Ideal E/IMRI vs Real E/IMRI system : Observable signature in LISA

Real extreme/intermediate mass ratio inspiral(E/IMRI) systems are likely to contain large accretion disks which could be as massive as the central supermassive black hole. Therefore, contrary to its ideal model, a real E/IMRI system contains a third important component: the accretion disk. We study the influence of these disks on the emitted GW profile and its detectability through proposed LISA observation. We use a semi-relativistic formalism in the Kerr background (Gair & Glampedakis 2006; Barausse & Rezzolla 2008) for the case of transonic accretion flow which is a potential candidate to describe the accretion flows around AGN. The hydrodynamic drag of the disks modified the motion of the companion as a result the emitted wave changes in amplitude and phase. We found that these changes are detectable through the last few years of observation by LISA (in some cases as small as six months) for EMRIs residing within 3 GPc from the detector and for the accretion rate of the primary black hole of the order of $\dot{M}=1 \dot{M}_{Edd}$. These choices of parameter values are consistent with real systems. The drag effect and hence the detectability of the emitted GW is sensitive to the hydrodynamical model of the disk. Therefore such observations will help one to identify the nature of the accretion flow and verify various paradigms of accretion physics.Comment: 17 pages, 17 figure

Re-imaging Capitalism through Social Entrepreneurship

Abstract: Social Entrepreneurship focuses on activities that make world a better place to live in Social Entrepreneurship addresses various social issues. One such issue is rural development and poverty eradication. One way to achieve this is through self-Help groups. Self –Help group ( SHG) is a unique concept in India Self Help group is a homogenous group of people who have come together with the intention of increasing their income, improve their standard of living and status in society. Self –Help groups is a tool to eradicate poverty and encourage rural development. This study looks into journey of two women from two self-help groups of West Bengal. One SHG is located in rural area and another is in urban area. Self help groups helped them in developing their enterprise. These two micro entrepreneurs in turn provided livelihood to many women in their locality. They have been instrumental in providing other women in their locality with decent income. Self-Help groups not only helped in eradication of poverty but also helped in empowerment of women by providing them with income and social recognition

Women Empowerment Index: Construction of a Tool to Measure Rural Women Empowerment Level in India

Poverty ignites the societal gap between men and women, while economic development narrows it down through its gender promotional activities. There is bidirectional relationship between economic development and empowerment of women. Women empowerment, being dependent on complex sociological and economic issues, needs to be measured in terms of specific parameters like ‘access to resources’, ‘decision making capability’ and ‘ability to take a stand’. This particular study develops an Index based on few sector-specific parameters to measure empowerment level of women engaged in Self Help Groups. Both ‘individual empowerment index’ and ‘group empowerment indices’ have been constructed, where‘financial liberty’, ‘ability to take decisions’, ‘heath condition of the women and ‘ability to stand up against the evils of the society’ have been considered as her empowerment parameters. The index was applied on 300 SHG Group members of rural West Bengal, which provided us an idea about the existing level of rural women empowerment in West Bengal

Women Empowerment Index: Construction of a Tool to Measure Rural Women Empowerment Level in India

Poverty ignites the societal gap between men and women, while economic development narrows it down through its gender promotional activities. There is bidirectional relationship between economic development and empowerment of women. Women empowerment, being dependent on complex sociological and economic issues, needs to be measured in terms of specific parameters like ‘access to resources’, ‘decision making capability’ and ‘ability to take a stand’. This particular study develops an Index based on few sector-specific parameters to measure empowerment level of women engaged in Self Help Groups. Both ‘individual empowerment index’ and ‘group empowerment indices’ have been constructed, where‘financial liberty’, ‘ability to take decisions’, ‘heath condition of the women and ‘ability to stand up against the evils of the society’ have been considered as her empowerment parameters. The index was applied on 300 SHG Group members of rural West Bengal, which provided us an idea about the existing level of rural women empowerment in West Bengal

Bioequivalence study of two formulations containing 400 mg dexibuprofen in healthy Indian subjects

Objective: This study presents the results of two-period, two-treatment crossover investigations on 24 healthy Indian male subjects to assess the bioequivalence of two oral formulations containing 400 mg of dexibuprofen (CAS 51146-56-6). An attempt was also made to study the pharmacokinetics of dexibuprofen in the local population of Indian origin.Method: Both of the formulations were administered orally as a single dose separated by a one-week washout period. The concentration of dexibuprofen in plasma was determined by a validated HPLC method with UV detection using carbamazepine as internal standard. The formulations were compared using the parameters area under the plasma concentration-time curve (AUC0-t), area under the plasma concentration-time curve from zero to infinity (AUC0-∞), peak plasma concentration (Cmax), and time to reach peak plasma concentration (tmax).Results: The results of this investigation indicated that there were no statistically significant differences between the logarithmically transformed AUC0-∞ and Cmax values of the two preparations. The 90 % confidence interval for the ratio of the logarithmically transformed AUC0-t, AUC0-∞ and Cmax were within the bioequivalence limit of 0.8-1.25 and the relative bioavailability of the test formulation was 99.04 % of that of reference formulationjok?.Conclusion: Thus, these findings clearly indicate that the two formulations are bioequivalent in terms of rate and extent of drug absorption. Both preparations were well tolerated with no adverse reactions observed throughout the study

