Control of HIV-1 gene expression by SR proteins

Cellular proteins are required for all steps of human immunodeficiency virus type 1 (HIV-1) gene expression including transcription, splicing, 3′-end formation/polyadenylation, nuclear export and translation. SR proteins are a family of cellular RNA-binding proteins that regulate and functionally integrate multiple steps of gene expression. Specific SR proteins are best characterised for regulating HIV-1 RNA splicing by binding specific locations in the viral RNA, though recently they have also been shown to control transcription, 3′-end formation, and translation. Due to their importance in regulating HIV-1 gene expression, SR proteins and their regulatory factors are potential antiviral drug targets.</jats:p

Increasing the CpG dinucleotide abundance in the HIV-1 genomic RNA inhibits viral replication

Additional file 1. Codon modification of nucleotides 22-261 in gag inhibits viral replication in SupT1 cells. SupT1 cells were infected with 10 ng of p24Gag for each indicated virus. The amount of infectious virus present at each time point was measured in TZM-bl cells. This is representative of three independent experiments

Characterisation of the Herpes Simplex virus type 1 genome

PARIS7-Bibliothèque centrale (751132105) / SudocSudocFranceF