The Ursinus Weekly, March 13, 1903

Remembered Glory • A weird impression • YMCA • Alumni notes • Biolog dinner • Society notes • Gym exhibition • Items • Philadelphia letter • Among the colleges • Lebanon Valley alumnihttps://digitalcommons.ursinus.edu/weekly/3078/thumbnail.jp

The Ursinus Weekly, January 14, 1910

Group fair • Field House fund • Special offer • Farewell gathering • Modern language meeting • Soloists decided upon • YMCA • Society notes • Letter to the Editor • Vice-President Omwake honored • Prize essays • YWCA • Localshttps://digitalcommons.ursinus.edu/weekly/3093/thumbnail.jp

1927 Ruby Yearbook

A digitized copy of the 1927 Ruby, the Ursinus College yearbook.https://digitalcommons.ursinus.edu/ruby/1029/thumbnail.jp

1903 Ruby Yearbook

A digitized copy of the 1903 Ruby, the Ursinus College yearbook.https://digitalcommons.ursinus.edu/ruby/1006/thumbnail.jp

The Ursinus Weekly, December 12, 1902

Impressions of the football season • A football player\u27s view • Football spirit • Football review • Blenheim • Defects of football • Financial statement • Clubs reorganize • Societies • YMCAhttps://digitalcommons.ursinus.edu/weekly/3067/thumbnail.jp

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

We identified rare coding variants associated with Alzheimer’s disease (AD) in a 3-stage case-control study of 85,133 subjects. In stage 1, 34,174 samples were genotyped using a whole-exome microarray. In stage 2, we tested associated variants (P<1×10-4) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, an additional 14,997 samples were used to test the most significant stage 2 associations (P<5×10-8) using imputed genotypes. We observed 3 novel genome-wide significant (GWS) AD associated non-synonymous variants; a protective variant in PLCG2 (rs72824905/p.P522R, P=5.38×10-10, OR=0.68, MAFcases=0.0059, MAFcontrols=0.0093), a risk variant in ABI3 (rs616338/p.S209F, P=4.56×10-10, OR=1.43, MAFcases=0.011, MAFcontrols=0.008), and a novel GWS variant in TREM2 (rs143332484/p.R62H, P=1.55×10-14, OR=1.67, MAFcases=0.0143, MAFcontrols=0.0089), a known AD susceptibility gene. These protein-coding changes are in genes highly expressed in microglia and highlight an immune-related protein-protein interaction network enriched for previously identified AD risk genes. These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to AD development