Adenosine Production Is Essential for Closing the Critical Period of Cortical Plasticity

Sensory inputs from the external world are represented as highly organized systems in the adult brain for effective adaptation to the environment. At the cortical level, this organization is referred to as cortical maps. The establishment of cortical maps begins with early life experiences during the critical period, a brief period during development of heightened sensitivity to sensory stimuli. During this time, organization of cortical maps is plastic and highly subject to change through passive sensory experience. As an animal matures, the critical period closes and changes to cortical maps occur less freely. The cellular mechanisms of cortical map plasticity in adults remain unknown, and are thought to underlie perceptual learning and memory. Based on work in brain slices, it has previously been suggested that the mechanism of cortical map plasticity in the primary auditory cortex (AI) occurs at thalamocortical (TC) synapses in the form of synaptic plasticity. As the critical period closes, adults develop an adenosine-dependent presynaptic gate that prevents TC synaptic plasticity from occurring. By removing the adenosine gate, synaptic plasticity is able to be induced at mature TC synapses. In the present study, I examined if adenosine-dependent presynaptic gating at TC synapses underlies AI cortical map plasticity in live animals. Through genetic deletion of adenosine machinery at TC synapses, I found that cortical map plasticity at AI in adult mice could be induced through passive tone exposure, which was only thought to work during the auditory critical period

A proportional hazard model for the estimation of ionosphere storm occurrence risk

Severe Ionosphere magnetic storms are feared events for integrity and continuity of navigation systems such as EGNOS, the European SBAS (Satellite-Based Augmentation System) complementing GPS and an accurate modelling of this event probability is necessary. Our aim for the work presented in this paper is to give an estimation of the frequency of such extreme magnetic storms per time unit (year) throughout a solar cycle. Thus, we develop an innovative approach based on a proportional hazard model, inspired by the Cox model, with time dependent covariates. The number of storms during a cycle is supposed to be a non-homogeneous Poisson process. The intensity of this process could be expressed as the product of a baseline risk and a risk factor. Contrary to what is done in the Cox model, the baseline risk is one parameter of interest (and not a nuisance one), it is the intensity to estimate. As in Extreme Value Theory, all the high level events will be used to make estimation and the results will be extrapolated to the extreme level ones. After a precise description of the model, we present the estimation results and a model extension. A prediction for the current solar cycle (24th) is also proposed

The propensity to adopt evidence-based practice among physical therapists

<p>Abstract</p> <p>Background</p> <p>Many authors, as well as the American Physical Therapy Association, advocate that physical therapists adopt practice patterns based on research evidence, known as evidence-based practice (EBP). At the same time, physical therapists should be capable of integrating EBP within the day-to-day practice of physical therapy. The purpose of this study was to determine the extent to which personal characteristics and the characteristics of the social system in the workplace influence the propensity of physical therapists to adopt EBP.</p> <p>Methods</p> <p>The study used a 69 item mailed self-completion questionnaire. The questionnaire had four major sections. The first three sections were each drawn from a different theoretical framework and from different authors' work. The instrument was developed to capture the propensity of physical therapists to adopt EBP, characteristics of the social system in the workplace of physical therapists, personal characteristics of physical therapists, and selected demographic variables of physical therapists. The eligible population consisted of 3,897 physical therapists licensed by the state of Georgia in the United States of America. A random sample of 1320 potential participants was drawn.</p> <p>Results</p> <p>939 questionnaires were returned for a response rate of 73%. 831 of the participants' questionnaires were useable and became the basis for the study. There was a moderate association between desire for learning (<it>r </it>= .36, <it>r</it>²= .13), highest degree held (<it>r </it>= .29, <it>r</it>²= .08), practicality (<it>r </it>= .27, <it>r</it>²= .07) and nonconformity (<it>r </it>= .24, <it>r</it>²= .06) and the propensity to adopt EBP. A negative correlation was found between age, years licensed and percentage of time in direct patient care. The findings demonstrated that the best three variables for predicting the propensity to adopt EBP in physical therapy were: desire for learning, highest degree held, and practicality.</p> <p>Conclusion</p> <p>The study confirms there is no single factor to facilitate research evidence into day-to-day practice. Multiple practice change strategies will be needed to facilitate change in practice.</p