Neuropharmacological properties of Mikania scandens (L.) Willd. (Asteraceae)

Mikania scandens (L.) Willd. (Asteraceae), known as climbing hemp weed in English, is a herbaceous climbing vine grown as a weed throughout the plains of the Indian subcontinent. The present study evaluated some neuropharmacological properties of hydroalcoholic extract of aerial parts from M. scandens (HAMS) in experimental animal models. HAMS (at 250 and 500 mg/kg body weight, i.p.) was evaluated for central antinociceptive activity by tail flick method. Locomotor depressant activity was measured by means of an actophotometer. Skeletal muscle relaxant effect was evaluated by using rotarod apparatus and sedative potentiating property by phenobarbitone-induced sleep potentiation study. The results of the present study revealed significant (P<0.001) and dose-dependent central antinociceptive, locomotor depressant, muscle relaxant, and sedative potentiating effects of HAMS, demonstrating its depressant action on the central nervous system (CNS). From the present study, it can be concluded that the aerial parts of M. scandens possessed prominent depressant action on the CNS, as manifested by the important neuropharmacological properties in mice

Evaluation of anti-inflammatory effects of green tea and black tea: A comparative in vitro study

The present study was conducted to evaluate and compare the anti-inflammatory effects of aqueous extracts of green tea and black tea leaves (Camellia sinensis) against the denaturation of protein in vitro. The test extracts at different concentrations were incubated with egg albumin under controlled experimental conditions and subjected to determination of absorbance to assess the anti-inflammatory property. Diclofenac sodium was used as the reference drug. The present results exhibited a concentration-dependent inhibition of protein (albumin) denaturation by both the tea extracts. From the present findings it can be concluded that both green and black tea leaves possessed a marked anti-inflammatory effect against the denaturation of protein, in vitro. Green tea was found to be more active than black tea, plausibly due to the higher flavonoid contents of green tea

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Abstract: The antidiabetic effect of seeds of Strychnos potatorum Linn. was evaluated in a model of diabetes mellitus using streptozotocin (40 mg/kg b.w., i.p.). Changes in fasting blood sugar were estimated periodically for 12 weeks along with weekly measurement of body weight, food and water intake for 4 weeks. The antidiabetic effects were compared with glipizide as the reference hypoglycemic drug. Strychnos potatorum Linn. (100 mg/kg p.o.) significantly reduced fasting blood sugar, the effects being comparable with glipizide (40 mg/kg, p.o.), an established hypoglycemic drug. It also increased body weight along with decreased food and water intake in streptozotocin-induced diabetic rats. Taken together, Strychnos potatorum Linn. shows promise as an effective hypoglycemic compound worthy of future pharmacological investigations

Evaluation of diabetic polyneuropathy in Type 2 diabetes mellitus by nerve conduction study and association of severity of neuropathy with serum sFasL level

Introduction: Diabetes mellitus (DM), a growing health problem globally, has reached epidemic proportions in India. Recently, Fas-mediated apoptosis has been proposed as a causative factor responsible for neuronal degeneration in diabetic polyneuropathy (DPN), but there are very few studies to show association of serum soluble Fas ligand (sFasL) level with severity of neuropathy. Aim and Objective: The aim of this study was to investigate whether serum sFasL, a transmembrane glycoprotein involved in apoptosis, has any association with severity of peripheral neuropathy in Type 2 DM. Materials and Methods: The study was conducted in Department of Physiology in collaboration with Department of Endocrinology, IPGME&R. sFasL levels in serum were assessed using ELISA method in healthy individuals (n = 16), newly diagnosed diabetic controls (n = 16) without any complications, and in DPN cases (n = 33) with predominant neuropathy only. All subjects underwent both electrodiagnostic procedures and vibration perception threshold (VPT) for quantitative assessment of the severity of neuropathy. Using nerve conduction studies, amplitudes, velocities, and latencies of both sensory and motor nerves were recorded. Results: In DPN patients, concentration of sFasL levels (87.53 ± 3.49) was significantly decreased (P < 0.0001) not only when compared with normal controls (225.30 ± 2.97) but also when compared with diabetic patients without any complication (161 ± 3.63). Moreover, the concentration of sFasL is significantly (P < 0.0001) associated with the severity of neuropathy both by VPT and nerve conduction velocity (NCV). Conclusion: Fas-mediated apoptosis is involved in Type 2 DM and might be associated with the severity of polyneuropathy