterial meningitis to be eating 'high risk' dishes popular in parts of Asia, occupational exposure to pigs and pig products, and preparation of pork in the presence of skin lesions. These risk factors can be addressed in public health campaigns aimed at preventing S. suis infectio